CLPTM1L

CLPTM1L
Identifiers
Aliases	CLPTM1L , CRR9, CLPTM1-like, CLPTM1 like
External IDs	OMIM: 612585; MGI: 2442892; HomoloGene: 12767; GeneCards: CLPTM1L; OMA:CLPTM1L - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p15.33 Start 1,317,752 bp [1] End 1,345,099 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 C1 Start 73,752,125 bp [2] End 73,768,724 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum right lobe of thyroid gland body of pancreas left lobe of thyroid gland oocyte upper lobe of left lung gonad secondary oocyte right lobe of liver body of stomach Top expressed in lacrimal gland salivary gland submandibular gland seminal vesicula parotid gland calvaria vestibular membrane of cochlear duct stroma of bone marrow crypt of lieberkuhn of small intestine medullary collecting duct More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 81037 218335 Ensembl ENSG00000049656 ENSG00000274811 ENSMUSG00000021610 UniProt Q96KA5 Q8BXA5 RefSeq (mRNA) NM_030782 NM_146047 RefSeq (protein) NP_110409 NP_666159 Location (UCSC) Chr 5: 1.32 – 1.35 Mb Chr 13: 73.75 – 73.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene. ^{[5] [6]} CRR9p is associated with cisplatin-induced apoptosis. ^[6] CLPTM1L, which lies within a cancer susceptibility locus on chromosome 5 (5p15.33), has been found to be commonly over-expressed in lung tumors and to confer resistance to apoptosis caused by genotoxic agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL. ^[7] Inhibition of CLPTM1L has been shown to inhibit oncogenic transformation and tumorigenesis caused by the KRas oncogene partially through the PI3K/Akt survival signaling axis. ^[8]

See also

• Cleft lip and palate transmembrane protein 1

References

1. ENSG00000274811 GRCh38: Ensembl release 89: ENSG00000049656, ENSG00000274811 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021610 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CLPTM1-like".
6. Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y (Feb 2001). "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis". Biochem Biophys Res Commun. 280 (4): 1148–54. doi:10.1006/bbrc.2001.4250. PMID   11162647.
7. James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M (2012). "Functional Characterization of CLPTM1L as a Lung". PLOS ONE. 7 (6): 63116. doi: 10.1371/journal.pone.0036116 . PMC   3366984 . PMID   22675468.
8. James MA, Vikis HG, Tate E, Rymaszewski AL, et al. (2014). "CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis". Cancer Res. 74 (4): 1116–27. doi:10.1158/0008-5472.CAN-13-1617. PMC   6005686 . PMID   24366883.

External links

• Human CLPTM1L genome location and CLPTM1L gene details page in the UCSC Genome Browser .

