High-altitude adaptation in humans

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High-altitude adaptation in humans is an instance of evolutionary modification in certain human populations, including those of Tibet in Asia, the Andes of the Americas, and Ethiopia in Africa, who have acquired the ability to survive at altitudes above 2,500 meters (8,200 ft). [1] This adaptation means irreversible, long-term physiological responses to high-altitude environments, associated with heritable behavioural and genetic changes. While the rest of the human population would suffer serious health consequences at high atlitudes, the indigenous inhabitants of these regions thrive well in the highest parts of the world. These humans have undergone extensive physiological and genetic changes, particularly in the regulatory systems of oxygen respiration and blood circulation, when compared to the general lowland population. [2] [3]

Contents

Around 81.6 million humans (approximately 1.1% of the world's human population) live permanently at altitudes above 2,500 meters (8,200 sf), [4] putting these populations at risk for chronic mountain sickness (CMS). [1] However, the high-altitude populations in South America, East Africa, and South Asia have done so for millennia without apparent complications. [5] This special adaptation is now recognised as an example of natural selection in action. [6] The adaptation of the Tibetans is the fastest known example of human evolution, as it is estimated to have occurred around 1,000 BCE. [7] [8] [9] to 7,000 BCE. [10] [11]

Origin and basis

Himalayas, on the southern rim of the Tibetan Plateau Himalayas-Lhasa15.JPG
Himalayas, on the southern rim of the Tibetan Plateau

Humans are naturally adapted to lowland environments where oxygen is abundant. [12] At altitudes above 2,500 meters (8,200 ft), humans experience altitude sickness, which is a type of hypoxia, a clinical syndrome of severe lack of oxygen. Some humans develop the illness beginning at beginning above 1,500 meters (5,000 ft). [13] Symptoms include fatigue, dizziness, breathlessness, headaches, insomnia, malaise, nausea, vomiting, body pain, loss of appetite, ear-ringing, blistering and purpling of the hands and feet, and dilated blood vessels. [14] [15] [16]

The sickness is compounded by related symptoms such as cerebral oedema (swelling of brain) and pulmonary oedema (fluid accumulation in lungs) . [17] [18] Over a span of multiple days, individuals experiencing the effects of high-altitude hypoxia demonstrate raised respiratory activity and elevated metabolic conditions which persist during periods of rest. Subsequently, afflicted people will experience slowly declining heart rate. Hypoxia is a primary contributor to fatalities within mountaineering groups, making it a significant risk factor within high-altitude related challenges. [19] [20] In women, pregnancy can be severely affected, such as development of high blood pressure, called preeclampsia, which causes premature labor, low birth weight of babies, and often complicated with profuse bleeding, seizures, or death of the mother. [2] [21]

An estimated 81.6 million humans live at an elevation higher than 2,500 meters (8,200 ft) above sea level, of which 21.7 million reside in Ethiopia, 12.5 million in China, 11.7 million in Colombia, 7.8 million in Peru, and 6.2 million in Bolivia. [4] Certain natives of Tibet, Ethiopia, and the Andes have been living at these high altitudes for generations and are resistant to hypoxia as a consequence of genetic adaptation. [5] [14] It is estimated that at 4,000 meters (13,000 ft), every lungful of air only has 60% of the oxygen molecules that humans at sea level have. [22] Highlanders are thus constantly exposed to a low oxygen environment, yet they live without any debilitating problems. [23] One of the best-documented effects of high altitude is a progressive reduction in birth weight. It has been known that women of the long-resident, high-altitude population are not affected. These women are known to give birth to heavier-weight infants than women of lowland inhabitants. This is particularly true among Tibetan babies, whose average birth weight is 294–650 (~470) g heavier than the surrounding Chinese population; and their blood-oxygen level is considerably higher. [24]

Scientific investigation of high-altitude adaptation was initiated by A. Roberto Frisancho of the University of Michigan in the late 1960s among the Quechua people of Peru. [25] [26] Paul T. Baker, Penn State University, (in the Department of Anthropology) also conducted a considerable amount of research into human adaptation to high altitudes, and mentored students who continued this research. [27] One of these students, anthropologist Cynthia Beall of Case Western Reserve University, began conducting research on high altitude adaptation among the Tibetans in the early 1980s, research which has continued for decades. [28]

