CDC42EP3

CDC42EP3
Identifiers
Aliases	CDC42EP3 , BORG2, CEP3, UB1, CDC42 effector protein 3
External IDs	OMIM: 606133; MGI: 2384718; HomoloGene: 4708; GeneCards: CDC42EP3; OMA:CDC42EP3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	37,738,468 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	79,662,520 bp
RNA expression pattern
	Top expressed in
	tibia; ; monocyte; ; seminal vesicula; ; myocardium of left ventricle; ; glomerulus; ; metanephric glomerulus; ; saphenous vein; ; right ventricle; ; tail of epididymis; ; myometrium;
	Top expressed in
	spermatocyte; ; condyle; ; tibiofemoral joint; ; tunica media of zone of aorta; ; granulocyte; ; vas deferens; ; urinary bladder; ; seminiferous tubule; ; calvaria; ; ascending aorta;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity ; cytoskeletal regulatory protein binding ; protein binding ;
Cellular component	cytoplasm ; cytosol ; cytoskeleton ; membrane ; endomembrane system ; actin cytoskeleton ; plasma membrane ;
Biological process	positive regulation of pseudopodium assembly ; positive regulation of actin filament polymerization ; Rho protein signal transduction ; signal transduction ; regulation of cell shape ; positive regulation of GTPase activity ;
	Sources:Amigo / QuickGO
Orthologs
	10602
	260409
	ENSG00000163171
	ENSMUSG00000036533
	Q9UKI2
	Q9CQC5
NM_001270436 ; NM_001270437 ; NM_001270438 ; NM_006449 ; NM_001371569 ;
	NM_001371570
	NM_026514
NP_001257365 ; NP_001257366 ; NP_001257367 ; NP_006440 ; NP_001358498 ;
	NP_001358499
	NP_080790
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 15, 2024

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.^[5]^[6]^[7]

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.^[7]

Interactions

CDC42EP3 has been shown to interact with CDC42 ^[5]^[8] and RHOQ.^[8]

Related Research Articles

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.

Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene.

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Rhotekin is a protein that in humans is encoded by the RTKN gene.

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.

Beta-parvin is a protein that in humans is encoded by the PARVB gene.

Ras-related protein Rab-13 is a protein that in humans is encoded by the RAB13 gene.

Rnd2 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND2.

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SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.

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Dishevelled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.

Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene.

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.

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Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163171 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036533 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Alberts AS, Bouquin N, Johnston LH, Treisman R (May 1998). "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7". J Biol Chem. 273 (15): 8616–22. doi: 10.1074/jbc.273.15.8616 . PMID 9535835.
↑ Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi: 10.1074/jbc.M007039200 . PMID 11035016.
1 2 "Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3".
1 2 Joberty, G; Perlungher R R; Macara I G (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. ISSN 0270-7306. PMC 84628 . PMID 10490598.

External links

Human CDC42EP3 genome location and CDC42EP3 gene details page in the UCSC Genome Browser .

Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC 84628 . PMID 10490598.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Joberty G, Perlungher RR, Sheffield PJ, et al. (2001). "Borg proteins control septin organization and are negatively regulated by Cdc42". Nat. Cell Biol. 3 (10): 861–6. doi:10.1038/ncb1001-861. PMID 11584266. S2CID 58805.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID 15815621.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163171 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036533 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9535835-5] 1 2 Alberts AS, Bouquin N, Johnston LH, Treisman R (May 1998). "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7". J Biol Chem. 273 (15): 8616–22. doi: 10.1074/jbc.273.15.8616 . PMID 9535835.

[pmid11035016-6] Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi: 10.1074/jbc.M007039200 . PMID 11035016.

[entrez-7] 1 2 "Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3".

[pmid10490598-8] 1 2 Joberty, G; Perlungher R R; Macara I G (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. ISSN 0270-7306. PMC 84628 . PMID 10490598.

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CDC42EP3

Contents

Interactions

Related Research Articles

References

External links

Further reading