CDC42EP1

CDC42EP1
Identifiers
Aliases	CDC42EP1 , BORG5, CEP1, MSE55, CDC42 effector protein 1
External IDs	OMIM: 606084; MGI: 1929763; HomoloGene: 5128; GeneCards: CDC42EP1; OMA:CDC42EP1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 37,560,480 bp [1] End 37,569,405 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 78,726,824 bp [2] End 78,735,097 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas body of stomach C1 segment minor salivary glands right coronary artery left adrenal cortex left uterine tube right adrenal gland ascending aorta ectocervix Top expressed in epithelium of stomach left lung left lung lobe right lung lacrimal gland pyloric antrum white adipose tissue right lung lobe subcutaneous adipose tissue interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity cadherin binding involved in cell-cell adhesion Cellular component cytoskeleton membrane endomembrane system focal adhesion cytoplasm plasma membrane Biological process positive regulation of pseudopodium assembly positive regulation of actin filament polymerization Rho protein signal transduction regulation of cell shape positive regulation of GTPase activity cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11135 104445 Ensembl ENSG00000128283 ENSMUSG00000049521 UniProt Q00587 Q91W92 RefSeq (mRNA) NM_152243 NM_027219 RefSeq (protein) NP_689449 NP_081495 Location (UCSC) Chr 22: 37.56 – 37.57 Mb Chr 15: 78.73 – 78.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene. ^{[5] [6] [7]}

CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. The encoded protein, which is secreted, is primarily found in bone marrow. Two transcript variants encoding different isoforms have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000128283 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049521 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bahou WF, Campbell AD, Wicha MS (Aug 1992). "cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression". J Biol Chem. 267 (20): 13986–92. doi: 10.1016/S0021-9258(19)49667-1 . PMID   1629197.
6. Burbelo PD, Snow DM, Bahou W, Spiegel S (Sep 1999). "MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts". Proc Natl Acad Sci U S A. 96 (16): 9083–8. Bibcode:1999PNAS...96.9083B. doi: 10.1073/pnas.96.16.9083 . PMC   17736 . PMID   10430899.
7. "Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1".

External links

• Human CDC42EP1 genome location and CDC42EP1 gene details page in the UCSC Genome Browser .

Further reading

• Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a New Family of Cdc42 and TC10 GTPase-Interacting Proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC   84628 . PMID   10490598.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Hirsch DS, Pirone DM, Burbelo PD (2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J. Biol. Chem. 276 (2): 875–83. doi: 10.1074/jbc.M007039200 . PMID   11035016.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang J, Zhu J, Bu X, et al. (2005). "Cdc42 and RhoB Activation Are Required for Mannose Receptor-mediated Phagocytosis by Human Alveolar Macrophages". Mol. Biol. Cell. 16 (2): 824–34. doi:10.1091/mbc.E04-06-0463. PMC   545914 . PMID   15574879.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.