CLSTN1

CLSTN1
Identifiers
Aliases	CLSTN1 , ALC-ALPHA, CDHR12, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2, CST-1, calsyntenin 1
External IDs	OMIM: 611321 MGI: 1929895 HomoloGene: 8814 GeneCards: CLSTN1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	9,823,984 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	149,733,356 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; postcentral gyrus; ; Brodmann area 10; ; middle temporal gyrus; ; orbitofrontal cortex; ; superior frontal gyrus; ; Brodmann area 46; ; cerebellar vermis; ; Brodmann area 9; ; entorhinal cortex;
	Top expressed in
	primary motor cortex; ; cingulate gyrus; ; prefrontal cortex; ; habenula; ; superior frontal gyrus; ; medial dorsal nucleus; ; piriform cortex; ; medial geniculate nucleus; ; subiculum; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	X11-like protein binding ; calcium ion binding ; amyloid-beta binding ; protein binding ; kinesin binding ;
Cellular component	integral component of membrane ; postsynaptic membrane ; Golgi apparatus ; cell projection ; endoplasmic reticulum membrane ; membrane ; Golgi membrane ; plasma membrane ; synapse ; extracellular region ; cell surface ; cell junction ; endoplasmic reticulum ; nucleus ; postsynaptic density ; postsynaptic endosome ; glutamatergic synapse ; GABA-ergic synapse ; integral component of postsynaptic density membrane ; integral component of spine apparatus membrane ;
Biological process	cell adhesion ; positive regulation of synaptic transmission ; regulation of cell growth ; homophilic cell adhesion via plasma membrane adhesion molecules ; positive regulation of synapse assembly ; regulation of synapse maturation ; neurotransmitter receptor transport to postsynaptic membrane ; vesicle-mediated transport in synapse ;
	Sources:Amigo / QuickGO
Orthologs
	22883
	65945
	ENSG00000171603
	ENSMUSG00000039953
	O94985
	Q9EPL2
	NM_014944 ; NM_001009566 ; NM_001302883
	NM_001290989 ; NM_023051
	NP_001009566 ; NP_001289812 ; NP_055759
	NP_001277918 ; NP_075538
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 11, 2022

Calsyntenin-1 is a protein that in humans is encoded by the CLSTN1 gene.^[5]^[6]

Clinical relevance

Mutations in this gene have been shown associated to pathogenic mechanisms of Alzheimer's disease.^[7]

Interactions

CLSTN1 has been shown to interact with APBA2 ^[8]^[9] and Amyloid precursor protein.^[8]^[9]

Related Research Articles

Beta-secretase 2 is an enzyme that cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein. BACE2 is a close homolog of BACE1.

Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator of synapse formation, neural plasticity, antimicrobial activity, and iron export. It is coded for by the gene APP and regulated by substrate presentation. APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.

Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.

<span class="mw-page-title-main">APLP1</span> Protein-coding gene in the species Homo sapiens

Amyloid-like protein 1, also known as APLP1, is a protein that in humans is encoded by the APLP1 gene. APLP1 along with APLP2 are important modulators of glucose and insulin homeostasis.

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.

Amyloid beta A4 precursor protein-binding family A member 2 is a protein that in humans is encoded by the APBA2 gene.

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein is a protein that in humans is encoded by the HERPUD1 gene.

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.

Integral membrane protein 2B is a protein that in humans is encoded by the ITM2B gene.

Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.

Amyloid beta A4 precursor protein-binding family A member 3 is a protein that in humans is encoded by the APBA3 gene.

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 is a protein that in humans is encoded by the GNG13 gene.

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.

Amyloid beta A4 precursor protein-binding family B member 3 is a protein that in humans is encoded by the APBB3 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 is a protein that in humans is encoded by the GNG4 gene.

Dermatan-sulfate epimerase is an enzyme that in humans is encoded by the DSE gene.

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.

Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171603 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039953 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.
↑ "Entrez Gene: CLSTN1 calsyntenin 1".
↑ Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC (Jul 2012). "Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production". Human Molecular Genetics. 21 (13): 2845–54. doi:10.1093/hmg/dds109. PMC 3373235 . PMID 22434822.
1 2 Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry. 278 (49): 49448–58. doi: 10.1074/jbc.M306024200 . PMID 12972431.
1 2 Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry. 279 (23): 24343–54. doi: 10.1074/jbc.M401925200 . PMID 15037614.

External links

Human CLSTN1 genome location and CLSTN1 gene details page in the UCSC Genome Browser .
Human PIK3CD genome location and PIK3CD gene details page in the UCSC Genome Browser .

Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, Indermühle M, Engel M, Cen C, Mateos JM, Streit P, Sonderegger P (Aug 2006). "Calsyntenin-1 docks vesicular cargo to kinesin-1" (PDF). Molecular Biology of the Cell. 17 (8): 3651–63. doi:10.1091/mbc.E06-02-0112. PMC 1525238 . PMID 16760430.^{[ permanent dead link ]}
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA (Jun 2004). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nature Biotechnology. 22 (6): 724–31. doi:10.1038/nbt969. PMID 15146195. S2CID 36630738.
Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry. 279 (23): 24343–54. doi: 10.1074/jbc.M401925200 . PMID 15037614.
Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry. 278 (49): 49448–58. doi: 10.1074/jbc.M306024200 . PMID 12972431.
Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542 . PMID 12421765.
Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P (Jan 2001). "Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain". Molecular and Cellular Neurosciences. 17 (1): 151–66. doi:10.1006/mcne.2000.0937. PMID 11161476. S2CID 30856590.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171603 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039953 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.

[entrez-6] "Entrez Gene: CLSTN1 calsyntenin 1".

[doi.10.1093/hmg/dds109-7] Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC (Jul 2012). "Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production". Human Molecular Genetics. 21 (13): 2845–54. doi:10.1093/hmg/dds109. PMC 3373235 . PMID 22434822.

[pmid12972431-8] 1 2 Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry. 278 (49): 49448–58. doi: 10.1074/jbc.M306024200 . PMID 12972431.

[pmid15037614-9] 1 2 Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry. 279 (23): 24343–54. doi: 10.1074/jbc.M401925200 . PMID 15037614.

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