CNKSR1

CNKSR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WWV
Identifiers
Aliases	CNKSR1 , CNK, CNK1, connector enhancer of kinase suppressor of Ras 1
External IDs	OMIM: 603272 MGI: 2670958 HomoloGene: 4604 GeneCards: CNKSR1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,189,884 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,965,710 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right lobe of thyroid gland; ; right uterine tube; ; left lobe of thyroid gland; ; body of pancreas; ; minor salivary gland; ; vastus lateralis muscle; ; skin of abdomen; ; rectum; ; biceps brachii;
	Top expressed in
	triceps brachii muscle; ; vastus lateralis muscle; ; temporal muscle; ; gastrocnemius muscle; ; knee joint; ; sternocleidomastoid muscle; ; digastric muscle; ; tibialis anterior muscle; ; skeletal muscle tissue; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity ; protein binding ;
Cellular component	cytoplasm ; plasma membrane ; cell cortex ; membrane ; cell-cell junction ;
Biological process	Ras protein signal transduction ; Rho protein signal transduction ; transmembrane receptor protein tyrosine kinase signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	10256
	194231
	ENSG00000142675
	ENSMUSG00000028841
	Q969H4
	A2A9K7
	NM_001297647 ; NM_001297648 ; NM_006314
	NM_001081047
	NP_001284576 ; NP_001284577 ; NP_006305
	NP_001074516
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 27, 2024

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.^[5]^[6]

Function

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.^[6]

Interactions

CNKSR1 has been shown to interact with RhoD ^[7] and RASSF1.^[8]

Related Research Articles

Mitogen-activated protein kinase 8 is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene.

Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene.

Ras association domain-containing protein 1 is a protein that in humans is encoded by the RASSF1 gene.

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.

Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.

Serine/threonine-protein kinase N2 is an enzyme that in humans and Strongylocentrotus purpuratus is encoded by the PKN2 gene.

A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene.

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.

LIM and senescent cell antigen-like-containing domain protein 1 is a protein that in humans is encoded by the LIMS1 gene.

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.

RhoD is a small signaling G protein, and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOD.

Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene.

Connector enhancer of kinase suppressor of ras 2, also known as CNK homolog protein 2 (CNK2) or MAGUIN, is an enzyme that in humans is encoded by the CNKSR2 gene.

Rhophilin-1 is a protein that in humans is encoded by the RHPN1 gene.

Mitogen-activated protein kinase 12, also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142675 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028841 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell. 95 (3): 343–53. doi: 10.1016/S0092-8674(00)81766-3 . PMID 9814705. S2CID 16587330.
1 2 "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1".
↑ Jaffe AB, Aspenström P, Hall A (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169 . PMID 14749388.
↑ Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi: 10.1074/jbc.M401699200 . PMID 15075335.

External links

CNKSR1 human gene location in the UCSC Genome Browser .
CNKSR1 human gene details in the UCSC Genome Browser .

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000142675 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028841 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9814705-5] Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell. 95 (3): 343–53. doi: 10.1016/S0092-8674(00)81766-3 . PMID 9814705. S2CID 16587330.

[entrez-6] 1 2 "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1".

[pmid14749388-7] Jaffe AB, Aspenström P, Hall A (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169 . PMID 14749388.

[pmid15075335-8] Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi: 10.1074/jbc.M401699200 . PMID 15075335.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]