CLDN8

CLDN8
Identifiers
Aliases	CLDN8 , HEL-S-79, claudin 8
External IDs	OMIM: 611231; MGI: 1859286; HomoloGene: 8117; GeneCards: CLDN8; OMA:CLDN8 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.11 Start 30,214,006 bp [1] End 30,216,097 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 C3.3 Start 88,357,716 bp [2] End 88,360,071 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon kidney tubule parotid gland rectum renal medulla bronchial epithelial cell human kidney hair follicle skin of thigh seminal vesicula Top expressed in seminal vesicula transitional epithelium of urinary bladder vestibular membrane of cochlear duct vestibular sensory epithelium left colon right kidney submandibular gland parotid gland medullary collecting duct stria vascularis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity protein binding identical protein binding Cellular component membrane cell junction basolateral plasma membrane integral component of membrane apicolateral plasma membrane endoplasmic reticulum plasma membrane bicellular tight junction Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9073 54420 Ensembl ENSG00000156284 ENSMUSG00000050520 UniProt P56748 Q9Z260 RefSeq (mRNA) NM_199328 NM_012132 NM_018778 RefSeq (protein) NP_955360 NP_061248 Location (UCSC) Chr 21: 30.21 – 30.22 Mb Chr 16: 88.36 – 88.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-8 is a protein that in humans is encoded by the CLDN8 gene. ^{[5] [6]} It belongs to the group of claudins.

References

1. GRCh38: Ensembl release 89: ENSG00000156284 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050520 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi: 10.1073/pnas.96.2.511 . PMC   15167 . PMID   9892664.
6. "Entrez Gene: CLDN8 claudin 8".

External links

• Human CLDN8 genome location and CLDN8 gene details page in the UCSC Genome Browser .

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC   11537529 . PMID   10690502. S2CID   26473781.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID   11247307. S2CID   12132159.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID   11283726. S2CID   36524601.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID   12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID   12475568.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC   2168087 . PMID   10601346.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Brandner JM, Kief S, Grund C, et al. (2003). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes". Eur. J. Cell Biol. 81 (5): 253–63. doi:10.1078/0171-9335-00244. PMID   12067061.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID   12736707.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC   4777318 . PMID   26680015.