CNKSR1

CNKSR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WWV
Identifiers
Aliases	CNKSR1 , CNK, CNK1, connector enhancer of kinase suppressor of Ras 1
External IDs	OMIM: 603272; MGI: 2670958; HomoloGene: 4604; GeneCards: CNKSR1; OMA:CNKSR1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.11 Start 26,177,484 bp [1] End 26,189,884 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.3 Start 133,955,352 bp [2] End 133,965,710 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle right lobe of thyroid gland right uterine tube left lobe of thyroid gland body of pancreas mucosa of transverse colon minor salivary glands olfactory zone of nasal mucosa Skeletal muscle tissue of rectus abdominis Top expressed in muscle of thigh triceps brachii muscle vastus lateralis muscle temporal muscle gastrocnemius muscle knee joint sternocleidomastoid muscle medial head of gastrocnemius muscle digastric muscle tibialis anterior muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity protein binding Cellular component cytoplasm plasma membrane cell cortex membrane cell-cell junction Biological process Ras protein signal transduction Rho protein signal transduction transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10256 194231 Ensembl ENSG00000142675 ENSMUSG00000028841 UniProt Q969H4 A2A9K7 RefSeq (mRNA) NM_001297647 NM_001297648 NM_006314 NM_001081047 RefSeq (protein) NP_001284576 NP_001284577 NP_006305 NP_001074516 Location (UCSC) Chr 1: 26.18 – 26.19 Mb Chr 4: 133.96 – 133.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene. ^{[5] [6]}

Function

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. ^[6]

Interactions

CNKSR1 has been shown to interact with RhoD ^[7] and RASSF1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000142675 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028841 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell. 95 (3): 343–53. doi: 10.1016/S0092-8674(00)81766-3 . PMID   9814705. S2CID   16587330.
6. "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1".
7. Jaffe AB, Aspenström P, Hall A (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC   344169 . PMID   14749388.
8. Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi: 10.1074/jbc.M401699200 . PMID   15075335.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Therrien M, Wong AM, Kwan E, Rubin GM (1999). "Functional analysis of CNK in RAS signaling". Proc. Natl. Acad. Sci. U.S.A. 96 (23): 13259–63. Bibcode:1999PNAS...9613259T. doi: 10.1073/pnas.96.23.13259 . PMC   23935 . PMID   10557308.
• Hartsough MT, Morrison DK, Salerno M, Palmieri D, Ouatas T, Mair M, Patrick J, Steeg PS (2002). "Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway". J. Biol. Chem. 277 (35): 32389–99. doi: 10.1074/jbc.M203115200 . PMID   12105213.
• Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA (2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature. 427 (6971): 256–60. Bibcode:2004Natur.427..256M. doi:10.1038/nature02237. PMID   14724641. S2CID   4416552.
• Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC   344169 . PMID   14749388.
• Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi: 10.1074/jbc.M401699200 . PMID   15075335.
• Jaffe AB, Hall A, Schmidt A (2005). "Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho". Curr. Biol. 15 (5): 405–12. Bibcode:2005CBio...15..405J. doi: 10.1016/j.cub.2004.12.082 . PMID   15753034. S2CID   16479940.
• Ziogas A, Moelling K, Radziwill G (2005). "CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation". J. Biol. Chem. 280 (25): 24205–11. doi: 10.1074/jbc.M413327200 . PMID   15845549.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Fritz RD, Radziwill G (2006). "The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor". Biochem. Biophys. Res. Commun. 338 (4): 1906–12. doi:10.1016/j.bbrc.2005.10.168. PMID   16289034.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.

External links

• CNKSR1 human gene location in the UCSC Genome Browser .
• CNKSR1 human gene details in the UCSC Genome Browser .