CENTG3

AGAP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IHW
Identifiers
Aliases	AGAP3 , AGAP-3, CENTG3, CRAG, MRIP-1, cnt-g3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
External IDs	OMIM: 616813 MGI: 2183446 HomoloGene: 23742 GeneCards: AGAP3
Gene location (Human)
Chr.	Chromosome 7 (human)
End	151,144,436 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,707,045 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; cingulate gyrus; ; prefrontal cortex; ; amygdala; ; hypothalamus; ; nucleus accumbens; ; anterior pituitary; ; canal of the cervix; ; putamen; ; right lung;
	Top expressed in
	superior frontal gyrus; ; lip; ; cerebellar cortex; ; saccule; ; yolk sac; ; esophagus; ; otic placode; ; neural tube; ; hippocampus proper; ; entorhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; metal ion binding ; GTPase activator activity ; GTPase activity ; polyubiquitin modification-dependent protein binding ;
Cellular component	membrane ; nucleus ; cytoplasm ; cell periphery ;
Biological process	positive regulation of GTPase activity ; signal transduction ; cellular response to reactive oxygen species ; proteasome-mediated ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	116988
	213990
	ENSG00000133612
	ENSMUSG00000023353
	Q96P47 ; Q86ST5
	Q8VHH5
NM_001042535 ; NM_001281300 ; NM_001308304 ; NM_001308305 ; NM_031946 ;
	NM_001350102 ; NM_001350103 ; NM_001350104
	NM_001256431 ; NM_139153 ; NM_001359881
NP_001036000 ; NP_001268229 ; NP_001295233 ; NP_001295234 ; NP_114152 ;
	NP_001337031 ; NP_001337032 ; NP_001337033 ; NP_001036000.1 ; NP_001295233.1 ; NP_001295234.1 Contents References ; External links ; Further reading ;
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 is an enzyme that in humans is encoded by the AGAP3 gene.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133612 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023353 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CENTG3 centaurin, gamma 3".

External links

Human AGAP3 genome location and AGAP3 gene details page in the UCSC Genome Browser .

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Qin Q, Inatome R, Hotta A, et al. (2006). "A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein". J. Cell Biol. 172 (4): 497–504. doi:10.1083/jcb.200505079. PMC 2063670 . PMID 16461359.
Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–49354. doi: 10.1074/jbc.M410565200 . PMID 15381706.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Surks HK, Richards CT, Mendelsohn ME (2004). "Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA". J. Biol. Chem. 278 (51): 51484–51493. doi: 10.1074/jbc.M305622200 . PMID 14506264.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Xia C, Ma W, Stafford LJ, et al. (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Mol. Cell. Biol. 23 (7): 2476–2488. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724 . PMID 12640130.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000133612 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023353 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CENTG3 centaurin, gamma 3".

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CENTG3

Contents

Related Research Articles

References

External links

Further reading