CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene. [5] [6]
The protein encoded by this gene is a subunit of the CCR4-Not transcriptional regulation and deadenylase complex. The encoded protein has a 3'-5' exonuclease activity and prefers polyadenylated substates. [6]
Exonucleases are enzymes that work by cleaving nucleotides one at a time from the end (exo) of a polynucleotide chain. A hydrolyzing reaction that breaks phosphodiester bonds at either the 3′ or the 5′ end occurs. Its close relative is the endonuclease, which cleaves phosphodiester bonds in the middle (endo) of a polynucleotide chain. Eukaryotes and prokaryotes have three types of exonucleases involved in the normal turnover of mRNA: 5′ to 3′ exonuclease (Xrn1), which is a dependent decapping protein; 3′ to 5′ exonuclease, an independent protein; and poly(A)-specific 3′ to 5′ exonuclease.
Elongin A is a protein that in humans is encoded by the ELOA gene.
Three prime repair exonuclease 2 is an enzyme that in humans is encoded by the TREX2 gene.
CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. It is a subunit of the CCR4-Not deadenylase complex.
Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.
CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene. It is a subunit of the CCR4-Not deadenylase complex.
Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene.
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms have been found for this gene.
40S ribosomal protein S11 is a protein that in humans is encoded by the RPS11 gene.
40S ribosomal protein S28 is a protein that in humans is encoded by the RPS28 gene.
CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene. It is a subunit of the CCR4-Not deadenylase complex.
CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.
CCR4-NOT transcription complex subunit 3 is a protein that in humans is encoded by the CNOT3 gene. It is a subunit of the CCR4-Not deadenylase complex.
39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene.
CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.
CCR4-NOT transcription complex subunit 10 is a protein that in humans is encoded by the CNOT10 gene. It is a subunit of the CCR4-Not deadenylase complex.
CCR4-NOT transcription complex subunit 9 is a protein that in humans is encoded by the CNOT9 gene.
CCR4-NOT transcription complex subunit 11 is a protein that in humans is encoded by the CNOT11 gene. It is a subunit of the CCR4-Not deadenylase complex.
CCR4-NOT transcription complex subunit 6 like is a protein that in humans is encoded by the CNOT6L gene. It is a paralog of CNOT6 and therefore a potential subunit of the CCR4-Not deadenylase complex.
Carbon Catabolite Repression—Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. The complex has multiple enzymatic activities as both a poly(A) 3′-5′ exonuclease and a ubiquitin ligase. The complex is present both in the nucleus where it regulates transcription and in the cytoplasm where it associates with translating ribosomes and RNA processing bodies.
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