CENTD3

ARAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KG5, 2LNW, 5JD0, 5JCP
Identifiers
Aliases	ARAP3 , CENTD3, DRAG1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
External IDs	OMIM: 606647 MGI: 2147274 HomoloGene: 11199 GeneCards: ARAP3
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.3 Start 141,653,401 bp [1] End 141,682,230 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B3 Start 38,105,681 bp [2] End 38,132,022 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung blood upper lobe of left lung left ventricle canal of the cervix subcutaneous adipose tissue ganglionic eminence right lobe of thyroid gland right coronary artery left uterine tube Top expressed in yolk sac esophagus lip bone marrow superior frontal gyrus stomach muscle tissue skeletal muscle tissue lung adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding phosphatidylinositol-3,4-bisphosphate binding protein binding GTPase activator activity phosphatidylinositol-3,4,5-trisphosphate binding Cellular component cytosol cell projection membrane plasma membrane cytoskeleton lamellipodium ruffle cytoplasm Biological process positive regulation of GTPase activity negative regulation of Rac protein signal transduction cytoskeleton organization regulation of small GTPase mediated signal transduction vesicle-mediated transport signal transduction negative regulation of cell migration negative regulation of Rho protein signal transduction regulation of cell shape Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64411 106952 Ensembl ENSG00000120318 ENSMUSG00000024451 UniProt Q8WWN8 Q8R5G7 RefSeq (mRNA) NM_022481 NM_001205336 NM_139206 RefSeq (protein) NP_071926 NP_001192265 NP_631945 Location (UCSC) Chr 5: 141.65 – 141.68 Mb Chr 18: 38.11 – 38.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene. ^{[5] [6] [7]}

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000120318 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024451 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, et al. (Jan 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol Cell. 9 (1): 95–108. doi: 10.1016/S1097-2765(02)00434-3 . PMID   11804589.
6. Santy LC, Casanova JE (May 2002). "GTPase signaling: bridging the GAP between ARF and Rho". Curr Biol. 12 (10): R360–2. Bibcode:2002CBio...12.R360S. doi: 10.1016/S0960-9822(02)00860-6 . PMID   12015138. S2CID   15875666.
7. "Entrez Gene: CENTD3 centaurin, delta 3".

External links

• Human ARAP3 genome location and ARAP3 gene details page in the UCSC Genome Browser .

Further reading

• Raaijmakers JH, Deneubourg L, Rehmann H, De Koning J, Zhang Z, Krugmann S, et al. (2007). "The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner". Cell. Signal. 19 (6): 1249–57. doi:10.1016/j.cellsig.2006.12.015. hdl: 1874/35664 . PMID   17314030. S2CID   356352.
• Lu Q, Wei W, Kowalski PE, Chang AC, Cohen SN (2005). "EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin". Proc. Natl. Acad. Sci. U.S.A. 101 (49): 17246–51. doi: 10.1073/pnas.0407794101 . PMC   534609 . PMID   15569923.
• I ST, Nie Z, Stewart A, Najdovska M, Hall NE, He H, et al. (2005). "ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner". J. Cell Sci. 117 (Pt 25): 6071–84. doi: 10.1242/jcs.01526 . PMID   15546919.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Reinhard C, Schweikert M, Wieland FT, Nickel W (2003). "Functional reconstitution of COPI coat assembly and disassembly using chemically defined components". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8253–7. Bibcode:2003PNAS..100.8253R. doi: 10.1073/pnas.1432391100 . PMC   166215 . PMID   12832619.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.