CLDN22

CLDN22
Identifiers
Aliases	CLDN22 , CLDN21, claudin 22
External IDs	MGI: 1922927 HomoloGene: 129823 GeneCards: CLDN22
Gene location (Human)
Chr.	Chromosome 4 (human)
End	183,320,774 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	47,825,476 bp
Gene ontology
Molecular function	• structural molecule activity ; • identical protein binding ;
Cellular component	• cell membrane ; • integral component of membrane ; • cell junction ; • membrane ; • bicellular tight junction ;
Biological process	• calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ;
	Sources:Amigo / QuickGO
Orthologs
	53842
	75677
	ENSG00000177300
	ENSMUSG00000038064
	Q8N7P3
	Q9D7U6
	NM_001111319
	NM_029383
	NP_001104789
	NP_083659
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 25, 2021

Claudin-22 is a protein that in humans is encoded by the CLDN22 gene.^[5] It belongs to the group of claudins.

Related Research Articles

Claudins are a family of proteins which, along with occludin, are the most important components of the tight junctions. Tight junctions establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm.

Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. It belongs to the group of claudins.

Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins.

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene. It belongs to the group of claudins.

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. It is a member of the claudin protein family.

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.

Claudin-6 is a protein that in humans is encoded by the CLDN6 gene. It belongs to the group of claudins.

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene. It belongs to the group of claudins.

Claudin-12 is a protein that in humans is encoded by the CLDN12 gene. It belongs to the group of claudins.

Claudin-8 is a protein that in humans is encoded by the CLDN8 gene. It belongs to the group of claudins.

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. It belongs to the group of claudins and was the first member of the family to be knocked out in mice, thereby demonstrating the central role of claudins for intramembranous strands observed in freeze-fracture images.

Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. It belongs to the group of claudins.

Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called claudins.

Claudin-9 is a protein that in humans is encoded by the CLDN9 gene. It belongs to the group of claudins.

Claudin-17 is a protein that in humans is encoded by the CLDN17 gene. It belongs to the group of claudins. It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules.

Claudin-10 is a protein that in humans is encoded by the CLDN10 gene. It belongs to the group of claudins.

Claudin-15 is a protein that in humans is encoded by the CLDN15 gene. It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene. It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.

Claudin-20 is a protein that in humans is encoded by the CLDN20 gene. It belongs to the group of claudins.

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177300 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038064 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CLDN22 claudin 22".

External links

Human CLDN22 genome location and CLDN22 gene details page in the UCSC Genome Browser .

González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi: 10.1016/S0079-6107(02)00037-8 . PMID 12475568.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi: 10.1034/j.1600-0854.2001.020203.x . PMID 11247307. S2CID 12132159.
Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi: 10.1038/nature03466 . PMID 15815621.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318 . PMID 26680015.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177300 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038064 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLDN22 claudin 22".

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CLDN22

Contents

Related Research Articles

References

External links

Further reading