CHSY1

CHSY1
Identifiers
Aliases	CHSY1 , CHSY, CSS1, ChSy-1, TPBS, chondroitin sulfate synthase 1
External IDs	OMIM: 608183; MGI: 2681120; HomoloGene: 8950; GeneCards: CHSY1; OMA:CHSY1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q26.3 Start 101,175,727 bp [1] End 101,252,048 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 C Start 65,759,263 bp [2] End 65,823,546 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia decidua visceral pleura endothelial cell Epithelium of choroid plexus vena cava hair follicle cartilage tissue gingival epithelium synovial joint Top expressed in hand secondary oocyte Gonadal ridge primary oocyte endocardial cushion semi-lunar valve renal corpuscle aortic valve calvaria otolith organ More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding transferase activity acetylgalactosaminyltransferase activity glycosyltransferase activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Cellular component extracellular region integral component of membrane Golgi apparatus Golgi membrane Golgi cisterna membrane membrane Biological process proximal/distal pattern formation bone morphogenesis cartilage development chondrocyte development negative regulation of ossification sulfation positive regulation of smoothened signaling pathway response to nutrient levels chondroitin sulfate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22856 269941 Ensembl ENSG00000131873 ENSMUSG00000032640 UniProt Q86X52 Q6ZQ11 RefSeq (mRNA) NM_014918 NM_001081163 RefSeq (protein) NP_055733 NP_001074632 Location (UCSC) Chr 15: 101.18 – 101.25 Mb Chr 7: 65.76 – 65.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene. ^{[5] [6]}

CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many biologic processes, including cell proliferation and recognition, extracellular matrix deposition, and morphogenesis. ^{[7] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000131873 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032640 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. 276 (42): 38721–6. doi: 10.1074/jbc.M106871200 . PMID   11514575.
6. "Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1".
7. supplied by OMIM

External links

• Human CHSY1 genome location and CHSY1 gene details page in the UCSC Genome Browser .

Further reading

• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Yada T, Sato T, Kaseyama H, et al. (2003). "Chondroitin sulfate synthase-3. Molecular cloning and characterization". J. Biol. Chem. 278 (41): 39711–25. doi: 10.1074/jbc.M304421200 . PMID   12907687.
• Kitagawa H, Izumikawa T, Uyama T, Sugahara K (2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J. Biol. Chem. 278 (26): 23666–71. doi: 10.1074/jbc.M302493200 . PMID   12716890.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi: 10.1093/dnares/6.1.63 . PMID   10231032.