DAZ associated protein 1

DAZAP1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2DGS, 2DH8
Identifiers
Aliases	DAZAP1 , DAZ associated protein 1
External IDs	OMIM: 607430 HomoloGene: 137331 GeneCards: DAZAP1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,435,687 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; germinal epithelium; ; spongy bone; ; tibia; ; skin of abdomen; ; sural nerve; ; amniotic fluid; ; parietal pleura; ; vagina; ; right lobe of thyroid gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA stem-loop binding ; nucleic acid binding ; RNA binding ; protein binding ; poly(U) RNA binding ; poly(G) binding ; mRNA 3'-UTR binding ; mRNA binding ;
Cellular component	nucleus ; nucleoplasm ; cytoplasm ; cytosol ; ribonucleoprotein complex ; protein-containing complex ;
Biological process	multicellular organism development ; maternal placenta development ; cell population proliferation ; cell differentiation ; positive regulation of mRNA splicing, via spliceosome ; spermatogenesis ; germ cell development ;
	Sources:Amigo / QuickGO
Orthologs
	26528
	n/a
	ENSG00000071626
	n/a
	Q96EP5
	n/a
	NM_018959 ; NM_170711 ; NM_001352033 ; NM_001352034 ; NM_001352035 Contents Function ; Interactions ; References ; Further reading ;
	n/a
	NP_061832 ; NP_733829 ; NP_001338962 ; NP_001338963 ; NP_001338964
	n/a
	Wikidata
View/Edit Human

Last updated December 11, 2023

DAZ-associated protein 1 is a protein that in humans is encoded by the DAZAP1 gene.^[3]^[4]

Function

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ1 (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.^[4]

Interactions

DAZ associated protein 1 has been shown to interact with DAZ1.^[5]

Related Research Articles

Y linkage, also known as holandric inheritance, describes traits that are produced by genes located on the Y chromosome. It is a form of sex linkage.

Azoospermia factor (AZF) is one of several proteins or their genes, which are coded from the AZF region on the human male Y chromosome. Deletions in this region are associated with inability to produce sperm. Subregions within the AZF region are AZFa, AZFb and AZFc. AZF microdeletions are one of the major causes of male infertility for azoospermia and severe oligozoospermia males. AZF is the term used by the HUGO Gene Nomenclature Committee.

Amelogenin, Y isoform is a protein that in humans is encoded by the AMELY gene. AMELY is located on the Y chromosome and encodes a form of amelogenin. Amelogenin is an extracellular matrix protein involved in biomineralization during tooth enamel development.

Deleted in azoospermia-like is a protein that in humans is encoded by the DAZL gene.

RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2. It is one of 3 proteins in the FET protein family.

Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a protein that in humans is encoded by the HNRNPD gene. Alternative splicing of this gene results in four transcript variants.

Deleted in azoospermia 1, also known as DAZ1, is a protein which in humans is encoded by the DAZ1 gene.

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.

Deleted in azoospermia protein 3 is a protein that in humans is encoded by the DAZ3 gene.

Deleted in azoospermia protein 2 is a protein that in humans is encoded by the DAZ2 gene.

Pumilio homolog 2 is an RNA-binding protein that in humans is encoded by the PUM2 gene.

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.

RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the RBMY1A1 gene.

Testis-specific chromodomain protein Y 1 is a protein that in humans is encoded by the CDY1 gene.

Protein boule-like is a protein that in humans is encoded by the BOLL gene.

DAZ-associated protein 2 is a protein that in humans is encoded by the DAZAP2 gene.

Zinc finger protein DZIP1 is a protein that in humans is encoded by the DZIP1 gene.

Haloacid dehalogenase-like hydrolase domain-containing protein 1A is an enzyme that in humans is encoded by the HDHD1A gene. It encodes a pseudouridine-5'-phosphatase but can also accommodate other phopshorylated metabolites with a lower affinity.

Testis-specific basic protein Y 2 also known as basic charge, Y-linked 2 is a protein that in humans is encoded by the BPY2 gene which resides on the Y chromosome.

The DAZprotein family is a group of three highly conserved RNA-binding proteins that are important in gametogenesis and meiosis. Therefore, mutations in the genes that encode for the DAZ proteins can have detrimental consequences for fertility.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000071626 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (August 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.
1 2 "Entrez Gene: DAZAP1 DAZ associated protein 1".
↑ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

Dai T, Vera Y, Salido EC, Yen PH (2003). "Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL". BMC Genomics. 2: 6. doi: 10.1186/1471-2164-2-6 . PMC 57980 . PMID 11604102.
Vera Y, Dai T, Hikim AP, Lue Y, Salido EC, Swerdloff RS, Yen PH (2003). "Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation". J. Androl. 23 (5): 622–8. doi: 10.1002/j.1939-4640.2002.tb02303.x . PMID 12185095. S2CID 2486961.
Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP (2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia". Leukemia. 19 (5): 806–13. doi:10.1038/sj.leu.2403684. PMID 15744350. S2CID 7228479.
Pan HA, Lin YS, Lee KH, Huang JR, Lin YH, Kuo PL (2006). "Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries". Fertil. Steril. 84 (Suppl 2): 1089–94. doi: 10.1016/j.fertnstert.2005.03.075 . PMID 16209998.
Morton S, Yang HT, Moleleki N, Campbell DG, Cohen P, Rousseau S (2006). "Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ". Biochem. J. 399 (2): 265–73. doi:10.1042/BJ20060681. PMC 1609909 . PMID 16848763.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000071626 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10857750-3] Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (August 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

[entrez-4] 1 2 "Entrez Gene: DAZAP1 DAZ associated protein 1".

[autogenerated1-5] Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

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DAZ associated protein 1

Contents

Function

Interactions

Related Research Articles

References

Further reading