CENTB1

ACAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JUE, 3T9K, 4CKG, 4CKH, 4F1P, 4NSW
Identifiers
Aliases	ACAP1 , CENTB1, ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
External IDs	OMIM: 607763 MGI: 2388270 HomoloGene: 22835 GeneCards: ACAP1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,351,477 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,786,365 bp
RNA expression pattern
	Top expressed in
	blood; ; lymph node; ; spleen; ; bone marrow cells; ; appendix; ; nucleus accumbens; ; pituitary gland; ; monocyte; ; anterior pituitary; ; sural nerve;
	Top expressed in
	thymus; ; blood; ; lymph node; ; spleen; ; pharynx; ; bone marrow; ; subcutaneous adipose tissue; ; jejunum; ; submandibular gland; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; metal ion binding ; GTPase activator activity ;
Cellular component	endosome ; recycling endosome membrane ; membrane ; intracellular membrane-bounded organelle ;
Biological process	protein transport ; positive regulation of GTPase activity ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	9744
	216859
	ENSG00000072818 ; ENSG00000288169
	ENSMUSG00000001588
	Q15027
	Q8K2H4
	NM_014716
	NM_153788
	NP_055531
	NP_722483
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ACAP1 gene.^[5]^[6]^[7]

Related Research Articles

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References

1 2 3 ENSG00000288169 GRCh38: Ensembl release 89: ENSG00000072818, ENSG00000288169 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001588 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jackson TR, Kearns BG, Theibert AB (Dec 2000). "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling". Trends Biochem Sci. 25 (10): 489–95. doi:10.1016/S0968-0004(00)01644-3. PMID 11050434.
↑ Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151 (3): 627–38. doi:10.1083/jcb.151.3.627. PMC 2185579 . PMID 11062263.
↑ "Entrez Gene: CENTB1 centaurin, beta 1".

External links

Human ACAP1 genome location and ACAP1 gene details page in the UCSC Genome Browser .

Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi: 10.1093/dnares/1.5.223 . PMID 7584044.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Dai J, Li J, Bos E, et al. (2004). "ACAP1 promotes endocytic recycling by recognizing recycling sorting signals". Dev. Cell. 7 (5): 771–6. doi: 10.1016/j.devcel.2004.10.002 . PMID 15525538.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
Yamamoto-Furusho JK, Barnich N, Xavier R, et al. (2007). "Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation". J. Biol. Chem. 281 (47): 36060–70. doi: 10.1074/jbc.M602383200 . PMID 17005562.
Shinozaki-Narikawa N, Kodama T, Shibasaki Y (2007). "Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation". Traffic. 7 (11): 1539–50. doi:10.1111/j.1600-0854.2006.00480.x. PMID 17010122.
Li J, Peters PJ, Bai M, et al. (2007). "An ACAP1-containing clathrin coat complex for endocytic recycling". J. Cell Biol. 178 (3): 453–64. doi:10.1083/jcb.200608033. PMC 2064835 . PMID 17664335.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000288169 GRCh38: Ensembl release 89: ENSG00000072818, ENSG00000288169 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001588 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11050434-5] Jackson TR, Kearns BG, Theibert AB (Dec 2000). "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling". Trends Biochem Sci. 25 (10): 489–95. doi:10.1016/S0968-0004(00)01644-3. PMID 11050434.

[pmid11062263-6] Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151 (3): 627–38. doi:10.1083/jcb.151.3.627. PMC 2185579 . PMID 11062263.

[entrez-7] "Entrez Gene: CENTB1 centaurin, beta 1".

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CENTB1

Contents

Related Research Articles

References

External links

Further reading