Cell division cycle 26 is a protein that in humans is encoded by the CDC26 gene. [5]
Cell division cycle 26 is a protein that in humans is encoded by the CDC26 gene. [5]
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008].
Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during the early stage of anaphase. In humans, separin is encoded by the ESPL1 gene.
The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/CCdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.
Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.
F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.
Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene.
Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.
Cell division cycle 23 homolog , also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.
Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.
Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.
Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.
Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.
Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.
Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.
Sister chromatid cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene.
Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.
BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene.
Glutamate Rich Protein 5 is a protein in humans encoded by the ERICH5 gene, also known as Chromosome 8 open reading frame 47 (C8orf47).
CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.