CHST4

CHST4
Identifiers
Aliases	CHST4 , GST3, GlcNAc6ST2, HECGLCNAC6ST, LSST, carbohydrate sulfotransferase 4
External IDs	MGI: 1349479; HomoloGene: 4216; GeneCards: CHST4; OMA:CHST4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.2 Start 71,525,233 bp [1] End 71,538,748 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 D3 Start 110,755,785 bp [2] End 110,766,372 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder pancreatic ductal cell testicle islet of Langerhans mucosa of ileum body of pancreas epithelium of bronchus secondary oocyte nasal epithelium bronchial epithelial cell Top expressed in colon left colon duodenum morula urethra jejunum ileum epithelium of stomach intestinal villus secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity N-acetylglucosamine 6-O-sulfotransferase activity Cellular component integral component of membrane Golgi apparatus intrinsic component of Golgi membrane membrane Golgi membrane trans-Golgi network Biological process cell-cell signaling cell adhesion immune response O-glycan processing sulfur compound metabolic process protein sulfation inflammatory response N-acetylglucosamine metabolic process keratan sulfate biosynthetic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10164 26887 Ensembl ENSG00000140835 ENSMUSG00000035930 UniProt Q8NCG5 Q9R1I1 RefSeq (mRNA) NM_005769 NM_001166395 NM_011998 RefSeq (protein) NP_001159867 NP_005760 NP_036128 Location (UCSC) Chr 16: 71.53 – 71.54 Mb Chr 8: 110.76 – 110.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000140835 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035930 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S (Jul 1999). "Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin". J Cell Biol. 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC   2133194 . PMID   10330415.
6. "Entrez Gene: CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4".

Further reading

• Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC   240329 . PMID   1433500.
• Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC   237448 . PMID   8419650.
• Hemmerich S, Lee JK, Bhakta S, et al. (2001). "Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family". Glycobiology. 11 (1): 75–87. doi: 10.1093/glycob/11.1.75 . PMID   11181564.
• Li X, Tu L, Murphy PG, et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin". J. Leukoc. Biol. 69 (4): 565–74. doi: 10.1189/jlb.69.4.565 . PMID   11310842. S2CID   8888883.
• Yeh JC, Hiraoka N, Petryniak B, et al. (2001). "Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase". Cell. 105 (7): 957–69. doi: 10.1016/S0092-8674(01)00394-4 . PMID   11439191. S2CID   18674112.
• Uchimura K, El-Fasakhany FM, Hori M, et al. (2002). "Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression". J. Biol. Chem. 277 (6): 3979–84. doi: 10.1074/jbc.M106587200 . PMID   11726653.
• Seko A, Nagata K, Yonezawa S, Yamashita K (2003). "Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma". Glycobiology. 12 (6): 379–88. doi: 10.1093/glycob/12.6.379 . PMID   12107080.
• Akama TO, Misra AK, Hindsgaul O, Fukuda MN (2003). "Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate". J. Biol. Chem. 277 (45): 42505–13. doi: 10.1074/jbc.M207412200 . PMID   12218059.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• de Graffenried CL, Bertozzi CR (2003). "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis". J. Biol. Chem. 278 (41): 40282–95. doi: 10.1074/jbc.M304928200 . PMID   12855678.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• de Graffenried CL, Bertozzi CR (2004). "The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity". J. Biol. Chem. 279 (38): 40035–43. doi: 10.1074/jbc.M405709200 . PMID   15220337.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Timson G, Banavali S, Gutierrez MI, et al. (2006). "High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia". Cancer Lett. 242 (2): 239–44. doi:10.1016/j.canlet.2005.11.012. PMID   16386360.

External links

• CHST4 human gene location in the UCSC Genome Browser .
• CHST4 human gene details in the UCSC Genome Browser .