CENTB1

ACAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JUE, 3T9K, 4CKG, 4CKH, 4F1P, 4NSW
Identifiers
Aliases	ACAP1 , CENTB1, ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
External IDs	OMIM: 607763; MGI: 2388270; HomoloGene: 22835; GeneCards: ACAP1; OMA:ACAP1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.1 Start 7,336,529 bp [1] End 7,351,477 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B3 Start 69,772,393 bp [2] End 69,786,365 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood lymph node spleen bone marrow cells left testis right testis appendix nucleus accumbens pituitary gland Top expressed in granulocyte thymus blood lymph node mesenteric lymph nodes spleen pharynx bone marrow subcutaneous adipose tissue embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding GTPase activator activity Cellular component endosome recycling endosome membrane membrane intracellular membrane-bounded organelle Biological process protein transport positive regulation of GTPase activity transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9744 216859 Ensembl ENSG00000072818 ENSG00000288169 ENSMUSG00000001588 UniProt Q15027 Q8K2H4 RefSeq (mRNA) NM_014716 NM_153788 RefSeq (protein) NP_055531 NP_722483 Location (UCSC) Chr 17: 7.34 – 7.35 Mb Chr 11: 69.77 – 69.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ACAP1 gene. ^{[5] [6] [7]}

References

1. ENSG00000288169 GRCh38: Ensembl release 89: ENSG00000072818, ENSG00000288169 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001588 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jackson TR, Kearns BG, Theibert AB (Dec 2000). "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling". Trends Biochem Sci. 25 (10): 489–95. doi:10.1016/S0968-0004(00)01644-3. PMID   11050434.
6. Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151 (3): 627–38. doi:10.1083/jcb.151.3.627. PMC   2185579 . PMID   11062263.
7. "Entrez Gene: CENTB1 centaurin, beta 1".

External links

• Human ACAP1 genome location and ACAP1 gene details page in the UCSC Genome Browser .

Further reading

• Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi: 10.1093/dnares/1.5.223 . PMID   7584044.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Dai J, Li J, Bos E, et al. (2004). "ACAP1 promotes endocytic recycling by recognizing recycling sorting signals". Dev. Cell. 7 (5): 771–6. doi: 10.1016/j.devcel.2004.10.002 . PMID   15525538.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID   16777052.
• Yamamoto-Furusho JK, Barnich N, Xavier R, et al. (2007). "Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation". J. Biol. Chem. 281 (47): 36060–70. doi: 10.1074/jbc.M602383200 . PMID   17005562.
• Shinozaki-Narikawa N, Kodama T, Shibasaki Y (2007). "Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation". Traffic. 7 (11): 1539–50. doi:10.1111/j.1600-0854.2006.00480.x. PMID   17010122. S2CID   39282089.
• Li J, Peters PJ, Bai M, et al. (2007). "An ACAP1-containing clathrin coat complex for endocytic recycling". J. Cell Biol. 178 (3): 453–64. doi:10.1083/jcb.200608033. PMC   2064835 . PMID   17664335.