CEACAM7

CEACAM7
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4Y89
Identifiers
Aliases	CEACAM7 , CEA, CGM2, carcinoembryonic antigen related cell adhesion molecule 7, CEA cell adhesion molecule 7
External IDs	HomoloGene: 48476; GeneCards: CEACAM7; OMA:CEACAM7 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.2 Start 41,673,303 bp [1] End 41,706,976 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum mucosa of sigmoid colon mucosa of ileum appendix islet of Langerhans gallbladder testicle palpebral conjunctiva vagina n/a More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 1087 n/a Ensembl ENSG00000280501 ENSG00000007306 n/a UniProt Q14002 n/a RefSeq (mRNA) NM_006890 NM_001291485 n/a RefSeq (protein) NP_001278414 NP_008821 n/a Location (UCSC) Chr 19: 41.67 – 41.71 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Carcinoembryonic antigen-related cell adhesion molecule 7 is a protein that in humans is encoded by the CEACAM7 gene. ^{[3] [4] [5]}

References

1. ENSG00000007306 GRCh38: Ensembl release 89: ENSG00000280501, ENSG00000007306 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Thompson J, Zimmermann W, Nollau P, Neumaier M, Weber-Arden J, Schrewe H, Craig I, Willcocks T (Jan 1995). "CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas". J Biol Chem. 269 (52): 32924–31. doi: 10.1016/S0021-9258(20)30079-X . PMID   7806520.
4. Thompson J, Seitz M, Chastre E, Ditter M, Aldrian C, Gespach C, Zimmermann W (May 1997). "Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis". Cancer Res. 57 (9): 1776–84. PMID   9135022.
5. "Entrez Gene: CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7".

External links

• Human CEACAM7 genome location and CEACAM7 gene details page in the UCSC Genome Browser .

Further reading

• Douard R, Wind P, Sales JP, et al. (2006). "Long-term prognostic value of detection of circulating colorectal cancer cells using CGM2 reverse transcriptase-polymerase chain reaction assay". Surgery. 139 (4): 556–62. doi:10.1016/j.surg.2005.09.025. PMID   16627067.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Schölzel S, Zimmermann W, Schwarzkopf G, et al. (2000). "Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas". Am. J. Pathol. 156 (2): 595–605. doi:10.1016/S0002-9440(10)64764-5. PMC   1850034 . PMID   10666389.
• Frängsmyr L, Baranov V, Hammarström S (1999). "Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat". Tumour Biol. 20 (5): 277–92. doi:10.1159/000030075. PMID   10436421. S2CID   46856322.
• Kinugasa T, Kuroki M, Takeo H, et al. (1998). "Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas". Int. J. Cancer. 76 (1): 148–53. doi: 10.1002/(SICI)1097-0215(19980330)76:1<148::AID-IJC23>3.0.CO;2-7 . PMID   9533775.
• Thompson JA, Mauch EM, Chen FS, et al. (1989). "Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons". Biochem. Biophys. Res. Commun. 158 (3): 996–1004. Bibcode:1989BBRC..158..996T. CiteSeerX   10.1.1.657.2780 . doi:10.1016/0006-291X(89)92821-0. PMID   2537643.
• Khan WN, Frängsmyr L, Teglund S, et al. (1992). "Identification of three new genes and estimation of the size of the carcinoembryonic antigen family". Genomics. 14 (2): 384–90. doi:10.1016/S0888-7543(05)80230-7. PMID   1427854.