CD200R1

CD200R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BFG, 4BFI
Identifiers
Aliases	CD200R1 , CD200R, HCRTR2, MOX2R, OX2R, CD200 receptor 1
External IDs	OMIM: 607546; MGI: 1889024; HomoloGene: 10957; GeneCards: CD200R1; OMA:CD200R1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q13.2 Start 112,921,205 bp [1] End 112,975,103 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B4 Start 44,586,099 bp [2] End 44,615,341 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle epithelium of nasopharynx nasal epithelium bone marrow cell granulocyte monocyte lymph node appendix spleen gallbladder Top expressed in granulocyte stroma of bone marrow calvaria pharynx right lobe of liver embryo lumbar spinal ganglion dermis blood spleen More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding immunoglobulin receptor activity signaling receptor activity glycosylated region protein binding Cellular component integral component of membrane extracellular region receptor complex membrane external side of plasma membrane plasma membrane cell surface Biological process viral process regulation of immune response signal transduction heterotypic cell-cell adhesion intracellular signal transduction Fc receptor signaling pathway regulation of neuroinflammatory response negative regulation of neuroinflammatory response negative regulation of neuron death negative regulation of macrophage migration negative regulation of T cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 131450 57781 Ensembl ENSG00000163606 ENSMUSG00000022667 UniProt Q8TD46 Q9ES57 RefSeq (mRNA) NM_138806 NM_138939 NM_138940 NM_170780 NM_021325 RefSeq (protein) NP_620161 NP_620385 NP_620386 NP_740750 NP_067300 Location (UCSC) Chr 3: 112.92 – 112.98 Mb Chr 16: 44.59 – 44.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. ^{[5] [6] [7]} CD200R1 is expressed on the surface of myeloid cells ^[8] and CD4+ T cells. ^[9] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons, ^[10] epithelial cells, ^[11] endothelial cells, ^[12] fibroblasts, ^[13] and lymphoid cells. ^[14]

CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha), ^[15] interferons, and inducible nitric oxide synthase (iNOS). ^[16]

Function

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000163606 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022667 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi: 10.1016/S1074-7613(00)00023-6 . PMID   10981966.
6. Dick AD, Broderick C, Forrester JV, Wright GJ (January 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Investigative Ophthalmology & Visual Science. 42 (1): 170–6. PMID   11133863.
7. "Entrez Gene: CD200R1 CD200 receptor 1".
8. Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi: 10.1016/s1074-7613(00)00023-6 . PMID   10981966.
9. Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R (2012). "Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells". PLOS ONE. 7 (4) e35466. Bibcode:2012PLoSO...735466C. doi: 10.1371/journal.pone.0035466 . PMC   3322173 . PMID   22496920.
10. Costello DA, Lyons A, Denieffe S, Browne TC, Cox FF, Lynch MA (October 2011). "Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation". The Journal of Biological Chemistry. 286 (40): 34722–32. doi: 10.1074/jbc.M111.280826 . PMC   3186410 . PMID   21835925.
11. Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL (November 2004). "Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?". The Journal of Investigative Dermatology. 123 (5): 880–7. doi: 10.1111/j.0022-202X.2004.23461.x . PMID   15482475.
12. Ko YC, Chien HF, Jiang-Shieh YF, Chang CY, Pai MH, Huang JP, Chen HM, Wu CH (January 2009). "Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions". Journal of Anatomy. 214 (1): 183–95. doi:10.1111/j.1469-7580.2008.00986.x. PMC   2667927 . PMID   19166481.
13. Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G (April 2017). "CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors". Scientific Reports. 7 46662. Bibcode:2017NatSR...746662I. doi:10.1038/srep46662. PMC   5399371 . PMID   28429795.
14. Gentry M, Bodo J, Durkin L, Hsi ED (February 2017). "Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma". The American Journal of Surgical Pathology. 41 (2): 189–194. doi:10.1097/PAS.0000000000000771. PMID   27879516. S2CID   25206581.
15. Pietilä M, Lehtonen S, Tuovinen E, Lähteenmäki K, Laitinen S, Leskelä HV, Nätynki A, Pesälä J, Nordström K, Lehenkari P (2012). "CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells". PLOS ONE. 7 (2) e31671. Bibcode:2012PLoSO...731671P. doi: 10.1371/journal.pone.0031671 . PMC   3282758 . PMID   22363701.
16. Carter DA, Dick AD (June 2004). "CD200 maintains microglial potential to migrate in adult human retinal explant model". Current Eye Research. 28 (6): 427–36. doi:10.1080/02713680490503778. PMID   15512951. S2CID   20846500.

Further reading

• Matsue H (December 2005). "CD 200-mediated regulation of skin immunity". The Journal of Investigative Dermatology. 125 (6): x–xi. doi: 10.1111/j.0022-202X.2005.23978.x . PMID   16354172.
• Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H (October 2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". Journal of Immunology. 175 (7): 4441–9. doi: 10.4049/jimmunol.175.7.4441 . PMID   16177086.
• Cherwinski HM, Murphy CA, Joyce BL, Bigler ME, Song YS, Zurawski SM, Moshrefi MM, Gorman DM, Miller KL, Zhang S, Sedgwick JD, Phillips JH (February 2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function". Journal of Immunology. 174 (3): 1348–56. doi: 10.4049/jimmunol.174.3.1348 . PMID   15661892.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN (July 2004). "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor". Journal of Virology. 78 (14): 7667–76. doi:10.1128/JVI.78.14.7667-7676.2004. PMC   434103 . PMID   15220441.
• Karteris E, Chen J, Randeva HS (April 2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system". The Journal of Clinical Endocrinology and Metabolism. 89 (4): 1957–62. doi: 10.1210/jc.2003-031778 . PMID   15070969.
• Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bigler M, Song Y, Jenmalm M, Gorman D, McClanahan T, Liu MR, Brown MH, Sedgwick JD, Phillips JH, Barclay AN (September 2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200". Journal of Immunology. 171 (6): 3034–46. doi: 10.4049/jimmunol.171.6.3034 . PMID   12960329.
• Vieites JM, de la Torre R, Ortega MA, Montero T, Peco JM, Sánchez-Pozo A, Gil A, Suárez A (June 2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13". Gene. 311: 99–104. doi:10.1016/S0378-1119(03)00562-6. PMID   12853143.

External links

• CD200R1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD200R1 genome location and CD200R1 gene details page in the UCSC Genome Browser .
• Human HCRTR2 genome location and HCRTR2 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.