VAV3

VAV3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D86
Identifiers
Aliases	VAV3 , vav guanine nucleotide exchange factor 3
External IDs	OMIM: 605541; MGI: 1888518; HomoloGene: 38143; GeneCards: VAV3; OMA:VAV3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 107,571,161 bp [1] End 107,965,180 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F3 Start 109,247,969 bp [2] End 109,593,014 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla skin of thigh gingival epithelium skin of hip secondary oocyte kidney tubule tibia rectum palpebral conjunctiva hair follicle Top expressed in habenula hair follicle medullary collecting duct medial dorsal nucleus granulocyte medial geniculate nucleus spermatid conjunctival fornix Paneth cell lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding epidermal growth factor receptor binding GTPase activator activity guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol plasma membrane Biological process angiogenesis Fc-gamma receptor signaling pathway involved in phagocytosis intracellular signal transduction ephrin receptor signaling pathway lamellipodium assembly regulation of Rho protein signal transduction positive regulation of phosphatidylinositol 3-kinase activity vascular endothelial growth factor receptor signaling pathway small GTPase mediated signal transduction B cell receptor signaling pathway cell projection assembly Fc-epsilon receptor signaling pathway positive regulation of apoptotic process integrin-mediated signaling pathway cellular response to DNA damage stimulus regulation of cell size regulation of small GTPase mediated signal transduction cell migration platelet activation vesicle fusion positive regulation of cell adhesion positive regulation of B cell proliferation neutrophil chemotaxis regulation of GTPase activity positive regulation of signal transduction positive regulation of GTPase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10451 57257 Ensembl ENSG00000134215 ENSMUSG00000033721 UniProt Q9UKW4 Q9R0C8 RefSeq (mRNA) NM_001079874 NM_006113 NM_020505 NM_146139 NM_001378987 RefSeq (protein) NP_001073343 NP_006104 NP_065251 NP_666251 NP_001365916 Location (UCSC) Chr 1: 107.57 – 107.97 Mb Chr 3: 109.25 – 109.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene. ^[5]

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. ^[5]

Interactions

VAV3 has been shown to interact with Grb2. ^{[6] [7]}

See also

• Actin
• Cytoskeleton
• GTPase

References

1. GRCh38: Ensembl release 89: ENSG00000134215 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033721 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: VAV3 vav 3 oncogene".
6. Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–318. doi:10.1038/nbt790. ISSN   1087-0156. PMID   12577067. S2CID   26838266.
7. Zeng, L; Sachdev P; Yan L; Chan J L; Trenkle T; McClelland M; Welsh J; Wang L H (December 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. ISSN   0270-7306. PMC   102179 . PMID   11094073.

Further reading

• Hobert O, Schilling JW, Beckerle MC, et al. (1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene. 12 (7): 1577–81. PMID   8622875.
• Tamma SM, Chirmule N, Yagura H, et al. (1997). "CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells". Blood. 90 (4): 1588–93. doi: 10.1182/blood.V90.4.1588 . PMID   9269777.
• Trenkle T, Welsh J, Jung B, et al. (1998). "Non-stoichiometric reduced complexity probes for cDNA arrays". Nucleic Acids Res. 26 (17): 3883–3891. doi:10.1093/nar/26.17.3883. PMC   147802 . PMID   9705494.
• Movilla N, Bustelo XR (1999). "Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins". Mol. Cell. Biol. 19 (11): 7870–85. doi:10.1128/mcb.19.11.7870. PMC   84867 . PMID   10523675.
• Trenkle T, McClelland M, Adlkofer K, Welsh J (2000). "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors". Gene. 245 (1): 139–149. doi:10.1016/S0378-1119(00)00026-3. PMID   10713454.
• Zeng L, Sachdev P, Yan L, et al. (2001). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. PMC   102179 . PMID   11094073.
• Inabe K, Ishiai M, Scharenberg AM, et al. (2002). "Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation". J. Exp. Med. 195 (2): 189–200. doi:10.1084/jem.20011571. PMC   2193613 . PMID   11805146.
• Yabana N, Shibuya M (2002). "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity". Oncogene. 21 (50): 7720–7729. doi: 10.1038/sj.onc.1205927 . PMID   12400014.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Zakaria S, Gomez TS, Savoy DN, et al. (2004). "Differential regulation of TCR-mediated gene transcription by Vav family members". J. Exp. Med. 199 (3): 429–434. doi:10.1084/jem.20031228. PMC   2211790 . PMID   14757747.
• Pearce AC, Senis YA, Billadeau DD, et al. (2005). "Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen". J. Biol. Chem. 279 (52): 53955–53962. doi: 10.1074/jbc.M410355200 . PMID   15456756.
• Charvet C, Canonigo AJ, Billadeau DD, Altman A (2005). "Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76". J. Biol. Chem. 280 (15): 15289–15299. doi: 10.1074/jbc.M500275200 . PMID   15708849.
• Lyons LS, Burnstein KL (2006). "Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity". Mol. Endocrinol. 20 (5): 1061–1072. doi: 10.1210/me.2005-0346 . PMID   16384856. S2CID   43049417.
• Dong Z, Liu Y, Lu S, et al. (2006). "Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer". Mol. Endocrinol. 20 (10): 2315–2325. doi: 10.1210/me.2006-0048 . PMID   16762975.