CNOT6

CNOT6
Identifiers
Aliases	CNOT6 , CCR4, Ccr4a, CCR4-NOT transcription complex subunit 6
External IDs	OMIM: 608951; MGI: 2144529; HomoloGene: 69187; GeneCards: CNOT6; OMA:CNOT6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q35.3 Start 180,494,379 bp [1] End 180,578,358 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.2 Start 49,562,330 bp [2] End 49,603,550 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell cerebellar vermis ganglionic eminence ventricular zone retinal pigment epithelium epithelium of nasopharynx trabecular bone amniotic fluid bronchial epithelial cell Top expressed in retinal pigment epithelium saccule otic vesicle ciliary body ureter medial ganglionic eminence cumulus cell superior cervical ganglion trigeminal ganglion otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(A)-specific ribonuclease activity exoribonuclease activity metal ion binding protein binding RNA binding nuclease activity exonuclease activity hydrolase activity 3'-5'-exoribonuclease activity Cellular component cytoplasm cytosol membrane CCR4-NOT complex nucleus Biological process regulation of transcription, DNA-templated nucleic acid phosphodiester bond hydrolysis transcription, DNA-templated positive regulation of cytoplasmic mRNA processing body assembly gene silencing by miRNA positive regulation of cell population proliferation exonucleolytic catabolism of deadenylated mRNA gene silencing nuclear-transcribed mRNA catabolic process, no-go decay regulation of translation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest RNA phosphodiester bond hydrolysis, exonucleolytic nuclear-transcribed mRNA poly(A) tail shortening Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57472 104625 Ensembl ENSG00000113300 ENSMUSG00000020362 UniProt Q9ULM6 Q8K3P5 RefSeq (mRNA) NM_001303241 NM_015455 NM_001370472 NM_001370473 NM_001370474 NM_001290741 NM_212484 NM_001363356 NM_001363357 RefSeq (protein) NP_001290170 NP_001357401 NP_001357402 NP_001357403 NP_001277670 NP_997649 NP_001350285 NP_001350286 Location (UCSC) Chr 5: 180.49 – 180.58 Mb Chr 11: 49.56 – 49.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene. ^{[5] [6]}

The protein encoded by this gene is a subunit of the CCR4-Not transcriptional regulation and deadenylase complex. The encoded protein has a 3'-5' exonuclease activity and prefers polyadenylated substates. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000113300 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020362 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen J, Chiang YC, Denis CL (Mar 2002). "CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase". EMBO J. 21 (6): 1414–26. doi:10.1093/emboj/21.6.1414. PMC   125924 . PMID   11889047.
6. "Entrez Gene: CNOT6 CCR4-NOT transcription complex, subunit 6".

External links

• Human CCR4 genome location and CCR4 gene details page in the UCSC Genome Browser .
• Human CNOT6 genome location and CNOT6 gene details page in the UCSC Genome Browser .

Further reading

• Okubo K, Itoh K, Fukushima A, et al. (1996). "Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles". Genomics. 30 (2): 178–86. doi:10.1006/geno.1995.9887. PMID   8586417.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
• Albert TK, Lemaire M, van Berkum NL, et al. (2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC   102560 . PMID   10637334.
• Dupressoir A, Morel AP, Barbot W, et al. (2003). "Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding". BMC Genomics. 2: 9. doi: 10.1186/1471-2164-2-9 . PMC   61044 . PMID   11747467.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Chang TC, Yamashita A, Chen CY, et al. (2004). "UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant". Genes Dev. 18 (16): 2010–23. doi:10.1101/gad.1219104. PMC   514181 . PMID   15314026.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.