Physiological basis

Tibetans

A Sherpa family Sherpa.jpg
A Sherpa family

In the early 20th century, researchers observed the impressive physical abilities of Tibetans during Himalayan climbing expeditions. They considered the possibility that these abilities resulted from an evolutionary genetic adaptation to high-altitude conditions. [29] The Tibetan plateau has an average elevation of 4,000 meters (13,000 ft) above sea level, and covering more than 2.5 million km2, it is the highest and largest plateau in the world. In 1990, it was estimated that 4,594,188 Tibetans live on the plateau, with 53% living at an altitude over 3,500 meters (11,500 ft). Fairly large numbers (approximately 600,000) live at an altitude exceeding 4,500 meters (14,800 ft) in the Chantong-Qingnan area. [30] Where the Tibetan highlanders live, the oxygen level is only about 60% of that at sea level. The Tibetans, who have been living in this region for 3,000 years, do not exhibit the elevated hemoglobin concentrations to cope with oxygen deficiency as observed in other populations who have moved temporarily or permanently at high altitudes. Instead, the Tibetans inhale more air with each breath and breathe more rapidly than either sea-level populations or Andeans. Tibetans have better oxygenation at birth, enlarged lung volumes throughout life, and a higher capacity for exercise. They show a sustained increase in cerebral blood flow, lower hemoglobin concentration, and less susceptibility to chronic mountain sickness than other populations, due to their longer history of high-altitude habitation. [31] [32]

With the proper physical preparation, individuals can develop short-term tolerance. However, these biological changes are temporary and will reverse upon returning to lower elevations. [33] Moreover, while lowland people typically experience increased breathing for only a few days after entering high altitudes, Tibetans maintain this rapid breathing and elevated lung capacity throughout their lifetime [34] This enables them to inhale large amounts of air per unit of time to compensate for low oxygen levels. Additionally, Tibetans typically have significantly higher levels of nitric oxide in their blood, often double that of lowlanders. This likely contributes to enhanced blood circulation by promoting dilate in their blood vessels. [35] Furthermore, their hemoglobin level is not significantly different (average 15.6 g/dl in males and 14.2 g/dl in females), [36] from those of humans living at low altitude. This is evidenced by mountaineers experiencing an increase of over 2 g/dl in hemoglobin levels within two weeks at the Mt. Everest base camp. [37] ) Consequently, Tibetans demonstrate the capacity to mitigate the effects of hypoxia and mountain sickness throughout their lives. Even when ascending extraordinarily high peaks such as Mount Everest, they exhibit consistent oxygen uptake, heightened ventilation, augmented hypoxic ventilatory responses, expanded lung volumes, increased diffusing capacities, stable body weight, and improved sleep quality compared to lowland populations. [38]

Andeans

In contrast to the Tibetans, who have lived at high altitudes for no more than 11,000 years, the Andean highlanders show different patterns of hemoglobin adaptation. Their hemoglobin concentration is higher than those of the lowlander population, which also happens to lowlanders moving to high altitudes. When they spend some weeks in the lowlands, their hemoglobin drops to the average of other humans. This shows only temporary and reversible acclimatization. However, in contrast to lowland people, they have increased oxygen levels in their hemoglobin, that is, more oxygen per blood volume than other humans. This confers an ability to carry more oxygen in each red blood cell, making a more effective transport of oxygen in their body while their breathing is at the same rate. [34] This enables them to overcome hypoxia and normally reproduce without risk of death for the mother or baby. The Andean highlanders are known from the 16th-century missionaries that their reproduction had always been expected, without any effect on the giving birth or the risk for early pregnancy loss, common to hypoxic stress. [39] They have developmentally acquired enlarged residual lung volume and its associated increase in alveolar area, which are supplemented with increased tissue thickness and moderate increase in red blood cells. Though the physical growth in body size is delayed, change in lung volumes is accelerated. [40] An incomplete adaptation such as elevated hemoglobin levels still leaves them at risk for mountain sickness with old age.

Quechua woman with llamas QuechuaWoman.jpg
Quechua woman with llamas

Among the Quechua people of the Altiplano, there is a significant variation in NOS3 (the gene encoding endothelial nitric oxide synthase, eNOS), which is associated with higher levels of nitric oxide in high altitude. [41] Nuñoa children of Quechua ancestry exhibit higher blood-oxygen content (91.3) and lower heart rate (84.8) than their counterpart school children of different ethnicity, who have an average of 89.9 blood-oxygen and 88–91 heart rate. [42] High-altitude born and bred females of Quechua origins have comparatively enlarged lung volume for increased respiration. [43]

Aymara ceremony Aymara ceremony copacabana 4.jpg
Aymara ceremony

Blood profile comparisons show that among the Andeans, Aymaran highlanders are better adapted to highlands than the Quechuas. [44] [45] Among the Bolivian Aymara people, the resting ventilation and hypoxic ventilatory response were quite low (roughly 1.5 times lower), in contrast to those of the Tibetans. The intrapopulation genetic variation was relatively less among the Aymara people. [46] [47] Moreover, when compared to Tibetans, the blood hemoglobin level at high altitudes among Aymaran is notably higher, with an average of 19.2 g/dl for males and 17.8 g/dl for females. [36] Among the different native highlander populations, the underlying physiological responses to adaptation differ. For example, among four quantitative features, such as resting ventilation, hypoxic ventilatory response, oxygen saturation, and hemoglobin concentration, the levels of variations are significantly different between the Tibetans and the Aymaras. [48] Methylation also influences oxygenation. [49]

