CLDN17

CLDN17
Identifiers
Aliases	CLDN17 , claudin 17
External IDs	OMIM: 617005 MGI: 2652030 HomoloGene: 8116 GeneCards: CLDN17
Gene location (Human)
Chr.	Chromosome 21 (human)
End	30,166,805 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	88,303,866 bp
RNA expression pattern
	Top expressed in
	cervix epithelium; ; cavity of mouth; ; human penis; ; epithelium of esophagus; ; gums; ; vagina; ; body of tongue; ; vulva; ; thymus; ; minor salivary gland;
	Top expressed in
	esophagus; ; ear; ; surface ectoderm; ; nose; ; lip; ; stomach; ; zone of skin; ; visual system; ; limb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity ; identical protein binding ; chloride channel activity ; protein binding ;
Cellular component	integral component of membrane ; cell junction ; plasma membrane ; membrane ; bicellular tight junction ; chloride channel complex ;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ; ion transport ; chloride transport ; chloride transmembrane transport ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	26285
	239931
	ENSG00000156282
	ENSMUSG00000055811
	P56750
	Q8BXA6
	NM_012131
	NM_181490
	NP_036263
	NP_852467
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Claudin-17 is a protein that in humans is encoded by the CLDN17 gene.^[5]^[6] It belongs to the group of claudins; claudins are cell-cell junction proteins that keep that maintains cell- and tissue-barrier function.^[7] It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules.^[8]^[9]

Related Research Articles

Claudins are a family of proteins which, along with occludin, are the most important components of the tight junctions. Tight junctions establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm.

Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. It belongs to the group of claudins.

Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins.

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene. It belongs to the group of claudins.

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. It is a member of the claudin protein family.

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.

Claudin-6 is a protein that in humans is encoded by the CLDN6 gene. It belongs to the group of claudins. The knockout mice of mouse homolog exhibit no phenotype, indicating that claudin-6 is dispensable for normal development and homeostasis.

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene. It belongs to the group of claudins.

Claudin-12 is a protein that in humans is encoded by the CLDN12 gene. It belongs to the group of claudins.

Claudin-8 is a protein that in humans is encoded by the CLDN8 gene. It belongs to the group of claudins.

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. It belongs to the group of claudins and was the first member of the family to be knocked out in mice, thereby demonstrating the central role of claudins for intramembranous strands observed in freeze-fracture images.

Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. It belongs to the group of claudins.

Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called claudins.

Claudin-9 is a protein that in humans is encoded by the CLDN9 gene. It belongs to the group of claudins.

Claudin-10 is a protein that in humans is encoded by the CLDN10 gene. It belongs to the group of claudins.

Claudin-15 is a protein that in humans is encoded by the CLDN15 gene. It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene. It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.

Claudin-20 is a protein that in humans is encoded by the CLDN20 gene. It belongs to the group of claudins.

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.

Claudin-22 is a protein that in humans is encoded by the CLDN22 gene. It belongs to the group of claudins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000156282 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055811 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Katoh M, Katoh M (May 2003). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int J Mol Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
↑ "Entrez Gene: CLDN17 claudin 17".
↑ Adil, MS; Narayanan, SP; Somanath, PR (2021). "Cell-cell junctions: structure and regulation in physiology and pathology". Tissue Barriers. 9 (1): 1848212. doi:10.1080/21688370.2020.1848212. PMC 7849786 . PMID 33300427.
↑ Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012). "Claudin-17 forms tight junction channels with distinct anion selectivity". Cell Mol Life Sci. 69 (16): 2765–78. doi:10.1007/s00018-012-0949-x. PMID 22402829. S2CID 18173604.
↑ Adil, M; Parvathagiri, V; Verma, A; Liu, F; Rudraraju, M; Narayanan, SP; Somanath, PR (2022). "Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress". Cells. 11 (11): 1782. doi: 10.3390/cells11111782 . PMC 9180152 . PMID 35681477.

External links

Human CLDN17 genome location and CLDN17 gene details page in the UCSC Genome Browser .

González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728 . PMID 16780588.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Brandner JM, Kief S, Grund C, et al. (2003). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes". Eur. J. Cell Biol. 81 (5): 253–63. doi:10.1078/0171-9335-00244. PMID 12067061.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID 10830953.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318 . PMID 26680015.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000156282 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055811 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12736707-5] Katoh M, Katoh M (May 2003). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int J Mol Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.

[entrez-6] "Entrez Gene: CLDN17 claudin 17".

[7] Adil, MS; Narayanan, SP; Somanath, PR (2021). "Cell-cell junctions: structure and regulation in physiology and pathology". Tissue Barriers. 9 (1): 1848212. doi:10.1080/21688370.2020.1848212. PMC 7849786 . PMID 33300427.

[8] Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012). "Claudin-17 forms tight junction channels with distinct anion selectivity". Cell Mol Life Sci. 69 (16): 2765–78. doi:10.1007/s00018-012-0949-x. PMID 22402829. S2CID 18173604.

[9] Adil, M; Parvathagiri, V; Verma, A; Liu, F; Rudraraju, M; Narayanan, SP; Somanath, PR (2022). "Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress". Cells. 11 (11): 1782. doi: 10.3390/cells11111782 . PMC 9180152 . PMID 35681477.

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CLDN17

Contents

Related Research Articles

References

External links

Further reading