CLPTM1L

CLPTM1L
Identifiers
Aliases	CLPTM1L , CRR9, CLPTM1-like, CLPTM1 like
External IDs	OMIM: 612585 MGI: 2442892 HomoloGene: 12767 GeneCards: CLPTM1L
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,345,099 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,620,605 bp
Orthologs
	81037
	218335
	ENSG00000049656 ; ENSG00000274811
	ENSMUSG00000021610
	Q96KA5
	Q8BXA5
	NM_030782
	NM_146047
	NP_110409
	NP_666159
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 23, 2021

Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene.^[5]^[6] CRR9p is associated with cisplatin-induced apoptosis.^[6] CLPTM1L, which lies within a cancer susceptibility locus on chromosome 5 (5p15.33), has been found to be commonly over-expressed in lung tumors and to confer resistance to apoptosis caused by genotoxic agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL.^[7] Inhibition of CLPTM1L has been shown to inhibit oncogenic transformation and tumorigenesis caused by the KRas oncogene partially through the PI3K/Akt survival signaling axis.^[8]

Related Research Articles

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References

1 2 3 ENSG00000274811 GRCh38: Ensembl release 89: ENSG00000049656, ENSG00000274811 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021610 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CLPTM1-like".
1 2 Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y (Feb 2001). "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis". Biochem Biophys Res Commun. 280 (4): 1148–54. doi:10.1006/bbrc.2001.4250. PMID 11162647.
↑ James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M (2012). "Functional Characterization of CLPTM1L as a Lung". PLOS ONE. 7 (6): 63116. doi: 10.1371/journal.pone.0036116 . PMC 3366984 . PMID 22675468.
↑ James MA, Vikis HG, Tate E, Rymaszewski AL, et al. (2014). "CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis". Cancer Res. 74 (4): 1116–27. doi:10.1158/0008-5472.CAN-13-1617. PMC 6005686 . PMID 24366883.

External links

Human CLPTM1L genome location and CLPTM1L gene details page in the UCSC Genome Browser .

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000274811 GRCh38: Ensembl release 89: ENSG00000049656, ENSG00000274811 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021610 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLPTM1-like".

[Yamamoto-2001-6] 1 2 Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y (Feb 2001). "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis". Biochem Biophys Res Commun. 280 (4): 1148–54. doi:10.1006/bbrc.2001.4250. PMID 11162647.

[7] James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M (2012). "Functional Characterization of CLPTM1L as a Lung". PLOS ONE. 7 (6): 63116. doi: 10.1371/journal.pone.0036116 . PMC 3366984 . PMID 22675468.

[8] James MA, Vikis HG, Tate E, Rymaszewski AL, et al. (2014). "CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis". Cancer Res. 74 (4): 1116–27. doi:10.1158/0008-5472.CAN-13-1617. PMC 6005686 . PMID 24366883.

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CLPTM1L

Contents

See also

Related Research Articles

References

External links

Further reading