CIZ1

CIZ1
Identifiers
Aliases	CIZ1 , LSFR1, NP94, ZNF356, CDKN1A interacting zinc finger protein 1
External IDs	OMIM: 611420 MGI: 1920234 HomoloGene: 8112 GeneCards: CIZ1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,204,383 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,380,970 bp
RNA expression pattern
	; ; ; ;
	More reference expression data
Orthologs
	25792
	68379
	ENSG00000148337
	ENSMUSG00000039205
	Q9ULV3
	n/a
NM_001131015 ; NM_001131016 ; NM_001131017 ; NM_001131018 ; NM_001257975 ;
	NM_001257976 ; NM_012127
	NM_001252534 ; NM_001252536 ; NM_001252537 ; NM_001252538 ; NM_028412 Contents Function ; Clinical significance ; Ciz1 mutant mice ; Interactions ; References ; External links ; Further reading ;
NP_001124487 ; NP_001124488 ; NP_001124489 ; NP_001124490 ; NP_001244904 ;
	NP_001244905 ; NP_036259
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 23, 2021

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.^[5]^[6]

Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.^[6]

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.^[7]

Ciz1 mutant mice

Aged (18-mo-old) Ciz1^-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age.^[8] Embryonic fibroblasts from Ciz1^-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.^[8]

Interactions

CIZ1 has been shown to interact with P21.^[5]

Related Research Articles

p21^Cip1, also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest. This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.

Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans. It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, where cells make proteins necessary for mitosis and replicate their DNA. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. Its activity is also regulated by phosphorylation. Multiple alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. The role of this protein in G1-S transition has been recently questioned as cells lacking Cdk2 are reported to have no problem during this transition.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148337 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039205 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (October 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochemical and Biophysical Research Communications. 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.
1 2 "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".
↑ Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, et al. (November 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proceedings of the National Academy of Sciences of the United States of America. 109 (45): E3128-35. doi: 10.1073/pnas.1210107109 . PMC 3494940 . PMID 23074256.
1 2 Khan MM, Xiao J, Patel D, LeDoux MS (February 2018). "DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice". Neurobiology of Aging. 62: 180–190. doi:10.1016/j.neurobiolaging.2017.10.014. PMC 5877805 . PMID 29154038.

External links

Human CIZ1 genome location and CIZ1 gene details page in the UCSC Genome Browser .

Lukasik A, Uniewicz KA, Kulis M, Kozlowski P (January 2008). "Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog". The FEBS Journal. 275 (2): 332–40. doi: 10.1111/j.1742-4658.2007.06203.x . PMID 18081865. S2CID 35928583.
Rahman F, Ainscough JF, Copeland N, Coverley D (October 2007). "Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1". Human Mutation. 28 (10): 993–1004. doi:10.1002/humu.20550. PMID 17508423. S2CID 34590449.
den Hollander P, Rayala SK, Coverley D, Kumar R (November 2006). "Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action". Cancer Research. 66 (22): 11021–9. doi: 10.1158/0008-5472.CAN-06-2336 . PMID 17108141.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Coverley D, Marr J, Ainscough J (January 2005). "Ciz1 promotes mammalian DNA replication". Journal of Cell Science. 118 (Pt 1): 101–12. doi: 10.1242/jcs.01599 . PMID 15585571.
Warder DE, Keherly MJ (2004). "Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC". Journal of Biomedical Science. 10 (4): 406–17. doi:10.1159/000071160. PMID 12824700. S2CID 202648843.
Gilley J, Fried M (July 1999). "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes". Human Molecular Genetics. 8 (7): 1313–20. doi: 10.1093/hmg/8.7.1313 . PMID 10369878.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148337 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039205 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10529385-5] 1 2 Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (October 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochemical and Biophysical Research Communications. 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.

[entrez-6] 1 2 "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".

[pmid23074256-7] Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, et al. (November 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proceedings of the National Academy of Sciences of the United States of America. 109 (45): E3128-35. doi: 10.1073/pnas.1210107109 . PMC 3494940 . PMID 23074256.

[Khan_2018-8] 1 2 Khan MM, Xiao J, Patel D, LeDoux MS (February 2018). "DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice". Neurobiology of Aging. 62: 180–190. doi:10.1016/j.neurobiolaging.2017.10.014. PMC 5877805 . PMID 29154038.

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