CMLD-2

Last updated

CMLD-2
CMLD-2.svg
Identifiers
  • 5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-oxo-3-pyrrolidin-1-ylpropyl]-4-phenylchromen-2-one
CAS Number
PubChem CID
Chemical and physical data
Formula C31H31NO6
Molar mass 513.590 g·mol−1
3D model (JSmol)
  • COC1=CC=C(C=C1)C(CC(=O)N2CCCC2)C3=C(C=C(C4=C3OC(=O)C=C4C5=CC=CC=C5)OC)OC
  • InChI=1S/C31H31NO6/c1-35-22-13-11-21(12-14-22)23(17-27(33)32-15-7-8-16-32)29-25(36-2)19-26(37-3)30-24(18-28(34)38-31(29)30)20-9-5-4-6-10-20/h4-6,9-14,18-19,23H,7-8,15-17H2,1-3H3
  • Key:PROGRNRRJJYCNX-UHFFFAOYSA-N

CMLD-2 is an experimental drug which acts as an inhibitor of the RNA-binding HuR protein. Elevated levels of HuR are found in many forms of cancer, and CMLD-2 is being researched for potential applications in cancer treatment. [1] [2] [3] [4] It also has anti-inflammatory effects, and may also be useful for the treatment of neuropathic pain, [5] [6] as well as asthma, [7] and Hepatitis B. [8]

See also

References

  1. ↑ Muralidharan R, Mehta M, Ahmed R, Roy S, Xu L, Aubé J, et al. (August 2017). "HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells". Scientific Reports. 7 (1): 9694. Bibcode:2017NatSR...7.9694M. doi:10.1038/s41598-017-07787-4. PMC   5577245 . PMID   28855578.
  2. ↑ Allegri L, Baldan F, Roy S, Aubé J, Russo D, Filetti S, et al. (May 2019). "The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells". Scientific Reports. 9 (1): 7374. Bibcode:2019NatSR...9.7374A. doi:10.1038/s41598-019-43894-0. PMC   6517587 . PMID   31089242.
  3. ↑ Chaudhary S, Appadurai MI, Maurya SK, Nallasamy P, Marimuthu S, Shah A, et al. (March 2023). "MUC16 promotes triple-negative breast cancer lung metastasis by modulating RNA-binding protein ELAVL1/HUR". Breast Cancer Research. 25 (1): 25. doi: 10.1186/s13058-023-01630-7 . PMC   10012760 . PMID   36918912.
  4. ↑ Jia MY, Wu C, Fu Z, Xu WB, Liu J, Wu CY, et al. (March 2025). "Targeting the HuR/E2F7 axis synergizes with bortezomib against multiple myeloma". Acta Pharmacologica Sinica. doi: 10.1038/s41401-025-01529-3 . PMID   40133626.
  5. ↑ Kunder N, de la Peña JB, Lou TF, Chase R, Suresh P, Lawson J, et al. (December 2022). "The RNA-Binding Protein HuR Is Integral to the Function of Nociceptors in Mice and Humans". The Journal of Neuroscience. 42 (49): 9129–9141. doi:10.1523/JNEUROSCI.1630-22.2022. PMC   9761683 . PMID   36270801.
  6. ↑ Zhang J, Xu J, Li S, Chen W, Wu Y (November 2023). "Electroacupuncture Relieves HuR/KLF9-Mediated Inflammation to Enhance Neurological Repair after Spinal Cord Injury". eNeuro. 10 (11). doi:10.1523/ENEURO.0190-23.2023. PMC   10668228 . PMID   37940560.
  7. ↑ Fattahi F, Ellis JS, Sylvester M, Bahleda K, Hietanen S, Correa L, et al. (January 2022). "HuR-Targeted Inhibition Impairs Th2 Proinflammatory Responses in Asthmatic CD4+ T Cells". Journal of Immunology. 208 (1): 38–48. doi:10.4049/jimmunol.2100635. PMID   34862257.
  8. ↑ Zheng Y, Wang M, Yin J, Duan Y, Wu C, Xu Z, et al. (February 2024). "Hepatitis B virus RNAs co-opt ELAVL1 for stabilization and CRM1-dependent nuclear export". PLOS Pathogens. 20 (2): e1011999. doi: 10.1371/journal.ppat.1011999 . PMC   10866535 . PMID   38306394.
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