CDCA7

CDCA7
Identifiers
Aliases	CDCA7 , JPO1, ICF3, cell division cycle associated 7
External IDs	OMIM: 609937 MGI: 1914203 HomoloGene: 49970 GeneCards: CDCA7
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q31.1 Start 173,354,820 bp [1] End 173,368,997 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 C3 Start 72,306,503 bp [2] End 72,317,237 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence thymus rectum duodenum jejunal mucosa pylorus endometrium pancreatic epithelial cell pancreatic ductal cell bone marrow Top expressed in thymus medial ganglionic eminence hand primitive streak abdominal wall somite maxillary prominence corneal stroma otic placode yolk sac More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 83879 66953 Ensembl ENSG00000144354 ENSMUSG00000055612 UniProt Q9BWT1 Q9D0M2 RefSeq (mRNA) NM_031942 NM_145810 NM_025866 RefSeq (protein) NP_114148 NP_665809 NP_080142 Location (UCSC) Chr 2: 173.35 – 173.37 Mb Chr 2: 72.31 – 72.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell division cycle-associated protein 7 is a protein that in humans is encoded by the CDCA7 gene. ^{[5] [6] [7]}

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000144354 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055612 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Prescott JE, Osthus RC, Lee LA, Lewis BC, Shim H, Barrett JF, Guo Q, Hawkins AL, Griffin CA, Dang CV (Dec 2001). "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation". J Biol Chem. 276 (51): 48276–84. doi: 10.1074/jbc.M107357200 . PMID   11598121.
6. Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID   12188893.
7. "Entrez Gene: CDCA7 cell division cycle associated 7".

External links

• Human CDCA7 genome location and CDCA7 gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Osthus RC, Karim B, Prescott JE, et al. (2005). "The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo". Cancer Res. 65 (13): 5620–7. doi:10.1158/0008-5472.CAN-05-0536. PMC   1224734 . PMID   15994934.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Goto Y, Hayashi R, Muramatsu T, et al. (2006). "JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity". Biochim. Biophys. Acta. 1759 (1–2): 60–8. doi:10.1016/j.bbaexp.2006.02.004. PMID   16580749.