CNOT2

CNOT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C0D, 4C0F, 5FU6, 5FU7
Identifiers
Aliases	CNOT2 , CDC36, NOT2, NOT2H, HSPC131, CCR4-NOT transcription complex subunit 2, IDNADFS
External IDs	OMIM: 604909 MGI: 1919318 HomoloGene: 40953 GeneCards: CNOT2
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q15 Start 70,243,002 bp [1] End 70,354,993 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D2 Start 116,321,066 bp [2] End 116,417,416 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte Achilles tendon nipple human penis ganglionic eminence skin of abdomen cerebellar cortex cerebellar hemisphere sperm Top expressed in ciliary body internal carotid artery external carotid artery medullary collecting duct iris primitive streak retinal pigment epithelium cumulus cell fossa thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(A)-specific ribonuclease activity transcription coregulator activity protein binding Cellular component cytoplasm membrane CCR4-NOT complex P-body CCR4-NOT core complex nucleus cytosol plasma membrane Biological process nuclear-transcribed mRNA poly(A) tail shortening negative regulation of translation regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of stem cell population maintenance negative regulation of transcription by RNA polymerase II transcription, DNA-templated multicellular organism development positive regulation of cytoplasmic mRNA processing body assembly trophectodermal cell differentiation gene silencing negative regulation of intracellular estrogen receptor signaling pathway regulation of translation nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4848 72068 Ensembl ENSG00000111596 ENSMUSG00000020166 UniProt Q9NZN8 Q8C5L3 RefSeq (mRNA) NM_001199302 NM_001199303 NM_014515 NM_001037846 NM_001037847 NM_001037848 NM_028082 NM_001359247 NM_001359248 NM_001359249 NM_001359250 NM_001359251 NM_001359252 NM_001359253 NM_001359563 RefSeq (protein) NP_001186231 NP_001186232 NP_055330 NP_001032935 NP_001032936 NP_001032937 NP_082358 NP_001346176 NP_001346177 NP_001346178 NP_001346179 NP_001346180 NP_001346181 NP_001346182 NP_001346492 Location (UCSC) Chr 12: 70.24 – 70.35 Mb Chr 10: 116.32 – 116.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene. ^{[5] [6]} It is a subunit of the CCR4-Not deadenylase complex.

References

1. GRCh38: Ensembl release 89: ENSG00000111596 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020166 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC   102560 . PMID   10637334.
6. "Entrez Gene: CNOT2 CCR4-NOT transcription complex, subunit 2".

External links

• Human CNOT2 genome location and CNOT2 gene details page in the UCSC Genome Browser .

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Zwartjes CG, Jayne S, van den Berg DL, Timmers HT (2004). "Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex". J. Biol. Chem. 279 (12): 10848–54. doi: 10.1074/jbc.M311747200 . PMID   14707134.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Shi J, Nelson MA (2005). "The cyclin-dependent kinase 11 interacts with NOT2". Biochem. Biophys. Res. Commun. 334 (4): 1310–6. doi:10.1016/j.bbrc.2005.07.026. PMID   16039607.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Jayne S, Zwartjes CG, van Schaik FM, Timmers HT (2006). "Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex". Biochem. J. 398 (3): 461–7. doi:10.1042/BJ20060406. PMC   1559471 . PMID   16712523.