CDC42EP3

CDC42EP3
Identifiers
Aliases	CDC42EP3 , BORG2, CEP3, UB1, CDC42 effector protein 3
External IDs	OMIM: 606133 MGI: 2384718 HomoloGene: 4708 GeneCards: CDC42EP3
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p22.2 Start 37,641,882 bp [1] End 37,738,468 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 E3 Start 79,641,156 bp [2] End 79,662,520 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia monocyte seminal vesicula glomerulus metanephric glomerulus saphenous vein right ventricle myometrium blood smooth muscle tissue Top expressed in spermatocyte condyle vas deferens urinary bladder seminiferous tubule calvaria ascending aorta semi-lunar valve atrioventricular valve aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity cytoskeletal regulatory protein binding protein binding Cellular component cytoplasm cytosol cytoskeleton membrane endomembrane system actin cytoskeleton plasma membrane Biological process positive regulation of pseudopodium assembly positive regulation of actin filament polymerization Rho protein signal transduction signal transduction regulation of cell shape positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10602 260409 Ensembl ENSG00000163171 ENSMUSG00000036533 UniProt Q9UKI2 Q9CQC5 RefSeq (mRNA) NM_001270436 NM_001270437 NM_001270438 NM_006449 NM_001371569 NM_001371570 NM_026514 RefSeq (protein) NP_001257365 NP_001257366 NP_001257367 NP_006440 NP_001358498 NP_001358499 NP_080790 Location (UCSC) Chr 2: 37.64 – 37.74 Mb Chr 17: 79.64 – 79.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene. ^{[5] [6] [7]}

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation. ^[7]

Interactions

CDC42EP3 has been shown to interact with CDC42 ^{[5] [8]} and RHOQ. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000163171 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036533 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Alberts AS, Bouquin N, Johnston LH, Treisman R (May 1998). "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7". J Biol Chem. 273 (15): 8616–22. doi: 10.1074/jbc.273.15.8616 . PMID   9535835.
6. Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi: 10.1074/jbc.M007039200 . PMID   11035016.
7. "Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3".
8. Joberty, G; Perlungher R R; Macara I G (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. ISSN   0270-7306. PMC   84628 . PMID   10490598.

External links

• Human CDC42EP3 genome location and CDC42EP3 gene details page in the UCSC Genome Browser .

Further reading

• Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC   84628 . PMID   10490598.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Joberty G, Perlungher RR, Sheffield PJ, et al. (2001). "Borg proteins control septin organization and are negatively regulated by Cdc42". Nat. Cell Biol. 3 (10): 861–6. doi:10.1038/ncb1001-861. PMID   11584266. S2CID   58805.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.