CHST12

CHST12
Identifiers
Aliases	CHST12 , C4S-2, C4ST-2, C4ST2, carbohydrate (chondroitin 4) sulfotransferase 12, carbohydrate sulfotransferase 12
External IDs	OMIM: 610129 MGI: 1929064 HomoloGene: 69258 GeneCards: CHST12
Gene location (Human)
Chr.	Chromosome 7 (human)
End	2,448,484 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	140,511,479 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; cerebellar vermis; ; synovial joint; ; stromal cell of endometrium; ; spleen; ; blood; ; bone marrow cells; ; sural nerve; ; lower lobe of lung; ; right coronary artery;
	Top expressed in
	interventricular septum; ; ankle; ; calvaria; ; belly cord; ; white adipose tissue; ; yolk sac; ; ventromedial nucleus; ; blood; ; dorsomedial hypothalamic nucleus; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; sulfotransferase activity ; 3'-phosphoadenosine 5'-phosphosulfate binding ; chondroitin 4-sulfotransferase activity ;
Cellular component	integral component of membrane ; integral component of Golgi membrane ; Golgi membrane ; Golgi apparatus ; membrane ;
Biological process	chondroitin sulfate biosynthetic process ; dermatan sulfate biosynthetic process ; carbohydrate biosynthetic process ; carbohydrate metabolic process ; proteoglycan biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	55501
	59031
	ENSG00000136213
	ENSMUSG00000036599
	Q9NRB3
	Q99LL3
	NM_001243794 ; NM_001243795 ; NM_018641
	NM_021528
	NP_001230723 ; NP_001230724 ; NP_061111
	NP_067503
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.^[5]^[6]

Related Research Articles

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Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 is an enzyme that in humans is encoded by the B3GNT3 gene.

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Choline transporter-like protein 4 is a protein that in humans is encoded by the SLC44A4 gene.

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.

CD320 is a human gene.

Dermatan-sulfate epimerase is an enzyme that in humans is encoded by the DSE gene.

Osteomodulin is a protein that in humans is encoded by the OMD gene.

Galactose-3-O-sulfotransferase 4 is an enzyme that in humans is encoded by the GAL3ST4 gene.

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.

Carbohydrate sulfotransferase 14 is an enzyme that in humans is encoded by the CHST14 gene.

<span class="mw-page-title-main">Carbohydrate sulfotransferase</span>

Carbohydrate sulfotransferases are sulfotransferase enzymes that transfer sulfate to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.

Carbohydrate sulfotransferase 13 is a protein that is encoded in humans by the CHST13 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136213 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036599 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (Aug 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". J Biol Chem. 275 (26): 20188–96. doi: 10.1074/jbc.M002443200 . PMID 10781601.
↑ "Entrez Gene: CHST12 carbohydrate (chondroitin 4) sulfotransferase 12".

External links

Human CHST12 genome location and CHST12 gene details page in the UCSC Genome Browser .

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Mikami T, Mizumoto S, Kago N, et al. (2003). "Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis". J. Biol. Chem. 278 (38): 36115–27. doi: 10.1074/jbc.M306044200 . PMID 12847091.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136213 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036599 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10781601-5] Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (Aug 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". J Biol Chem. 275 (26): 20188–96. doi: 10.1074/jbc.M002443200 . PMID 10781601.

[entrez-6] "Entrez Gene: CHST12 carbohydrate (chondroitin 4) sulfotransferase 12".

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CHST12

Contents

Related Research Articles

References

External links

Further reading