Further reading

• Truong T, Hung RJ, Amos CI, Wu X, Bickeböller H, Rosenberger A, Sauter W, Illig T, Wichmann HE, Risch A, Dienemann H, Kaaks R, Yang P, Jiang R, Wiencke JK, Wrensch M, Hansen H, Kelsey KT, Matsuo K, Tajima K, Schwartz AG, Wenzlaff A, Seow A, Ying C, Staratschek-Jox A, Nürnberg P, Stoelben E, Wolf J, Lazarus P, Muscat JE, Gallagher CJ, Zienolddiny S, Haugen A, van der Heijden HF, Kiemeney LA, Isla D, Mayordomo JI, Rafnar T, Stefansson K, Zhang ZF, Chang SC, Kim JH, Hong YC, Duell EJ, Andrew AS, Lejbkowicz F, Rennert G, Müller H, Brenner H, Le Marchand L, Benhamou S, Bouchardy C, Teare MD, Xue X, McLaughlin J, Liu G, McKay JD, Brennan P, Spitz MR (2010). "Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium". J. Natl. Cancer Inst. 102 (13): 959–71. doi:10.1093/jnci/djq178. PMC   2897877 . PMID   20548021.
• McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, McLaughlin J, Shepherd F, Montpetit A, Narod S, Krokan HE, Skorpen F, Elvestad MB, Vatten L, Njølstad I, Axelsson T, Chen C, Goodman G, Barnett M, Loomis MM, Lubiñski J, Matyjasik J, Lener M, Oszutowska D, Field J, Liloglou T, Xinarianos G, Cassidy A, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Ramón Quirós J, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Kham KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P (2008). "Lung cancer susceptibility locus at 5p15.33". Nat. Genet. 40 (12): 1404–6. doi:10.1038/ng.254. PMC   2748187 . PMID   18978790.
• Wang Y, Broderick P, Matakidou A, Eisen T, Houlston RS (2010). "Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers". Carcinogenesis. 31 (2): 234–8. doi: 10.1093/carcin/bgp287 . PMID   19955392.
• Wang Y, Broderick P, Webb E, Wu X, Vijayakrishnan J, Matakidou A, Qureshi M, Dong Q, Gu X, Chen WV, Spitz MR, Eisen T, Amos CI, Houlston RS (2008). "Common 5p15.33 and 6p21.33 variants influence lung cancer risk". Nat. Genet. 40 (12): 1407–9. doi:10.1038/ng.273. PMC   2695928 . PMID   18978787.
• Jin G, Xu L, Shu Y, Tian T, Liang J, Xu Y, Wang F, Chen J, Dai J, Hu Z, Shen H (2009). "Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population". Carcinogenesis. 30 (6): 987–90. doi: 10.1093/carcin/bgp090 . PMID   19369581.
• Broderick P, Wang Y, Vijayakrishnan J, Matakidou A, Spitz MR, Eisen T, Amos CI, Houlston RS (2009). "Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study". Cancer Res. 69 (16): 6633–41. doi:10.1158/0008-5472.CAN-09-0680. PMC   2754318 . PMID   19654303.
• Liu Z, Li G, Wei S, Niu J, Wang LE, Sturgis EM, Wei Q (2010). "Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck". Carcinogenesis. 31 (11): 1977–1981. doi:10.1093/carcin/bgq179. PMC   2966556 . PMID   20802237.
• Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Li D, Mandelson MT, Olson SH, Risch HA, Zheng W, Albanes D, Bamlet WR, Berg CD, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hassan M, Howard B, Hunter DJ, Hutchinson A, Jenab M, Kaaks R, Kooperberg C, Krogh V, Kurtz RC, Lynch SM, McWilliams RR, Mendelsohn JB, Michaud DS, Parikh H, Patel AV, Peeters PH, Rajkovic A, Riboli E, Rodriguez L, Seminara D, Shu XO, Thomas G, Tjønneland A, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wang Z, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Fraumeni JF, Hoover RN, Hartge P, Chanock SJ (2010). "A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33". Nat. Genet. 42 (3): 224–8. doi:10.1038/ng.522. PMC   2853179 . PMID   20101243.
• Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC (2009). "Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease". Mol. Psychiatry. 14 (11): 1004–16. doi:10.1038/mp.2009.10. PMC   2860783 . PMID   19204726.
• Stacey SN, Sulem P, Masson G, Gudjonsson SA, Thorleifsson G, Jakobsdottir M, Sigurdsson A, Gudbjartsson DF, Sigurgeirsson B, Benediktsdottir KR, Thorisdottir K, Ragnarsson R, Scherer D, Hemminki K, Rudnai P, Gurzau E, Koppova K, Botella-Estrada R, Soriano V, Juberias P, Saez B, Gilaberte Y, Fuentelsaz V, Corredera C, Grasa M, Höiom V, Lindblom A, Bonenkamp JJ, van Rossum MM, Aben KK, de Vries E, Santinami M, Di Mauro MG, Maurichi A, Wendt J, Hochleitner P, Pehamberger H, Gudmundsson J, Magnusdottir DN, Gretarsdottir S, Holm H, Steinthorsdottir V, Frigge ML, Blondal T, Saemundsdottir J, Bjarnason H, Kristjansson K, Bjornsdottir G, Okamoto I, Rivoltini L, Rodolfo M, Kiemeney LA, Hansson J, Nagore E, Mayordomo JI, Kumar R, Karagas MR, Nelson HH, Gulcher JR, Rafnar T, Thorsteinsdottir U, Olafsson JH, Kong A, Stefansson K (2009). "New common variants affecting susceptibility to basal cell carcinoma". Nat. Genet. 41 (8): 909–14. doi:10.1038/ng.412. PMC   2973331 . PMID   19578363.
• Turnbull C, Rapley EA, Seal S, Pernet D, Renwick A, Hughes D, Ricketts M, Linger R, Nsengimana J, Deloukas P, Huddart RA, Bishop DT, Easton DF, Stratton MR, Rahman N (2010). "Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer". Nat. Genet. 42 (7): 604–7. doi:10.1038/ng.607. PMC   3773909 . PMID   20543847.
• Landi MT, Chatterjee N, Yu K, Goldin LR, Goldstein AM, Rotunno M, Mirabello L, Jacobs K, Wheeler W, Yeager M, Bergen AW, Li Q, Consonni D, Pesatori AC, Wacholder S, Thun M, Diver R, Oken M, Virtamo J, Albanes D, Wang Z, Burdette L, Doheny KF, Pugh EW, Laurie C, Brennan P, Hung R, Gaborieau V, McKay JD, Lathrop M, McLaughlin J, Wang Y, Tsao MS, Spitz MR, Wang Y, Krokan H, Vatten L, Skorpen F, Arnesen E, Benhamou S, Bouchard C, Metspalu A, Metsapalu A, Vooder T, Nelis M, Välk K, Field JK, Chen C, Goodman G, Sulem P, Thorleifsson G, Rafnar T, Eisen T, Sauter W, Rosenberger A, Bickeböller H, Risch A, Chang-Claude J, Wichmann HE, Stefansson K, Houlston R, Amos CI, Fraumeni JF, Savage SA, Bertazzi PA, Tucker MA, Chanock S, Caporaso NE (2009). "A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma". Am. J. Hum. Genet. 85 (5): 679–91. doi:10.1016/j.ajhg.2009.09.012. PMC   2775843 . PMID   19836008.