CDCA7

Last updated
CDCA7
Identifiers
Aliases CDCA7 , JPO1, ICF3, cell division cycle associated 7
External IDs OMIM: 609937; MGI: 1914203; HomoloGene: 49970; GeneCards: CDCA7; OMA:CDCA7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031942
NM_145810

NM_025866

RefSeq (protein)

NP_114148
NP_665809

NP_080142

Location (UCSC) Chr 2: 173.35 – 173.37 Mb Chr 2: 72.31 – 72.32 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell division cycle-associated protein 7 is a protein that in humans is encoded by the CDCA7 gene. [5] [6] [7]

Contents

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000144354 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055612 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Prescott JE, Osthus RC, Lee LA, Lewis BC, Shim H, Barrett JF, Guo Q, Hawkins AL, Griffin CA, Dang CV (Dec 2001). "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation". J Biol Chem. 276 (51): 48276–84. doi: 10.1074/jbc.M107357200 . PMID   11598121.
  6. Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID   12188893.
  7. 1 2 "Entrez Gene: CDCA7 cell division cycle associated 7".

Further reading