CHSY1

CHSY1
Identifiers
Aliases	CHSY1 , CHSY, CSS1, ChSy-1, TPBS, chondroitin sulfate synthase 1
External IDs	OMIM: 608183 MGI: 2681120 HomoloGene: 8950 GeneCards: CHSY1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	101,252,048 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	65,823,546 bp
RNA expression pattern
	Top expressed in
	tibia; ; visceral pleura; ; endothelial cell; ; vena cava; ; hair follicle; ; synovial joint; ; parietal pleura; ; saphenous vein; ; cancellous bone; ; periodontal fiber;
	Top expressed in
	hand; ; secondary oocyte; ; endocardial cushion; ; semi-lunar valve; ; renal corpuscle; ; aortic valve; ; calvaria; ; otolith organ; ; utricle; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding ; transferase activity ; acetylgalactosaminyltransferase activity ; glycosyltransferase activity ; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity ; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ;
Cellular component	extracellular region ; integral component of membrane ; Golgi apparatus ; Golgi membrane ; Golgi cisterna membrane ; membrane ;
Biological process	proximal/distal pattern formation ; bone morphogenesis ; cartilage development ; chondrocyte development ; negative regulation of ossification ; sulfation ; positive regulation of smoothened signaling pathway ; response to nutrient levels ; chondroitin sulfate biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	22856
	269941
	ENSG00000131873
	ENSMUSG00000032640
	Q86X52
	Q6ZQ11
	NM_014918
	NM_001081163
	NP_055733
	NP_001074632
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 26, 2022

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.^[5]^[6]

CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many biologic processes, including cell proliferation and recognition, extracellular matrix deposition, and morphogenesis.^[7]^[6]

Related Research Articles

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.

In enzymology, a N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase is an enzyme that catalyzes the chemical reaction

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Exostosin-like 3 is a protein that in humans is encoded by the EXTL3 gene.

Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene.

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.

Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.

Chondroitin sulfate synthase 2 is an enzyme that in humans is encoded by the CHPF gene.

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.

Exostosin-like 2 is a protein that in humans is encoded by the EXTL2 gene. EXTL2 Glycosyltransferase is required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.

D-glucuronyl C5-epimerase is an enzyme that in humans is encoded by the GLCE gene.

Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the CSGALNACT1 gene.

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

Carbohydrate sulfotransferase 14 is an enzyme that in humans is encoded by the CHST14 gene.

Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131873 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032640 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. 276 (42): 38721–6. doi: 10.1074/jbc.M106871200 . PMID 11514575.
1 2 "Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1".
↑ supplied by OMIM

External links

Human CHSY1 genome location and CHSY1 gene details page in the UCSC Genome Browser .

Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Yada T, Sato T, Kaseyama H, et al. (2003). "Chondroitin sulfate synthase-3. Molecular cloning and characterization". J. Biol. Chem. 278 (41): 39711–25. doi: 10.1074/jbc.M304421200 . PMID 12907687.
Kitagawa H, Izumikawa T, Uyama T, Sugahara K (2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J. Biol. Chem. 278 (26): 23666–71. doi: 10.1074/jbc.M302493200 . PMID 12716890.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi: 10.1093/dnares/6.1.63 . PMID 10231032.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131873 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032640 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11514575-5] Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. 276 (42): 38721–6. doi: 10.1074/jbc.M106871200 . PMID 11514575.

[entrez-6] 1 2 "Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1".

[7] supplied by OMIM

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CHSY1

Contents

Related Research Articles

References

External links

Further reading