CDY1

CDY1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2FBM
Identifiers
Aliases	CDY1 , CDY, CDY1A, chromodomain protein, Y-linked, 1, chromodomain Y-linked 1
External IDs	OMIM: 400016 HomoloGene: 36165 GeneCards: CDY1
Gene location (Human)
Chr.	Y chromosome (human)
End	25,624,902 bp
RNA expression pattern
	Top expressed in
	testicle; ; multicellular organism;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	histone acetyltransferase activity ; methylated histone binding ; transferase activity ; acyltransferase activity ; catalytic activity ; transcription corepressor activity ;
Cellular component	nucleus ;
Biological process	histone acetylation ; metabolism ; spermatogenesis ; negative regulation of nucleic acid-templated transcription ;
	Sources:Amigo / QuickGO
Orthologs
	9085
	n/a
	ENSG00000172288
	n/a
	Q9Y6F8
	n/a
	NM_004680 ; NM_170723
	n/a
	NP_004671 ; NP_733841
	n/a
	Wikidata
View/Edit Human

Last updated January 29, 2023

Testis-specific chromodomain protein Y 1 is a protein that in humans is encoded by the CDY1 gene.^[3]^[4]

This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined.^[4] The gene is thought to be related to high-altitude adaptation in humans.^[5]

Related Research Articles

The family of heterochromatin protein 1 (HP1) consists of highly conserved proteins, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromeres, sequestration of genes to the nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at the single nucleosome level, gene repression by heterochromatization of euchromatin, and DNA repair. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all eukaryotic chromosomes with the notable exception of budding yeast, in which a yeast-specific silencing complex of SIR proteins serve a similar function. Members of the HP1 family are characterized by an N-terminal chromodomain and a C-terminal chromoshadow domain, separated by a hinge region. HP1 is also found at some euchromatic sites, where its binding can correlate with either gene repression or gene activation. HP1 was originally discovered by Tharappel C James and Sarah Elgin in 1986 as a factor in the phenomenon known as position effect variegation in Drosophila melanogaster.

Histone H4 is a protein that in humans is encoded by the HIST4H4 gene.

Testis-specific Y-encoded protein 1 is a protein that in humans is encoded by the TSPY1 gene.

Ubiquitin specific peptidase 9, Y-linked , also known as USP9Y, is an enzyme which in humans is encoded by the USP9Y gene. It is required for sperm production. This enzyme is a member of the peptidase C19 family and is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.

Deleted in azoospermia protein 3 is a protein that in humans is encoded by the DAZ3 gene.

Histone H2A type 2-C is a protein that in humans is encoded by the HIST2H2AC gene.

Non-histone chromosomal protein HMG-17 is a protein that in humans is encoded by the HMGN2 gene.

Deleted in azoospermia protein 2 is a protein that in humans is encoded by the DAZ2 gene.

ATP-dependent RNA helicase DDX3Y is an enzyme that in humans is encoded by the DDX3Y gene.

Spermatid nuclear transition protein 1 is a protein that in humans is encoded by the TNP1 gene.

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.

Structural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is encoded by the SMC4 gene. SMC-4 is a core subunit of condensin I and II, large protein complexes involved in chromosome condensation.

Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene. It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily.

Carboxypeptidase A4 is an enzyme that in humans is encoded by the CPA4 gene.

Variable charge X-linked protein 1 is a protein that in humans is encoded by the VCX gene.

Histone H2A.J is a protein that in humans is encoded by the H2AFJ gene.

Homeobox protein ESX1 is a protein that in humans is encoded by the ESX1 gene.

Serine/threonine-protein kinase haspin is an enzyme that in humans is encoded by the GSG2 gene.

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.

Short-stature homeobox 2, also known as homeobox protein Og12X or paired-related homeobox protein SHOT, is a protein that in humans is encoded by the SHOX2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172288 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
1 2 "Entrez Gene: CDY1 chromodomain protein, Y-linked, 1".
↑ Zhang YB, Li X, Zhang F, Wang DM, Yu J (2012). "A preliminary study of copy number variation in Tibetans". PLOS ONE. 7 (7): e41768. Bibcode:2012PLoSO...741768Z. doi: 10.1371/journal.pone.0041768 . PMC 3402393 . PMID 22844521.

External links

Human CDY1 genome location and CDY1 gene details page in the UCSC Genome Browser .

Jones DO, Cowell IG, Singh PB (2000). "Mammalian chromodomain proteins: their role in genome organisation and expression". BioEssays. 22 (2): 124–37. CiteSeerX 10.1.1.575.6410 . doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. PMID 10655032.
Yen PH (1999). "A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males". Genomics. 54 (1): 5–12. doi:10.1006/geno.1998.5526. PMID 9806824.
Lahn BT, Page DC (1999). "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome". Nat. Genet. 21 (4): 429–33. doi:10.1038/7771. PMID 10192397. S2CID 8345990.
Saut N, Terriou P, Navarro A, et al. (2000). "The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility". Mol. Hum. Reprod. 6 (9): 789–93. doi: 10.1093/molehr/6.9.789 . PMID 10956550.
Kleiman SE, Lagziel A, Yogev L, et al. (2001). "Expression of CDY1 may identify complete spermatogenesis". Fertil. Steril. 75 (1): 166–73. doi: 10.1016/S0015-0282(00)01639-3 . PMID 11163833.
Ferlin A, Moro E, Rossi A, Foresta C (2001). "CDY1 analysis in infertile patients with DAZ deletions". J. Endocrinol. Invest. 24 (2): RC4–6. doi:10.1007/bf03343814. PMID 11263480. S2CID 22500357.
Lahn BT, Tang ZL, Zhou J, et al. (2002). "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8707–12. Bibcode:2002PNAS...99.8707L. doi: 10.1073/pnas.082248899 . PMC 124363 . PMID 12072557.
Kostova E, Röttger S, Schempp W, Gromoll J (2003). "Identification and characterization of the cynomolgus monkey chromodomain gene cynCDY, an orthologue of the human CDY gene family". Mol. Hum. Reprod. 8 (8): 702–9. doi: 10.1093/molehr/8.8.702 . PMID 12149400.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi: 10.1038/nature01722 . PMID 12815422.
Dorus S, Gilbert SL, Forster ML, et al. (2003). "The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence". Hum. Mol. Genet. 12 (14): 1643–50. doi: 10.1093/hmg/ddg185 . PMID 12837688.
Kleiman SE, Yogev L, Hauser R, et al. (2003). "Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis". Hum. Genet. 113 (6): 486–92. doi:10.1007/s00439-003-0990-9. PMID 14569460. S2CID 43221279.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172288 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9381176-3] Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.

[entrez-4] 1 2 "Entrez Gene: CDY1 chromodomain protein, Y-linked, 1".

[5] Zhang YB, Li X, Zhang F, Wang DM, Yu J (2012). "A preliminary study of copy number variation in Tibetans". PLOS ONE. 7 (7): e41768. Bibcode:2012PLoSO...741768Z. doi: 10.1371/journal.pone.0041768 . PMC 3402393 . PMID 22844521.

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CDY1

Contents

Related Research Articles

References

External links

Further reading