CNOT10

CNOT10
Identifiers
Aliases	CNOT10 , CCR4-NOT transcription complex subunit 10
External IDs	MGI: 1926143; HomoloGene: 41040; GeneCards: CNOT10; OMA:CNOT10 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p22.3 Start 32,685,145 bp [1] End 32,773,875 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F3 Start 114,585,878 bp [2] End 114,640,184 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis testicle right uterine tube gonad ventricular zone anterior pituitary epithelium of colon ganglionic eminence mucosa of transverse colon Top expressed in otic vesicle spermatocyte spermatid hand medullary collecting duct neural layer of retina otolith organ utricle ventricular zone epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm CCR4-NOT complex cytosol membrane nucleus Biological process nuclear-transcribed mRNA poly(A) tail shortening gene silencing regulation of transcription, DNA-templated regulation of translation transcription, DNA-templated DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mRNA catabolic process negative regulation of translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25904 78893 Ensembl ENSG00000182973 ENSMUSG00000056167 UniProt Q9H9A5 Q8BH15 RefSeq (mRNA) NM_001256741 NM_001256742 NM_015442 NM_001393366 NM_001393367 NM_001393368 NM_001393369 NM_153585 RefSeq (protein) NP_001243670 NP_001243671 NP_056257 NP_705813 Location (UCSC) Chr 3: 32.69 – 32.77 Mb Chr 9: 114.59 – 114.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CCR4-NOT transcription complex subunit 10 is a protein that in humans is encoded by the CNOT10 gene. ^[5] It is a subunit of the CCR4-Not deadenylase complex.

References

1. GRCh38: Ensembl release 89: ENSG00000182973 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056167 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CCR4-NOT transcription complex subunit 10" . Retrieved 2020-04-15.

Further reading

• Mauxion F, Prève B, Séraphin B (February 2013). "C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex". RNA Biol. 10 (2): 267–76. doi:10.4161/rna.23065. PMC   3594285 . PMID   23232451.