CLDN17

CLDN17
Identifiers
Aliases	CLDN17 , claudin 17
External IDs	OMIM: 617005; MGI: 2652030; HomoloGene: 8116; GeneCards: CLDN17; OMA:CLDN17 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q21.3 Start 30,165,565 bp [1] End 30,166,805 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 C3.3 Start 88,302,695 bp [2] End 88,303,866 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle cervix epithelium oral cavity human penis epithelium of esophagus gums vagina body of tongue vulva gingival epithelium Top expressed in esophagus embryo ear surface ectoderm nose pharyngeal arch lip stomach zone of skin visual system More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding chloride channel activity protein binding Cellular component integral component of membrane cell junction plasma membrane membrane bicellular tight junction chloride channel complex Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ion transport chloride transport chloride transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26285 239931 Ensembl ENSG00000156282 ENSMUSG00000055811 UniProt P56750 Q8BXA6 RefSeq (mRNA) NM_012131 NM_181490 RefSeq (protein) NP_036263 NP_852467 Location (UCSC) Chr 21: 30.17 – 30.17 Mb Chr 16: 88.3 – 88.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-17 is a protein that in humans is encoded by the CLDN17 gene. ^{[5] [6]} It belongs to the group of claudins; claudins are cell-cell junction proteins that keep that maintains cell- and tissue-barrier function. ^[7] It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000156282 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055811 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh M, Katoh M (May 2003). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int J Mol Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID   12736707.
6. "Entrez Gene: CLDN17 claudin 17".
7. Adil, MS; Narayanan, SP; Somanath, PR (2021). "Cell-cell junctions: structure and regulation in physiology and pathology". Tissue Barriers. 9 (1): 1848212. doi:10.1080/21688370.2020.1848212. PMC   7849786 . PMID   33300427.
8. Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012). "Claudin-17 forms tight junction channels with distinct anion selectivity". Cell Mol Life Sci. 69 (16): 2765–78. doi:10.1007/s00018-012-0949-x. PMC   11115135 . PMID   22402829. S2CID   18173604.
9. Adil, M; Parvathagiri, V; Verma, A; Liu, F; Rudraraju, M; Narayanan, SP; Somanath, PR (2022). "Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress". Cells. 11 (11): 1782. doi: 10.3390/cells11111782 . PMC   9180152 . PMID   35681477.

External links

• Human CLDN17 genome location and CLDN17 gene details page in the UCSC Genome Browser .

Further reading

• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID   12475568.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID   12231346.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID   11283726. S2CID   36524601.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID   11247307. S2CID   12132159.
• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC   11537529 . PMID   10690502. S2CID   26473781.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi: 10.1186/1471-2164-7-155 . PMC   1526728 . PMID   16780588.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brandner JM, Kief S, Grund C, et al. (2003). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes". Eur. J. Cell Biol. 81 (5): 253–63. doi:10.1078/0171-9335-00244. PMID   12067061.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC   4777318 . PMID   26680015.