CIZ1

CIZ1
Identifiers
Aliases	CIZ1 , LSFR1, NP94, ZNF356, CDKN1A interacting zinc finger protein 1
External IDs	OMIM: 611420; MGI: 1920234; HomoloGene: 8112; GeneCards: CIZ1; OMA:CIZ1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,204,383 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,270,982 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; left ovary; ; right ovary; ; tibial nerve; ; canal of the cervix; ; body of pancreas; ; skin of leg; ; body of uterus; ; skin of abdomen; ; muscle layer of sigmoid colon;
	Top expressed in
	genital tubercle; ; neural layer of retina; ; tail of embryo; ; aortic valve; ; yolk sac; ; primary visual cortex; ; ascending aorta; ; ventricular zone; ; muscle of thigh; ; granulocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Orthologs
	25792
	68379
	ENSG00000148337
	ENSMUSG00000039205
	Q9ULV3
	n/a
NM_001131015 ; NM_001131016 ; NM_001131017 ; NM_001131018 ; NM_001257975 ;
	NM_001257976 ; NM_012127
	NM_001252534 ; NM_001252536 ; NM_001252537 ; NM_001252538 ; NM_028412 Contents Function ; Clinical significance ; Ciz1 mutant mice ; Interactions ; References ; External links ; Further reading ;
NP_001124487 ; NP_001124488 ; NP_001124489 ; NP_001124490 ; NP_001244904 ;
	NP_001244905 ; NP_036259
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 18, 2025

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.^[5]^[6]

Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.^[6]

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.^[7]

Ciz1 mutant mice

Aged (18-mo-old) Ciz1^-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age.^[8] Embryonic fibroblasts from Ciz1^-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.^[8]

Interactions

CIZ1 has been shown to interact with P21.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148337 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039205 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (October 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochemical and Biophysical Research Communications. 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.
1 2 "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".
↑ Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, et al. (November 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proceedings of the National Academy of Sciences of the United States of America. 109 (45): E3128-35. doi: 10.1073/pnas.1210107109 . PMC 3494940 . PMID 23074256.
1 2 Khan MM, Xiao J, Patel D, LeDoux MS (February 2018). "DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice". Neurobiology of Aging. 62: 180–190. doi:10.1016/j.neurobiolaging.2017.10.014. PMC 5877805 . PMID 29154038.

External links

Human CIZ1 genome location and CIZ1 gene details page in the UCSC Genome Browser .

Lukasik A, Uniewicz KA, Kulis M, Kozlowski P (January 2008). "Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog". The FEBS Journal. 275 (2): 332–40. doi: 10.1111/j.1742-4658.2007.06203.x . PMID 18081865. S2CID 35928583.
Rahman F, Ainscough JF, Copeland N, Coverley D (October 2007). "Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1". Human Mutation. 28 (10): 993–1004. doi: 10.1002/humu.20550 . PMID 17508423. S2CID 34590449.
den Hollander P, Rayala SK, Coverley D, Kumar R (November 2006). "Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action". Cancer Research. 66 (22): 11021–9. doi: 10.1158/0008-5472.CAN-06-2336 . PMID 17108141.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Coverley D, Marr J, Ainscough J (January 2005). "Ciz1 promotes mammalian DNA replication". Journal of Cell Science. 118 (Pt 1): 101–12. doi: 10.1242/jcs.01599 . PMID 15585571.
Warder DE, Keherly MJ (2004). "Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC". Journal of Biomedical Science. 10 (4): 406–17. doi:10.1159/000071160. PMID 12824700. S2CID 202648843.
Gilley J, Fried M (July 1999). "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes". Human Molecular Genetics. 8 (7): 1313–20. doi: 10.1093/hmg/8.7.1313 . PMID 10369878.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148337 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039205 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10529385-5] 1 2 Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (October 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochemical and Biophysical Research Communications. 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.

[entrez-6] 1 2 "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".

[pmid23074256-7] Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, et al. (November 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proceedings of the National Academy of Sciences of the United States of America. 109 (45): E3128-35. doi: 10.1073/pnas.1210107109 . PMC 3494940 . PMID 23074256.

[Khan_2018-8] 1 2 Khan MM, Xiao J, Patel D, LeDoux MS (February 2018). "DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice". Neurobiology of Aging. 62: 180–190. doi:10.1016/j.neurobiolaging.2017.10.014. PMC 5877805 . PMID 29154038.

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