CHKA

CHKA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CKO, 2CKP, 2CKQ, 2I7Q, 3F2R, 3G15, 3ZM9, 4BR3, 4CG8, 4CG9, 4CGA, 4DA5, 5AFV, 5EQE, 5EQP, 5EQY, 5FTG Contents Clinical significance ; References ; External links ; Further reading ;
Identifiers
Aliases	CHKA , CHK, CK, CKI, EK, choline kinase alpha
External IDs	OMIM: 118491 MGI: 107760 HomoloGene: 88575 GeneCards: CHKA
EC number	2.7.1.82
Gene location (Human)
Chr.	Chromosome 11 (human)
End	68,121,444 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	3,894,369 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of pancreas; ; gastric mucosa; ; body of stomach; ; Brodmann area 9; ; nucleus accumbens; ; cingulate gyrus; ; caudate nucleus; ; amygdala;
	Top expressed in
	spermatocyte; ; morula; ; medullary collecting duct; ; spermatid; ; superior frontal gyrus; ; submandibular gland; ; cerebellar cortex; ; duodenum; ; jejunum; ; mirror;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein homodimerization activity ; cholinesterase activity ; signal transducer activity ; choline binding ; kinase activity ; ATP binding ; ethanolamine kinase activity ; choline kinase activity ;
Cellular component	cytoplasm ; cytosol ;
Biological process	lipid transport ; ethanolamine metabolic process ; choline metabolic process ; phosphorylation ; lipid metabolism ; response to 3-methylcholanthrene ; phospholipid biosynthetic process ; response to toxic substance ; CDP-choline pathway ; signal transduction ; phosphatidylcholine biosynthetic process ; phosphatidylethanolamine biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	1119
	12660
	ENSG00000110721
	ENSMUSG00000024843
	P35790
	O54804
NM_001277 ; NM_212469 ; NM_001376219 ; NM_001376220 ; NM_001376221 ;
	NM_001376222
	NM_001025566 ; NM_001271496 ; NM_013490
NP_001268 ; NP_997634 ; NP_001363148 ; NP_001363149 ; NP_001363150 ;
	NP_001363151
	NP_001258425 ; NP_038518
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene.^[5]^[6]^[7]

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.^[7]

In melanocytic cells CHKA gene expression may be regulated by MITF.^[8]

Clinical significance

Mutations of the CHKA gene cause a neurodevelopmental disorder with epilepsy and microcephaly.^[9]

Related Research Articles

Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the MITF gene.

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene.

Choline kinase is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. This reaction involves the transfer of a phosphate group from adenosine triphosphate (ATP) to choline in order to form phosphocholine.

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.

Serine/threonine-protein kinase MARK1 is an enzyme that in humans is encoded by the MARK1 gene.

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.

Histidine triad nucleotide-binding protein 1 also known as adenosine 5'-monophosphoramidase is an enzyme that in humans is encoded by the HINT1 gene.

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

Choline kinase beta (CK), also known as Ethanolamine kinase (EK), Choline kinase-like protein , choline/ethanolamine kinase beta (CKEKB), or Choline/ethanolamine kinase is a protein encoded by the CHKB gene. This gene is found on chromosome 22 in humans. The encoded protein plays a key role in phospholipid biosynthesis. Choline kinase (CK) and ethanolamine kinase (EK) catalyzes the first step in phosphatidylethanolamine biosynthesis. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus.

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.

Fyn-related kinase is an enzyme that in humans is encoded by the FRK gene.

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.

Mitochondrial thiamine pyrophosphate carrier is a protein that in humans is encoded by the SLC25A19 gene.

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.

Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.

Tyrosine-protein kinase STYK1 is an enzyme that in humans is encoded by the STYK1 gene.

Choline transporter-like protein 2 is a protein that in humans is encoded by the SLC44A2 gene.

Dual serine/threonine and tyrosine protein kinase is an enzyme that in humans is encoded by the DSTYK gene.

Mitogen-activated protein kinase 12, also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000110721 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024843 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hosaka K, Tanaka S, Nikawa J, Yamashita S (Aug 1992). "Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation". FEBS Lett. 304 (2–3): 229–32. doi: 10.1016/0014-5793(92)80625-Q . PMID 1618328. S2CID 25275208.
↑ Aoyama C, Liao H, Ishidate K (Mar 2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397.
1 2 "Entrez Gene: CHKA choline kinase alpha".
↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID 19067971. S2CID 24698373.
↑ Klöckner C, Fernández-Murray JP, Tavasoli M, Sticht H, Stoltenburg-Didinger G, Scholle LM, Bakhtiari S, Kruer MC, Darvish H, Firouzabadi SG, Pagnozzi A, Shukla A, Girisha KM, Narayanan DL, Kaur P, Maroofian R, Zaki MS, Noureldeen MM, Merkenschlager A, Gburek-Augustat J, Cali E, Banu S, Nahar K, Efthymiou S, Houlden H, Jamra RA, Williams J, McMaster CR, Platzer K (June 2022). "Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly". Brain: A Journal of Neurology. 145 (6): 1916–1923. doi:10.1093/brain/awac074. PMC 9630884 . PMID 35202461.

