ARNT2

ARNT2
Identifiers
Aliases	ARNT2 , WEDAS, bHLHe1, aryl hydrocarbon receptor nuclear translocator 2
External IDs	OMIM: 606036 MGI: 107188 HomoloGene: 7230 GeneCards: ARNT2
Gene location (Human)
Chr.	Chromosome 15 (human)
End	80,597,933 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	84,059,384 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; middle temporal gyrus; ; frontal pole; ; middle frontal gyrus; ; Brodmann area 10; ; entorhinal cortex; ; optic nerve; ; superior vestibular nucleus; ; parietal lobe; ; ventral tegmental area;
	Top expressed in
	subiculum; ; superior frontal gyrus; ; paraventricular nucleus of hypothalamus; ; globus pallidus; ; nucleus accumbens; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; ganglionic eminence; ; ventral tegmental area; ; lateral hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; protein dimerization activity ; DNA-binding transcription factor activity ; aryl hydrocarbon receptor binding ; DNA-binding transcription activator activity, RNA polymerase II-specific ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; protein binding ; protein heterodimerization activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	cytoplasm ; transcription regulator complex ; nucleus ; nucleoplasm ;
Biological process	response to estradiol ; response to hypoxia ; regulation of transcription, DNA-templated ; negative regulation of apoptotic process ; in utero embryonic development ; transcription by RNA polymerase II ; transcription, DNA-templated ; positive regulation of transcription, DNA-templated ; central nervous system development ; brain development ; positive regulation of cell population proliferation ; xenobiotic metabolic process ; positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	9915
	11864
	ENSG00000172379
	ENSMUSG00000015709
	Q9HBZ2
	Q61324
	NM_014862
	NM_007488
	NP_055677 ; NP_055677.3
	NP_031514
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 26, 2022

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.^[5]^[6]

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.^[6]

Related Research Articles

The aryl hydrocarbon receptor is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought to function primarily as a sensor of xenobiotic chemicals and also as the regulator of enzymes such as cytochrome P450s that metabolize these chemicals. The most notable of these xenobiotic chemicals are aromatic (aryl) hydrocarbons from which the receptor derives its name.

The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.

The aryl-hydrocarbon receptor repressor also known as AHRR is a human gene.

Aryl hydrocarbon receptor nuclear translocator-like 2, also known as Mop9, Bmal2, Clif, or Arntl2, is a gene.

Integral membrane protein GPR155, also known as G protein-coupled receptor 155, is a protein that in humans is encoded by the GPR155 gene. Mutations in this gene may be associated with autism.

Probable G-protein coupled receptor 115 is a protein that in humans is encoded by the GPR115 gene.

Probable G-protein coupled receptor 162 is a protein that in humans is encoded by the GPR162 gene.

Probable G-protein coupled receptor 85 is a protein that in humans is encoded by the GPR85 gene.

Single-minded homolog 2 is a protein that in humans is encoded by the SIM2 gene. It plays a major role in the development of the central nervous system midline as well as the construction of the face and head.

Nuclear receptor coactivator 7 is a protein that in humans is encoded by the NCOA7 gene.

Olfactory receptor 2H2 is a protein that in humans is encoded by the OR2H2 gene.

Olfactory receptor 2B6 is a protein that in humans is encoded by the OR2B6 gene.

Olfactory receptor, family 12, subfamily D, member 2, also known as OR12D2, is a protein which in humans is encoded by the OR12D2 gene.

Olfactory receptor 2J2 is a protein that in humans is encoded by the OR2J2 gene.

Olfactory receptor 2A4 is a protein that in humans is encoded by the OR2A4 gene.

Single-minded homolog 1, also known as class E basic helix-loop-helix protein 14 (bHLHe14), is a protein that in humans is encoded by the SIM1 gene.

Musculin is a protein that in humans is encoded by the MSC gene.

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.

Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) or brain and muscle ARNT-Like 1 (BMAL1) is a protein that in humans is encoded by the ARNTL gene, also known as BMAL1, MOP3, and, less commonly, bHLHe5, BMAL, BMAL1C, JAP3, PASD3, and TIC.

High mobility group nucleosome-binding domain-containing protein 4 is a transcription factor that in humans is encoded by the HMGN4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172379 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015709 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
1 2 "Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2".

External links

Human ARNT2 genome location and ARNT2 gene details page in the UCSC Genome Browser .

Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID 9205841.
Moffett P, Pelletier J (2000). "Different transcriptional properties of mSim-1 and mSim-2". FEBS Lett. 466 (1): 80–6. doi:10.1016/S0014-5793(99)01750-0. PMID 10648817. S2CID 30972686.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Barrow LL, Wines ME, Romitti PA, et al. (2003). "Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts". Teratology. 66 (2): 85–90. doi:10.1002/tera.10062. PMID 12210012.
Stolze I, Berchner-Pfannschmidt U, Freitag P, et al. (2002). "Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells". Blood. 100 (7): 2623–8. doi: 10.1182/blood-2001-12-0169 . PMID 12239177.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ooe N, Saito K, Mikami N, et al. (2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression". Mol. Cell. Biol. 24 (2): 608–16. doi:10.1128/MCB.24.2.608-616.2004. PMC 343817 . PMID 14701734.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Friedman ER, Fan CM (2007). "Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription". Biochem. Biophys. Res. Commun. 363 (1): 113–8. doi:10.1016/j.bbrc.2007.08.108. PMC 2083645 . PMID 17826745.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172379 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015709 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11247670-5] Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.

[entrez-6] 1 2 "Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2".

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ARNT2

Contents

Related Research Articles

References

External links

Further reading