CD3EAP

POLR1G
Identifiers
Aliases	POLR1G , ASE-1, ASE1, CAST, PAF49, CD3e molecule associated protein, RPA34, RNA polymerase I subunit G, CD3EAP
External IDs	OMIM: 107325 MGI: 1917583 HomoloGene: 17107 GeneCards: POLR1G
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.32 Start 45,406,644 bp [1] End 45,410,737 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A3 Start 19,089,939 bp [2] End 19,093,408 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte mucosa of urinary bladder tibialis anterior muscle gastrocnemius muscle endothelial cell prefrontal cortex quadriceps femoris muscle vastus lateralis muscle left ventricle Top expressed in hand internal carotid artery fossa external carotid artery Paneth cell condyle lip morula foot yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity RNA binding Cellular component RNA polymerase I complex RNA polymerase I transcription regulator complex mitochondrion nucleus nucleoplasm chromosome fibrillar center nucleolus cytosol Biological process transcription initiation from RNA polymerase I promoter termination of RNA polymerase I transcription epigenetic maintenance of chromatin in transcription-competent conformation rRNA transcription transcription elongation from RNA polymerase I promoter transmembrane receptor protein tyrosine kinase signaling pathway transcription by RNA polymerase I Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10849 70333 Ensembl ENSG00000117877 ENSMUSG00000047649 UniProt O15446 Q76KJ5 RefSeq (mRNA) NM_012099 NM_001297590 NM_145822 RefSeq (protein) NP_001284519 NP_036231 NP_665821 Location (UCSC) Chr 19: 45.41 – 45.41 Mb Chr 7: 19.09 – 19.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase I subunit RPA34 is an enzyme that in humans is encoded by the CD3EAP gene. ^{[5] [6] [7] [8]}

Interactions

CD3EAP has been shown to interact with T-cell surface glycoprotein CD3 epsilon chain, ^[5] POLR1E ^[7] and POLR1C. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000117877 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047649 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T (Jul 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". J Biol Chem. 274 (26): 18173–80. doi: 10.1074/jbc.274.26.18173 . PMID   10373416.
6. Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB (Mar 1998). "ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes". Chromosoma. 106 (8): 493–502. doi:10.1007/s004120050271. PMID   9426281. S2CID   10684078.
7. Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jun 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol Cell Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC   434256 . PMID   15226435.
8. "Entrez Gene: CD3EAP CD3e molecule, epsilon associated protein".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID   16806233.
• Panov KI, Panova TB, Gadal O, et al. (2006). "RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor". Mol. Cell. Biol. 26 (14): 5436–48. doi:10.1128/MCB.00230-06. PMC   1592716 . PMID   16809778.
• Skjelbred CF, Saebø M, Nexø BA, et al. (2006). "Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study". BMC Cancer. 6: 175. doi:10.1186/1471-2407-6-175. PMC   1533843 . PMID   16817948.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.

External links

• Human CAST genome location and CAST gene details page in the UCSC Genome Browser .
• Human CD3EAP genome location and CD3EAP gene details page in the UCSC Genome Browser .