CFHR2

CFHR2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3ZD1, 5EA0
Identifiers
Aliases	CFHR2 , CFHL2, FHR2, HFL3, complement factor H related 2
External IDs	OMIM: 600889; HomoloGene: 130536; GeneCards: CFHR2; OMA:CFHR2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	196,959,622 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; parietal pleura; ; mucosa of paranasal sinus; ; palpebral conjunctiva; ; skin of arm; ; buccal mucosa cell; ; gonad; ; testicle; ; visceral pleura; ; germinal epithelium;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; protein homodimerization activity ; protein heterodimerization activity ;
Cellular component	extracellular region ; protein-containing complex ;
Biological process	regulation of complement activation ; negative regulation of protein binding ; positive regulation of cytolysis ;
	Sources:Amigo / QuickGO
Orthologs
	3080
	n/a
	ENSG00000080910
	n/a
	P36980
	n/a
	NM_001312672 ; NM_005666
	n/a
	NP_001299601 ; NP_005657
	n/a
	Wikidata
View/Edit Human

Last updated October 17, 2024

Complement factor H-related protein 2 is a protein that in humans is encoded by the CFHR2 gene.^[3]^[4]^[5]

Related Research Articles

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<span class="mw-page-title-main">Factor H</span> Protein found in humans

Factor H (FH) is a member of the regulators of complement activation family and is a complement control protein. It is a large, soluble glycoprotein that circulates in human plasma. Its principal function is to regulate the alternative pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessing both cofactor activity for Factor I–mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3-convertase, C3bBb. Factor H exerts its protective action on self cells and self surfaces but not on the surfaces of bacteria or viruses. There are however, important exceptions, such as for example the bacterial pathogen, Neisseria meningitidis. This human pathogen has evolved mechanisms to recruit human FH and down-regulate the alternative pathway. Binding of FH permits the bacteria to proliferate in the bloodstream and cause disease.

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Complement factor H-related protein 1 is a protein that in humans is encoded by the CFHR1 gene.

Ficolin-1, and also commonly termed M-ficolin is a protein that in humans is encoded by the FCN1 gene.

Progesterone-induced-blocking factor 1 is a protein that in humans is encoded by the PIBF1 gene. It has been shown to localize to the centrosome and has also been named CEP90.

Olfactory receptor 2H2 is a protein that in humans is encoded by the OR2H2 gene.

Complement C4-A is a kind of the Complement component 4 protein that in humans is encoded by the C4A gene.

39S ribosomal protein L28, mitochondrial is a protein that in humans is encoded by the MRPL28 gene.

Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.

Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene.

Complement factor H-related protein 3 is a protein that in humans is encoded by the CFHR3 gene.

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.

Complement factor H-related protein 5 is a protein that in humans is encoded by the CFHR5 gene.

Complement factor H-related protein 4 is a protein that in humans is encoded by the CFHR4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000080910 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Skerka C, Timmann C, Horstmann RD, Zipfel PF (Jun 1992). "Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes". J Immunol. 148 (10): 3313–8. doi:10.4049/jimmunol.148.10.3313. PMID 1533657. S2CID 25372557.
↑ Skerka C, Moulds JM, Taillon-Miller P, Hourcade D, Zipfel PF (Oct 1995). "The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene". Immunogenetics. 42 (4): 268–74. doi:10.1007/bf00176444. PMID 7672821. S2CID 19760957.
↑ "Entrez Gene: CFHR2 complement factor H-related 2".

External links

Human CFHR2 genome location and CFHR2 gene details page in the UCSC Genome Browser .
Overview of all the structural information available in the PDB for UniProt : P36980 (Complement factor H-related protein 2) at the PDBe-KB .

Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?". Immunol. Today. 15 (3): 121–6. doi:10.1016/0167-5699(94)90155-4. PMID 8172644.
Hageman GS, Hancox LS, Taiber AJ, et al. (2007). "Extended Haplotypes in the Complement Factor H (CFH) and CFH-related (CFHR) Family of Genes that Protect against Age-related Macular Degeneration: Identification, Ethnic Distribution and Evolutionary Implications". Ann. Med. 38 (8): 592–604. doi:10.1080/07853890601097030. PMC 1905836 . PMID 17438673.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D (1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics. 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701. S2CID 31776506.
Skerka C, Horstmann RD, Zipfel PF (1991). "Molecular cloning of a human serum protein structurally related to complement factor H". J. Biol. Chem. 266 (18): 12015–20. doi: 10.1016/S0021-9258(18)99058-7 . PMID 1711047.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000080910 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1533657-3] Skerka C, Timmann C, Horstmann RD, Zipfel PF (Jun 1992). "Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes". J Immunol. 148 (10): 3313–8. doi:10.4049/jimmunol.148.10.3313. PMID 1533657. S2CID 25372557.

[pmid7672821-4] Skerka C, Moulds JM, Taillon-Miller P, Hourcade D, Zipfel PF (Oct 1995). "The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene". Immunogenetics. 42 (4): 268–74. doi:10.1007/bf00176444. PMID 7672821. S2CID 19760957.

[entrez-5] "Entrez Gene: CFHR2 complement factor H-related 2".

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CFHR2

Contents

Related Research Articles

References

External links

Further reading