CDCA5

WP:SE

CDCA5
Identifiers
Aliases	CDCA5 , SORORIN, cell division cycle associated 5
External IDs	OMIM: 609374; MGI: 1915099; HomoloGene: 49860; GeneCards: CDCA5; OMA:CDCA5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.1 Start 65,066,300 bp [1] End 65,084,164 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 6,135,013 bp [2] End 6,141,807 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone right testis left testis ganglionic eminence mucosa of transverse colon testicle bone marrow secondary oocyte appendix Top expressed in primary oocyte zygote secondary oocyte primitive streak fetal liver hematopoietic progenitor cell internal carotid artery Paneth cell otic placode somite external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding protein binding protein-containing complex binding Cellular component cytoplasm cytosol cohesin complex chromosome nucleoplasm chromatin chromosome, centromeric region nucleus Biological process mitotic chromosome condensation positive regulation of exit from mitosis regulation of cohesin loading cell division mitotic sister chromatid cohesion double-strand break repair cell cycle mitotic metaphase plate congression mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113130 67849 Ensembl ENSG00000146670 ENSMUSG00000024791 UniProt Q96FF9 Q9CPY3 RefSeq (mRNA) NM_080668 NM_026410 RefSeq (protein) NP_542399 NP_080686 Location (UCSC) Chr 11: 65.07 – 65.08 Mb Chr 19: 6.14 – 6.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sororin is a protein that in humans is encoded by the CDCA5 gene. ^{[5] [6] [7]}

Function

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. ^[8]

Clinical significance

Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000146670 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024791 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID   12188893.
6. Rankin S, Ayad NG, Kirschner MW (Apr 2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol Cell. 18 (2): 185–200. doi: 10.1016/j.molcel.2005.03.017 . PMID   15837422.
7. "Entrez Gene: CDCA5 cell division cycle associated 5".
8. Schmitz J, Watrin E, Lénárt P, Mechtler K, Peters J (Apr 2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Curr Biol. 17 (7): 630–6. Bibcode:2007CBio...17..630S. doi:10.1016/j.cub.2007.02.029. hdl: 21.11116/0000-0002-101C-D . PMID   17349791. S2CID   11988060.
9. Nguyen M, Koinuma J, Ueda K, Ito T, Tsuchiya E, Nakamura Y, Daigo Y (Jul 2010). "Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis". Cancer Res. 70 (13): 5337–47. doi: 10.1158/0008-5472.CAN-09-4372 . PMID   20551060.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Schmitz J, Watrin E, Lénárt P, et al. (2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Curr. Biol. 17 (7): 630–6. Bibcode:2007CBio...17..630S. doi:10.1016/j.cub.2007.02.029. hdl: 21.11116/0000-0002-101C-D . PMID   17349791. S2CID   11988060.
• Díaz-Martínez LA, Giménez-Abián JF, Clarke DJ (2007). "Regulation of centromeric cohesion by sororin independently of the APC/C". Cell Cycle. 6 (6): 714–24. doi: 10.4161/cc.6.6.3935 . PMID   17361102.

External links

• Human CDCA5 genome location and CDCA5 gene details page in the UCSC Genome Browser .