CEACAM7

CEACAM7
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4Y89
Identifiers
Aliases	CEACAM7 , CEA, CGM2, carcinoembryonic antigen related cell adhesion molecule 7, CEA cell adhesion molecule 7
External IDs	HomoloGene: 48476 GeneCards: CEACAM7
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,706,976 bp
RNA expression pattern
	Top expressed in
	rectum; ; appendix; ; islet of Langerhans; ; gallbladder; ; palpebral conjunctiva; ; vagina; ; cervix epithelium; ; pancreatic ductal cell; ; epithelium of esophagus; ; cavity of mouth;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Orthologs
	1087
	n/a
	ENSG00000280501 ; ENSG00000007306
	n/a
	Q14002
	n/a
	NM_006890 ; NM_001291485
	n/a
	NP_001278414 ; NP_008821
	n/a
	Wikidata
View/Edit Human

Last updated September 30, 2022

Carcinoembryonic antigen-related cell adhesion molecule 7 is a protein that in humans is encoded by the CEACAM7 gene.^[3]^[4]^[5]

Related Research Articles

Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Consequently, CEA is usually present at very low levels in the blood of healthy adults. However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in clinical tests. Serum levels can also be elevated in heavy smokers.

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) also known as CD66a, is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family.

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) also known as CD66c, is a member of the carcinoembryonic antigen (CEA) gene family..

Pregnancy specific beta-1-glycoprotein 1 (PSBG-1) also known as CD66f, is a protein that in humans is encoded by the PSG1 gene and is a member of the carcinoembryonic antigen (CEA) gene family. Pregnancy-specific glycoproteins (PSGs) are a complex consisting of carbohydrate and protein, which is present in the mammalian body specifically during pregnancy. This glycoprotein is the most abundant protein found in the maternal bloodstream during the later stages of pregnancy and it is of vital importance in fetal development. The PSG functions primarily as an immunomodulator to protect the growing fetus.

Pregnancy-specific beta-1-glycoprotein 9 is a protein that in humans is encoded by the PSG9 gene.

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d, is a member of the carcinoembryonic antigen (CEA) gene family..

CD109 is a human gene.

Pregnancy-specific beta-1-glycoprotein 3 is a protein that in humans is encoded by the PSG3 gene.

Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) also known as CD66b, is a member of the carcinoembryonic antigen (CEA) gene family. Its main function is cell adhesion, cell migration, and pathogen binding.

Pregnancy-specific beta-1-glycoprotein 5 is a protein that in humans is encoded by the PSG5 gene.

Pregnancy-specific beta-1-glycoprotein 4 is a protein that in humans is encoded by the PSG4 gene.

Polymerase delta-interacting protein 2 also known as Polymerase delta-interacting protein of 38 kDa (PDIP38) is encoded by the POLDIP2 gene in humans.

Pregnancy-specific beta-1-glycoprotein 6 is a protein that in humans is encoded by the PSG6 gene.

Galectin-4 is a protein that in humans is encoded by the LGALS4 gene.

Pregnancy-specific beta-1-glycoprotein 10 is a protein that in humans is encoded by the PSG10 gene.

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e, is a member of the carcinoembryonic antigen (CEA) gene family.

Serologically defined colon cancer antigen 8 is a protein that in humans is encoded by the SDCCAG8 gene. This protein localizes to the centrioles.

CD180 antigen is a protein that in humans is encoded by the CD180 gene.

Collectin-12, also known as collectin subfamily member 12, is a collectin protein that in humans is encoded by the COLEC12 gene.

References

1 2 3 ENSG00000007306 GRCh38: Ensembl release 89: ENSG00000280501, ENSG00000007306 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Thompson J, Zimmermann W, Nollau P, Neumaier M, Weber-Arden J, Schrewe H, Craig I, Willcocks T (Jan 1995). "CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas". J Biol Chem. 269 (52): 32924–31. doi: 10.1016/S0021-9258(20)30079-X . PMID 7806520.
↑ Thompson J, Seitz M, Chastre E, Ditter M, Aldrian C, Gespach C, Zimmermann W (May 1997). "Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis". Cancer Res. 57 (9): 1776–84. PMID 9135022.
↑ "Entrez Gene: CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7".

External links

Human CEACAM7 genome location and CEACAM7 gene details page in the UCSC Genome Browser .

Douard R, Wind P, Sales JP, et al. (2006). "Long-term prognostic value of detection of circulating colorectal cancer cells using CGM2 reverse transcriptase-polymerase chain reaction assay". Surgery. 139 (4): 556–62. doi:10.1016/j.surg.2005.09.025. PMID 16627067.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID 15057824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Schölzel S, Zimmermann W, Schwarzkopf G, et al. (2000). "Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas". Am. J. Pathol. 156 (2): 595–605. doi:10.1016/S0002-9440(10)64764-5. PMC 1850034 . PMID 10666389.
Frängsmyr L, Baranov V, Hammarström S (1999). "Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat". Tumour Biol. 20 (5): 277–92. doi:10.1159/000030075. PMID 10436421. S2CID 46856322.
Kinugasa T, Kuroki M, Takeo H, et al. (1998). "Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas". Int. J. Cancer. 76 (1): 148–53. doi: 10.1002/(SICI)1097-0215(19980330)76:1<148::AID-IJC23>3.0.CO;2-7 . PMID 9533775.
Thompson JA, Mauch EM, Chen FS, et al. (1989). "Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons". Biochem. Biophys. Res. Commun. 158 (3): 996–1004. CiteSeerX 10.1.1.657.2780 . doi:10.1016/0006-291X(89)92821-0. PMID 2537643.
Khan WN, Frängsmyr L, Teglund S, et al. (1992). "Identification of three new genes and estimation of the size of the carcinoembryonic antigen family". Genomics. 14 (2): 384–90. doi:10.1016/S0888-7543(05)80230-7. PMID 1427854.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000007306 GRCh38: Ensembl release 89: ENSG00000280501, ENSG00000007306 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7806520-3] Thompson J, Zimmermann W, Nollau P, Neumaier M, Weber-Arden J, Schrewe H, Craig I, Willcocks T (Jan 1995). "CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas". J Biol Chem. 269 (52): 32924–31. doi: 10.1016/S0021-9258(20)30079-X . PMID 7806520.

[pmid9135022-4] Thompson J, Seitz M, Chastre E, Ditter M, Aldrian C, Gespach C, Zimmermann W (May 1997). "Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis". Cancer Res. 57 (9): 1776–84. PMID 9135022.

[entrez-5] "Entrez Gene: CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7".

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CEACAM7

Contents

Related Research Articles

References

External links

Further reading