CKS2

For the aerodrome using the TC LID, CKS2, see Kennisis Lake/Francis Water Aerodrome.

CKS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CKS, 4Y72, 5HQ0, 4YC3
Identifiers
Aliases	CKS2 , CKSHS2, CDC28 protein kinase regulatory subunit 2
External IDs	OMIM: 116901 MGI: 1913447 HomoloGene: 86883 GeneCards: CKS2
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q22.2 Start 89,311,195 bp [1] End 89,316,703 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A5 Start 51,799,268 bp [2] End 51,804,696 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence sperm oocyte cancellous bone stromal cell of endometrium thymus secondary oocyte bone marrow rectum Left adrenal gland Top expressed in morula secondary oocyte yolk sac blastocyst thymus bone marrow spermatocyte ileum proximal tubule testicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cyclin-dependent protein serine/threonine kinase regulator activity chromatin binding histone binding protein kinase binding cyclin-dependent protein serine/threonine kinase activator activity ubiquitin binding protein binding Cellular component SCF ubiquitin ligase complex cyclin-dependent protein kinase holoenzyme complex Biological process cell cycle meiosis I cell division regulation of mitotic cell cycle positive regulation of cyclin-dependent protein serine/threonine kinase activity cell population proliferation positive regulation of transcription, DNA-templated mitotic cell cycle phase transition regulation of transcription by RNA polymerase II regulation of cyclin-dependent protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1164 66197 Ensembl ENSG00000123975 ENSMUSG00000062248 UniProt P33552 P56390 RefSeq (mRNA) NM_001827 NM_025415 RefSeq (protein) NP_001818 NP_079691 Location (UCSC) Chr 9: 89.31 – 89.32 Mb Chr 13: 51.8 – 51.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-dependent kinases regulatory subunit 2 is a protein that in humans is encoded by the CKS2 gene. ^{[5] [6] [7]}

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000123975 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062248 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Richardson HE, Stueland CS, Thomas J, Russell P, Reed SI (Dec 1990). "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe". Genes Dev. 4 (8): 1332–44. doi: 10.1101/gad.4.8.1332 . PMID   2227411.
6. Demetrick DJ, Zhang H, Beach DH (Sep 1996). "Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22". Cytogenet Cell Genet. 73 (3): 250–4. doi:10.1159/000134349. PMID   8697818.
7. "Entrez Gene: CKS2 CDC28 protein kinase regulatory subunit 2".

External links

• Human CKS2 genome location and CKS2 gene details page in the UCSC Genome Browser .

Further reading

• Parge HE, Arvai AS, Murtari DJ, et al. (1993). "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control". Science. 262 (5132): 387–95. Bibcode:1993Sci...262..387P. doi:10.1126/science.8211159. PMID   8211159.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi: 10.1074/jbc.M403080200 . PMID   15504738.
• Gorr IH, Boos D, Stemmann O (2005). "Mutual inhibition of separase and Cdk1 by two-step complex formation". Mol. Cell. 19 (1): 135–41. doi: 10.1016/j.molcel.2005.05.022 . PMID   15989971.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Rother K, Dengl M, Lorenz J, et al. (2007). "Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73". FEBS Lett. 581 (6): 1166–72. doi:10.1016/j.febslet.2007.02.028. PMID   17336302. S2CID   6953397.
• Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen". PLOS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMC   1831731 . PMID   17388661.