CKM (gene)

CKM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I0E
Identifiers
Aliases	CKM , CKMM, M-CK, creatine kinase, M-type, CPK-M
External IDs	OMIM: 123310 MGI: 88413 HomoloGene: 20432 GeneCards: CKM
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,322,875 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,156,766 bp
RNA expression pattern
	Top expressed in
	thoracic diaphragm; ; triceps brachii muscle; ; gastrocnemius muscle; ; deltoid muscle; ; right ventricle; ; body of tongue; ; tibialis anterior muscle; ; vena cava; ; vastus lateralis muscle; ; greater omentum;
	Top expressed in
	digastric muscle; ; ankle; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; skeletal muscle tissue; ; extraocular muscle; ; temporal muscle; ; triceps brachii muscle; ; tibialis anterior muscle; ; thoracic diaphragm;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; creatine kinase activity ; transferase activity, transferring phosphorus-containing groups ; nucleotide binding ; catalytic activity ; protein binding ; ATP binding ; kinase activity ;
Cellular component	cytoplasm ; cytosol ; extracellular space ;
Biological process	creatine metabolic process ; phosphocreatine biosynthetic process ; phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	1158
	12715
	ENSG00000104879
	ENSMUSG00000030399
	P06732
	P07310
	NM_001824
	NM_007710
	NP_001815
	NP_031736
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 08, 2023

Creatine kinase, muscle also known as MCK is a creatine kinase that in humans is encoded by the MCK gene.^[5]

Structure

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

Function

The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

Clinical significance

In heart, in addition to the MM-CK homodimer, also the heterodimer MB-CK consisting of one muscle (M-CK) and one brain-type (B-CK) subunit is expressed. The latter may be an important serum marker for myocardial infarction, if released from damaged myocardial cells into the blood where it can be detected by clinical chemistry.

Related Research Articles

<span class="mw-page-title-main">Creatine</span> Chemical compound

Creatine is an organic compound with the nominal formula (H₂N)(HN)CN(CH₃)CH₂CO₂H. It exists in various tautomers in solutions. Creatine is found in vertebrates where it facilitates recycling of adenosine triphosphate (ATP), primarily in muscle and brain tissue. Recycling is achieved by converting adenosine diphosphate (ADP) back to ATP via donation of phosphate groups. Creatine also acts as a buffer.

<span class="mw-page-title-main">Creatine kinase</span> Class of enzymes

Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible and thus ATP can be generated from PCr and ADP.

Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene. It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase.

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.

Creatine kinase, mitochondrial 1B also known as CKMT1B is one of two genes which encode the ubiquitous mitochondrial creatine kinase.

Creatine kinase S-type, mitochondrial is an enzyme that in humans is encoded by the CKMT2 gene.

Voltage-dependent L-type calcium channel subunit beta-2 is a protein that in humans is encoded by the CACNB2 gene.

Transgelin is a protein that in humans is encoded by the TAGLN gene.

Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene.

Myosin-2 is a protein that in humans is encoded by the MYH2 gene.

5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene.

Potassium-transporting ATPase alpha chain 2 is a protein that in humans is encoded by the ATP12A gene.

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. ATP1B3 has also been designated as CD298.

5'-AMP-activated protein kinase subunit gamma-3 is an enzyme that in humans is encoded by the PRKAG3 gene.

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.

Theo Wallimann is a Swiss biologist who was research group leader and Adjunct-Professor at the Institute of Cell Biology ETH Zurich and later at the Institute of Molecular Health Science at the ETH Zurich at the Biology Department, of the ETH Zurich, Switzerland.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104879 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030399 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (November 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. Bibcode:1982PNAS...79.6589R. doi: 10.1073/pnas.79.21.6589 . PMC 347173 . PMID 6959139.

External links

Creatine+Kinase,+MM+Form at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CKM genome location and CKM gene details page in the UCSC Genome Browser .
Overview of all the structural information available in the PDB for UniProt : P06732 (Creatine kinase M-type) at the PDBe-KB .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104879 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030399 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6959139-5] Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (November 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. Bibcode:1982PNAS...79.6589R. doi: 10.1073/pnas.79.21.6589 . PMC 347173 . PMID 6959139.

[1]

[2]

[3]

[4]

[5]