Ethiopians

The humans of the Ethiopian highlands also live at extremely high altitudes, around 3,000 meters (9,800 ft) to 3,500 meters (11,500 ft). Highland Ethiopians exhibit elevated hemoglobin levels, like Andeans and lowlander humans at high altitudes, but do not exhibit the Andeans’ increase in oxygen content of hemoglobin. [50] Among healthy individuals, the average hemoglobin concentrations are 15.9 and 15.0 g/dl for males and females, respectively (which is lower than normal, almost similar to the Tibetans), and an average oxygen saturation of hemoglobin is 95.3% (which is higher than average, like the Andeans). [51] Additionally, Ethiopian highlanders do not exhibit any significant change in blood circulation of the brain, which has been observed among the Peruvian highlanders (and attributed to their frequent altitude-related illnesses). [52] Yet, similar to the Andeans and Tibetans, the Ethiopian highlanders are immune to the extreme dangers posed by high-altitude environment, and their pattern of adaptation is definitely unique from that of other highland people. [22]

Genetic basis

The underlying molecular evolution of high-altitude adaptation has been explored and understood fairly recently. [23] Depending on the geographical and environmental pressures, high-altitude adaptation involves different genetic patterns, some of which have evolved quite recently. For example, Tibetan adaptations became prevalent in the past 3,000 years, a rapid example of recent human evolution. At the turn of the 21st century, it was reported that the genetic makeup of the respiratory components of the Tibetan and the Ethiopian populations were significantly different. [48]

Tibetans

Substantial evidence in Tibetan highlanders suggests that variation in hemoglobin and blood-oxygen levels are adaptive as Darwinian fitness. It has been documented that Tibetan women with a high likelihood of possessing one to two alleles for high blood-oxygen content (which is rare in other women) had more surviving children; the higher the oxygen capacity, the lower the infant mortality. [53] In 2010, for the first time, the genes responsible for the unique adaptive traits were identified following genome sequencing of 50 Tibetans and 40 Han Chinese from Beijing. Initially, the strongest signal of natural selection detected was a transcription factor involved in response to hypoxia, called endothelial Per-Arnt-Sim (PAS) domain protein 1 ( EPAS1 ). It was found that one single-nucleotide polymorphism (SNP) at EPAS1 shows a 78% frequency difference between Tibetan and mainland Chinese samples, representing the fastest genetic change observed in any human gene to date. Hence, Tibetan adaptation to high altitude becomes the fastest process of phenotypically observable evolution in humans, [54] which is estimated to have occurred a few thousand years ago, when the Tibetans split up from the mainland Chinese population. The time of genetic divergence has been variously estimated as 2,750 (original estimate), [9] 4,725, [11] 8,000, [55] or 9,000 [10] years ago. Mutations in EPAS1, at higher frequency in Tibetans than their Han neighbors, correlate with decreased hemoglobin concentrations among the Tibetans, which is the hallmark of their adaptation to hypoxia. Simultaneously, two genes, egl nine homolog 1 ( EGLN1 ) (which inhibits hemoglobin production under high oxygen concentration) and peroxisome proliferator-activated receptor alpha ( PPARA ), were also identified to be positively selected about decreased hemoglobin nature in the Tibetans. [56]

Similarly, the Sherpas, known for their Himalayan hardiness, exhibit similar patterns in the EPAS1 gene, which further fortifies that the gene is under selection for adaptation to the high-altitude life of Tibetans. [57] A study in 2014 indicates that the mutant EPAS1 gene could have been inherited from archaic hominins, the Denisovans. [58] EPAS1 and EGLN1 are definitely the major genes for unique adaptive traits when compared with those of the Chinese and Japanese. [59] Comparative genome analysis in 2014 revealed that the Tibetans inherited an equal mixture of genomes from the Nepalese-Sherpas and Hans, and they acquired the adaptive genes from the sherpa-lineage. Further, the population split was estimated to occur around 20,000 to 40,000 years ago, a range of which supports archaeological, mitochondria DNA and Y chromosome evidence for an initial colonization of the Tibetan plateau around 30,000 years ago. [60]

