CLDN18

CLDN18
Identifiers
Aliases	CLDN18 , SFTA5, SFTPJ, claudin 18
External IDs	OMIM: 609210; MGI: 1929209; HomoloGene: 9489; GeneCards: CLDN18; OMA:CLDN18 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q22.3 Start 137,998,735 bp [1] End 138,033,655 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 E3.3 Start 99,571,514 bp [2] End 99,599,320 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pylorus lower lobe of lung cardia right lung upper lobe of lung upper lobe of left lung body of stomach gastric mucosa visceral pleura fundus Top expressed in mucous cell of stomach right lung lobe epithelium of stomach pyloric antrum left lung left lung lobe blastocyst duodenum embryo right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding Cellular component integral component of membrane cell junction plasma membrane membrane bicellular tight junction Biological process negative regulation of protein localization to nucleus TNFSF11-mediated signaling pathway calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules digestive tract development negative regulation of osteoclast development negative regulation of bone resorption response to ethanol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51208 56492 Ensembl ENSG00000066405 ENSMUSG00000032473 UniProt P56856 P56857 RefSeq (mRNA) NM_016369 NM_001002026 NM_001194921 NM_001194922 NM_001194923 NM_019815 RefSeq (protein) NP_001002026 NP_057453 NP_001181850 NP_001181851 NP_001181852 NP_062789 Location (UCSC) Chr 3: 138 – 138.03 Mb Chr 9: 99.57 – 99.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. ^[5] It belongs to the group of claudins.

CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells . ^[6] [supplied by OMIM] ^[5]

Clinical significance

Isoform 2 (Claudin 18.2) is abundant in gastric tumors. ^[7]

Zolbetuximab targets Claudin 18.2 to help treat gastric and gastroesophageal junction cancers. ^{[8] [9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000066405 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032473 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CLDN18 claudin 18".
6. Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing". Mol. Cell. Biol. 21 (21): 7380–90. doi:10.1128/MCB.21.21.7380-7390.2001. PMC   99911 . PMID   11585919.
7. Antibody Shines in Advanced Gastric Cancer - IMAB362 leads to longer remission, better survival. June 2016
8. "Astellas' VYLOY™ (zolbetuximab) Approved in Japan for Treatment of Gastric Cancer a". www.prnewswire.com. 2024-03-26. Retrieved 2024-09-29.
9. Ouladan S, Orouji E (March 2025). "CAR-T Cells in Colorectal Cancer: Pioneering New Avenues in Solid Tumor Immunotherapy". Journal of Clinical Oncology. 42 (23): 2637–2639. doi:10.1200/JCO.24.02081. PMC   11895826 . PMID   39805063.
10. Liu, Jian; Yang, Jing; Sun, Ying (July 2025). "CLDN18.2–targeting antibody–drug conjugate IBI343 in advanced gastric or gastroesophageal junction adenocarcinoma: a phase 1 trial". Nature Medicine. na (na): s41591-025-03783-8. doi: 10.1038/s41591-025-03783-8 . PMID   40670773.

External links

• Human CLDN18 genome location and CLDN18 gene details page in the UCSC Genome Browser .

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC   11537529 . PMID   10690502. S2CID   26473781.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi: 10.1034/j.1600-0854.2001.020203.x . PMID   11247307. S2CID   12132159.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID   11283726. S2CID   36524601.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID   12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi: 10.1016/S0079-6107(02)00037-8 . PMID   12475568.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.
• Matsuda Y, Semba S, Ueda J, et al. (2007). "Gastric and intestinal claudin expression at the invasive front of gastric carcinoma". Cancer Sci. 98 (7): 1014–9. doi: 10.1111/j.1349-7006.2007.00490.x . PMC   11159341 . PMID   17459057. S2CID   28029778.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC   4777318 . PMID   26680015.