CENTD1

Last updated
ARAP2
Protein CENTD1 PDB 1x40.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARAP2 , CENTD1, PARX, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
External IDs OMIM: 606645; MGI: 2684416; HomoloGene: 9064; GeneCards: ARAP2; OMA:ARAP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015230
NM_139182

NM_178407

RefSeq (protein)

NP_056045

n/a

Location (UCSC) Chr 4: 35.95 – 36.24 Mb Chr 5: 62.76 – 62.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene. [5]

Contents

Function

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. This protein lacks the predicted catalytic arginine in the RHO-GAP domain and is therefore unlikely to have RHO-GAP activity. While the encoded protein does contain a sterile alpha motif (SAM) commonly found in some signaling molecules, the function of the protein has not been determined. Two transcript variants encoding different isoforms have been found for this gene. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000047365 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037999 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: CENTD1 centaurin, delta 1".

Further reading