The genes (EPAS1, EGLN1, and PPARA) function in concert with another gene named hypoxia inducible factors (HIF), which in turn is a principal regulator of red blood cell production (erythropoiesis) in response to oxygen metabolism. [61] [62] [63] The genes are associated not only with decreased hemoglobin levels, but also in regulating energy metabolism. EPAS1 is significantly associated with increased lactate concentration (the product of anaerobic glycolysis), and PPARA is correlated with decrease in the activity of fatty acid oxidation. [64] EGLN1 codes for an enzyme, prolyl hydroxylase 2 (PHD2), involved in erythropoiesis. Among the Tibetans, a mutation in EGLN1 (specifically at position 12, where cytosine is replaced with guanine, and at 380, where G is replaced with C) results in mutant PHD2 (aspartic acid at position 4 becomes glutamine, and cysteine at 127 becomes serine) and this mutation inhibits erythropoiesis. The mutation is estimated to occur about 8,000 years ago. [65] Further, the Tibetans are enriched for genes in the disease class of human reproduction (such as genes from the DAZ , BPY2 , CDY , and HLA-DQ and HLA-DR gene clusters) and biological process categories of response to DNA damage stimulus and DNA repair (such as RAD51 , RAD52 , and MRE11A ), which are related to the adaptive traits of high infant birth weight and darker skin tone and are most likely due to recent local adaptation. [66]

Andeans

The patterns of genetic adaptation among the Andeans are largely distinct from those of the Tibetans, with both populations showing evidence of positive natural selection in different genes or gene regions. For genes in the HIF pathway, EGLN1 is the only instance where evidence of positive selection is observed in both Tibetans and Andeans. [67] Even then, the pattern of variation for this gene differs between the two populations. [6] Furthermore, there are no significant associations between EPAS1 or EGLN1 SNP genotypes and hemoglobin concentration among the Andeans, which has been the characteristic of the Tibetans. [68] The Andean pattern of adaptation is characterized by selection in a number of genes involved in cardiovascular development and function (such as BRINP3, EDNRA, NOS2A). [69] [70] This suggests that selection in Andeans, instead of targeting the HIF pathway like in the Tibetans, focused on adaptations of the cardiovascular system to combat chronic disease at high altitude. Analysis of ancient Andean genomes, some dating back 7000 years, discovered selection in DST, a gene involved in cardiovascular function. [71] The whole genome sequences of 20 Andeans (half of them having chronic mountain sickness) revealed that two genes, SENP1 (an erythropoiesis regulator) and ANP32D (an oncogene) play vital roles in their weak adaptation to hypoxia. [72]

Ethiopians

The adaptive mechanism of Ethiopian highlanders is quite different. This is probably because their migration to the highland was relatively early; for example, the Amhara have inhabited altitudes above 2,500 meters (8,200 ft) for at least 5,000 years and lengths around 2,000 meters (6,600 ft) to 2,400 meters (7,900 ft) for more than 70,000 years. [73] Genomic analysis of two ethnic groups, Amhara and Oromo, revealed that gene variations associated with hemoglobin difference among Tibetans or other variants at the exact gene location do not influence the adaptation in Ethiopians. [74] Several candidate genes have been identified as possible explanations for the adaptation of Ethiopians, including CBARA1 , VAV3 , ARNT2 and THRB . Two of these genes (THRB and ARNT2) are known to play a role in the HIF-1 pathway, a pathway implicated in previous work reported in Tibetan and Andean studies. This supports the hypothesis that adaptation to high altitude arose independently among different highlander populations as a result of convergent evolution. [75]

See also

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Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body. Although hypoxia is often a pathological condition, variations in arterial oxygen concentrations can be part of the normal physiology, for example, during strenuous physical exercise.

<span class="mw-page-title-main">Hemoglobin</span> Metalloprotein that binds with oxygen

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<span class="mw-page-title-main">Altitude sickness</span> Medical condition due to rapid exposure to low oxygen at high altitude

Altitude sickness, the mildest form being acute mountain sickness (AMS), is a harmful effect of high altitude, caused by rapid exposure to low amounts of oxygen at high elevation. People can respond to high altitude in different ways. Symptoms may include headaches, vomiting, tiredness, confusion, trouble sleeping, and dizziness. Acute mountain sickness can progress to high-altitude pulmonary edema (HAPE) with associated shortness of breath or high-altitude cerebral edema (HACE) with associated confusion. Chronic mountain sickness may occur after long-term exposure to high altitude.

<span class="mw-page-title-main">Myoglobin</span> Iron and oxygen-binding protein

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Cynthia Beall is an American physical anthropologist at the Case Western Reserve University, Cleveland, Ohio. Four decades of her research on people living in extremely high mountains became the frontier in understanding human evolution and high-altitude adaptation. Her groundbreaking works among the Andean, Tibetan and East African highlanders are the basis of our knowledge on adaptation to hypoxic condition and how it influences the evolutionary selection in modern humans. She is currently the Distinguished University Professor, and member of the U.S. National Academy of Sciences and the American Philosophical Society.

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