CIR (gene)

CIR1
Identifiers
Aliases	CIR1 , CIR, corepressor interacting with RBPJ, 1, corepressor interacting with RBPJ
External IDs	OMIM: 605228; MGI: 1914185; HomoloGene: 3589; GeneCards: CIR1; OMA:CIR1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q31.1 Start 174,348,022 bp [1] End 174,395,712 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 C3 Start 73,113,449 bp [2] End 73,143,045 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii monocyte Achilles tendon olfactory zone of nasal mucosa sural nerve right uterine tube right lung gastric mucosa skin of leg blood Top expressed in bone marrow zygote testicle secondary oocyte granulocyte primary oocyte genital tubercle ovary ganglionic eminence muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transcription corepressor activity protein kinase binding protein-containing complex binding Cellular component cytoplasm histone deacetylase complex cytoskeleton nucleus microtubule organizing center nuclear speck centrosome protein-containing complex Biological process mRNA processing negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated RNA splicing regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9541 66935 Ensembl ENSG00000138433 ENSMUSG00000041777 UniProt Q86X95 Q9DA19 RefSeq (mRNA) NM_199075 NM_004882 NM_025854 RefSeq (protein) NP_004873 NP_080130 Location (UCSC) Chr 2: 174.35 – 174.4 Mb Chr 2: 73.11 – 73.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Corepressor interacting with RBPJ 1 is a protein that in humans is encoded by the CIR1 gene. ^{[5] [6] [7] [8]}

Interactions

CIR (gene) has been shown to interact with SNW1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000138433 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041777 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (Feb 2005). "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing". Experimental Cell Research. 303 (2): 375–87. doi:10.1016/j.yexcr.2004.10.012. PMID   15652350.
6. Zhang J, Chen H, Weinmaster G, Hayward SD (Mar 2001). "Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC". Journal of Virology. 75 (6): 2946–56. doi:10.1128/JVI.75.6.2946-2956.2001. PMC   115921 . PMID   11222720.
7. Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. Bibcode:1999PNAS...96...23H. doi: 10.1073/pnas.96.1.23 . PMC   15086 . PMID   9874765.
8. "Entrez Gene: CIR CBF1 interacting corepressor".
9. Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC   111672 . PMID   10644367.

External links

• Human CIR1 genome location and CIR1 gene details page in the UCSC Genome Browser .

Further reading

• DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP (Jan 1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system". Molecular and Cellular Biology. 7 (1): 379–87. doi:10.1128/mcb.7.1.379. PMC   365079 . PMID   3031469.
• Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC   111672 . PMID   10644367.
• Krithivas A, Young DB, Liao G, Greene D, Hayward SD (Oct 2000). "Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells". Journal of Virology. 74 (20): 9637–45. doi:10.1128/JVI.74.20.9637-9645.2000. PMC   112396 . PMID   11000236.
• Zhou S, Hayward SD (Sep 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–32. doi:10.1128/MCB.21.18.6222-6232.2001. PMC   87339 . PMID   11509665.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.