CKM (gene)

CKM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I0E
Identifiers
Aliases	CKM , CKMM, M-CK, creatine kinase, M-type, CPK-M
External IDs	OMIM: 123310; MGI: 88413; HomoloGene: 20432; GeneCards: CKM; OMA:CKM - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,322,875 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,156,766 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; thoracic diaphragm; ; Skeletal muscle tissue of biceps brachii; ; triceps brachii muscle; ; gastrocnemius muscle; ; deltoid muscle; ; muscle of thigh; ; glutes; ; right ventricle; ; myocardium of left ventricle;
	Top expressed in
	digastric muscle; ; muscle of thigh; ; ankle; ; sternocleidomastoid muscle; ; medial head of gastrocnemius muscle; ; vastus lateralis muscle; ; skeletal muscle tissue; ; extraocular muscle; ; temporal muscle; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; creatine kinase activity ; transferase activity, transferring phosphorus-containing groups ; nucleotide binding ; catalytic activity ; protein binding ; ATP binding ; kinase activity ;
Cellular component	cytoplasm ; cytosol ; extracellular space ;
Biological process	creatine metabolic process ; phosphocreatine biosynthetic process ; phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	1158
	12715
	ENSG00000104879
	ENSMUSG00000030399
	P06732
	P07310
	NM_001824
	NM_007710
	NP_001815
	NP_031736
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 19, 2025

Creatine kinase, muscle also known as MCK, CKMM, M-CK, and CPK-M,^[5] is a creatine kinase that in humans is encoded by the MCK gene.^[6]

Structure

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

Function

The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

Clinical significance

In heart, in addition to the MM-CK homodimer, also the heterodimer MB-CK consisting of one muscle (M-CK) and one brain-type (B-CK) subunit is expressed. The latter may be an important serum marker for myocardial infarction, if released from damaged myocardial cells into the blood where it can be detected by clinical chemistry.

Related Research Articles

<span class="mw-page-title-main">Creatine</span> Chemical compound

Creatine is an organic compound with the nominal formula (H₂N)(HN)CN(CH₃)CH₂CO₂H. It exists in various tautomers in solutions. Creatine is found in vertebrates, where it facilitates recycling of adenosine triphosphate (ATP), primarily in muscle and brain tissue. Recycling is achieved by converting adenosine diphosphate (ADP) back to ATP via donation of phosphate groups. Creatine also acts as a buffer.

<span class="mw-page-title-main">Creatine kinase</span> Class of enzymes

Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible and thus ATP can be generated from PCr and ADP.

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.

Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.

Creatine kinase, mitochondrial 1B also known as CKMT1B is one of two genes which encode the ubiquitous mitochondrial creatine kinase.

Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKG1 gene.

Creatine kinase S-type, mitochondrial is an enzyme that in humans is encoded by the CKMT2 gene.

Voltage-dependent L-type calcium channel subunit beta-2 is a protein that in humans is encoded by the CACNB2 gene.

G protein-coupled receptor kinase 4 (GRK4) is an enzyme that is encoded by the GRK4 gene in humans.

Transgelin is a protein that in humans is encoded by the TAGLN gene.

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.

Guanine nucleotide-binding protein subunit beta-4 is a protein that in humans is encoded by the GNB4 gene.

Choline kinase beta (CK), also known as Ethanolamine kinase (EK), Choline kinase-like protein , choline/ethanolamine kinase beta (CKEKB), or Choline/ethanolamine kinase is a protein encoded by the CHKB gene. This gene is found on chromosome 22 in humans. The encoded protein plays a key role in phospholipid biosynthesis. Choline kinase (CK) and ethanolamine kinase (EK) catalyzes the first step in phosphatidylethanolamine biosynthesis. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus.

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.

Theo Wallimann is a Swiss biologist who was research group leader and Adjunct-Professor at the Institute of Cell Biology ETH Zurich and later at the Institute of Molecular Health Science https://mhs.biol.ethz.ch/about-us/emeriti-formermembers/wallimann.html at the ETH Zurich at the Biology Department https://biol.ethz.ch/en/, of the ETH Zurich, Switzerland.

<span class="mw-page-title-main">CKB (gene)</span> Protein and coding gene in humans

Brain-type creatine kinase also known as CK-BB is a creatine kinase that in humans is encoded by the CKB gene.

The CPK-MB test, also known as CK-MB test, is a cardiac marker used to assist diagnoses of an acute myocardial infarction, myocardial ischemia, or myocarditis. It measures the blood level of CK-MB, the bound combination of two variants of the enzyme phosphocreatine kinase.

Myosin-15 also known as myosin, heavy chain 15 is a protein that in humans is encoded by the MYH15 gene.

Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104879 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030399 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "CKM creatine kinase, M-type [ Homo sapiens (human)". National Library of Medicine .
↑ Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (November 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. Bibcode:1982PNAS...79.6589R. doi: 10.1073/pnas.79.21.6589 . PMC 347173 . PMID 6959139.

External links

Creatine+Kinase,+MM+Form at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CKM genome location and CKM gene details page in the UCSC Genome Browser .
Overview of all the structural information available in the PDB for UniProt : P06732 (Creatine kinase M-type) at the PDBe-KB .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104879 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030399 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[CKMgene-5] "CKM creatine kinase, M-type [ Homo sapiens (human)". National Library of Medicine .

[pmid6959139-6] Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (November 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. Bibcode:1982PNAS...79.6589R. doi: 10.1073/pnas.79.21.6589 . PMC 347173 . PMID 6959139.

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