External links

Human CHKA genome location and CHKA gene details page in the UCSC Genome Browser .

Spanner S, Ansell GB (1979). "Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat forebrain". Biochem. J. 178 (3): 753–60. doi:10.1042/bj1780753. PMC 1186576 . PMID 36885.
Spanner S, Ansell GB (1978). "Choline and ethanolamine kinase activity in the cytoplasm of nerve endings from rat forebrain". Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 101: 237–45. doi:10.1007/978-1-4615-9071-2_23. ISBN 978-1-4615-9073-6. PMID 208357.
Kaplan O, Cohen JS (1994). "Lymphocyte activation-31P magnetic resonance studies of energy metabolism and phospholipid pathways". ImmunoMethods. 4 (2): 139–47. doi:10.1006/immu.1994.1015. PMID 8069533.
Price DJ, Rivnay B, Fu Y, et al. (1997). "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes". J. Biol. Chem. 272 (9): 5915–20. doi: 10.1074/jbc.272.9.5915 . PMID 9038210.
Ross BM, Moszczynska A, Blusztajn JK, et al. (1997). "Phospholipid biosynthetic enzymes in human brain". Lipids. 32 (4): 351–8. doi:10.1007/s11745-997-0044-x. PMID 9113621. S2CID 4003647.
Nakagami K, Uchida T, Ohwada S, et al. (1999). "Increased choline kinase activity and elevated phosphocholine levels in human colon cancer". Jpn. J. Cancer Res. 90 (4): 419–24. doi:10.1111/j.1349-7006.1999.tb00764.x. PMC 5926083 . PMID 10363580.
Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K". Oncogene. 21 (6): 937–46. doi: 10.1038/sj.onc.1205144 . PMID 11840339.
Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Lett. 517 (1–3): 167–71. doi: 10.1016/S0014-5793(02)02614-5 . PMID 12062430. S2CID 84792445.
Ramírez de Molina A, Gutiérrez R, Ramos MA, et al. (2002). "Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy". Oncogene. 21 (27): 4317–22. doi: 10.1038/sj.onc.1205556 . PMID 12082619.
Ramírez de Molina A, Rodríguez-González A, Gutiérrez R, et al. (2002). "Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers". Biochem. Biophys. Res. Commun. 296 (3): 580–3. doi:10.1016/S0006-291X(02)00920-8. PMID 12176020.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Gallego-Ortega D, Ramirez De Molina A, Gutierrez R, et al. (2006). "Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer" (PDF). Int. J. Oncol. 29 (2): 335–40. doi: 10.3892/ijo.29.2.335 . PMID 16820874.
Enaw JO, Zhu H, Yang W, et al. (2007). "CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population". BMC Medicine. 4: 36. doi:10.1186/1741-7015-4-36. PMC 1770928 . PMID 17184542.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000110721 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024843 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1618328-5] Hosaka K, Tanaka S, Nikawa J, Yamashita S (Aug 1992). "Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation". FEBS Lett. 304 (2–3): 229–32. doi: 10.1016/0014-5793(92)80625-Q . PMID 1618328. S2CID 25275208.

[pmid15003397-6] Aoyama C, Liao H, Ishidate K (Mar 2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397.

[entrez-7] 1 2 "Entrez Gene: CHKA choline kinase alpha".

[pmid19067971-8] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID 19067971. S2CID 24698373.

[pmid35202461-9] Klöckner C, Fernández-Murray JP, Tavasoli M, Sticht H, Stoltenburg-Didinger G, Scholle LM, Bakhtiari S, Kruer MC, Darvish H, Firouzabadi SG, Pagnozzi A, Shukla A, Girisha KM, Narayanan DL, Kaur P, Maroofian R, Zaki MS, Noureldeen MM, Merkenschlager A, Gburek-Augustat J, Cali E, Banu S, Nahar K, Efthymiou S, Houlden H, Jamra RA, Williams J, McMaster CR, Platzer K (June 2022). "Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly". Brain: A Journal of Neurology. 145 (6): 1916–1923. doi:10.1093/brain/awac074. PMC 9630884 . PMID 35202461.

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CHKA

Contents

Clinical significance

Related Research Articles

References

External links

Further reading