CIDEB

CIDEB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D4B
Identifiers
Aliases	CIDEB , cell death-inducing DFFA-like effector b, cell death inducing DFFA like effector b
External IDs	OMIM: 604441; MGI: 1270844; HomoloGene: 7666; GeneCards: CIDEB; OMA:CIDEB - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q12 Start 24,305,096 bp [1] End 24,311,430 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C3 Start 55,991,507 bp [2] End 55,995,915 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum spleen granulocyte monocyte blood mucosa of esophagus human kidney left adrenal cortex right adrenal gland Top expressed in right kidney jejunum human kidney duodenum left lobe of liver ileum proximal tubule intestinal villus epithelium of small intestine colon More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding identical protein binding Cellular component perinuclear region of cytoplasm cytosol lipid droplet intracellular anatomical structure Biological process positive regulation of release of cytochrome c from mitochondria execution phase of apoptosis activation of cysteine-type endopeptidase activity positive regulation of cell death intrinsic apoptotic signaling pathway in response to DNA damage apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27141 12684 Ensembl ENSG00000136305 ENSG00000285199 ENSMUSG00000022219 UniProt Q9UHD4 O70303 RefSeq (mRNA) NM_014430 NM_001318807 NM_009894 NM_026804 RefSeq (protein) NP_001305736 NP_055245 NP_034024 Location (UCSC) Chr 14: 24.31 – 24.31 Mb Chr 14: 55.99 – 56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell death-inducing DFFA-like effector b, also known as CIDEB, is a human gene. ^{[5] [6] [7]}

In humans, individuals carrying rare loss of function mutations in the CIDEB gene are protected against different aetiologies of liver disease. ^[8] CIDEB knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis. The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis. In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism. ^[9] CIDEB plays a key role in determining lipid droplet size: overexpression of CIDEB in vitro results in fat accumulation by inducing larger lipid droplets, while CIDEB knock-out experiments results in accumulation of smaller lipid droplets. ^{[10] [8]}

References

1. ENSG00000285199 GRCh38: Ensembl release 89: ENSG00000136305, ENSG00000285199 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022219 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CIDEB cell death-inducing DFFA-like effector b".
6. Ye J, Zhong Li J, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P (2009). "Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B." Cell Metabolism. 9 (2): 177–190. doi: 10.1016/j.cmet.2008.12.013 . PMID   19187774.
7. Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, Pan X, Li P (May 2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta. 1801 (5): 577–86. doi:10.1016/j.bbalip.2010.01.012. PMID   20123130.
8. Verweij N, Haas ME, Nielsen JB, Sosina OA, Kim M, Akbari P, De T, Hindy G, Bovijn J, Persaud T, Miloscio L, Germino M, Panagis L, Watanabe K, Mbatchou J (2022-07-28). "Germline Mutations in CIDEB and Protection against Liver Disease". New England Journal of Medicine. 387 (4): 332–344. doi: 10.1056/NEJMoa2117872 . ISSN   0028-4793. PMID   35939579. S2CID   251143047.
9. Zhong Li J, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P (2007). "Cideb regulates diet-induced obesity, liver steatosis and insulin sensitivity by controlling lipogeneis and fatty acid oxidation". Diabetes. 56 (10): 2523–2532. doi: 10.2337/db07-0040 . PMID   17646209.
10. Xu W, Wu L, Yu M, Chen FJ, Arshad M, Xia X, Ren H, Yu J, Xu L, Xu D, Li JZ, Li P, Zhou L (2016-02-26). "Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes". The Journal of Biological Chemistry. 291 (9): 4282–4293. doi: 10.1074/jbc.M115.701094 . ISSN   1083-351X. PMC   4813457 . PMID   26733203.

Further reading

• Inohara N, Koseki T, Chen S, et al. (1998). "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor". EMBO J. 17 (9): 2526–33. doi:10.1093/emboj/17.9.2526. PMC   1170594 . PMID   9564035.
• Lugovskoy AA, Zhou P, Chou JJ, et al. (2000). "Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis". Cell. 99 (7): 747–55. doi: 10.1016/S0092-8674(00)81672-4 . PMID   10619428.
• Chen Z, Guo K, Toh SY, et al. (2000). "Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis". J. Biol. Chem. 275 (30): 22619–22. doi: 10.1074/jbc.C000207200 . PMID   10837461.
• Liang L, Zhao M, Xu Z, et al. (2003). "Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family". Biochem. J. 370 (Pt 1): 195–203. doi:10.1042/BJ20020656. PMC   1223158 . PMID   12429024.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Erdtmann L, Franck N, Lerat H, et al. (2003). "The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis" (PDF). J. Biol. Chem. 278 (20): 18256–64. doi: 10.1074/jbc.M209732200 . PMID   12595532.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Da L, Li D, Yokoyama KK, et al. (2006). "Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene". Biochem. J. 393 (Pt 3): 779–88. doi:10.1042/BJ20051027. PMC   1360731 . PMID   16248853.
• Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, Pan X, Li P, et al. (2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta. 1801 (Pt 5): 577–586. doi:10.1016/j.bbalip.2010.01.012. PMID   20123130.