COG1

COG1
Identifiers
Aliases	COG1 , CDG2G, LDLB, component of oligomeric golgi complex 1
External IDs	OMIM: 606973 MGI: 1333873 HomoloGene: 8411 GeneCards: COG1
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q25.1 Start 73,193,055 bp [1] End 73,208,507 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E2 Start 113,539,995 bp [2] End 113,557,880 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary Brodmann area 9 nucleus accumbens prefrontal cortex cingulate gyrus caudate nucleus body of pancreas left ventricle gastrocnemius muscle right uterine tube Top expressed in external carotid artery internal carotid artery motor neuron substantia nigra islet of Langerhans seminiferous tubule Paneth cell right ventricle paraventricular nucleus of hypothalamus submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component Golgi membrane Golgi apparatus membrane trans-Golgi network membrane Golgi transport complex Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport Golgi organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9382 16834 Ensembl ENSG00000166685 ENSMUSG00000018661 UniProt Q8WTW3 Q9Z160 RefSeq (mRNA) NM_018714 NM_013581 RefSeq (protein) NP_061184 NP_038609 Location (UCSC) Chr 17: 73.19 – 73.21 Mb Chr 11: 113.54 – 113.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene. ^{[5] [6]}

The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. ^[6]

Interactions

COG1 has been shown to interact with COG4 ^[7] and COG3. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000166685 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018661 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chatterton JE, Hirsch D, Schwartz JJ, Bickel PE, Rosenberg RD, Lodish HF, Krieger M (Mar 1999). "Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex". Proc Natl Acad Sci U S A. 96 (3): 915–20. Bibcode:1999PNAS...96..915C. doi: 10.1073/pnas.96.3.915 . PMC   15325 . PMID   9927668.
6. "Entrez Gene: COG1 component of oligomeric golgi complex 1".
7. Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. United States. 279 (23): 24640–8. doi: 10.1074/jbc.M400662200 . ISSN   0021-9258. PMID   15047703.
8. Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. United States. 277 (24): 21955–61. doi: 10.1074/jbc.M202326200 . ISSN   0021-9258. PMID   11929878.

Further reading

• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
• Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi: 10.1074/jbc.M202326200 . PMID   11929878.
• Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J. Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC   2173297 . PMID   11980916.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi: 10.1074/jbc.M400662200 . PMID   15047703.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ungar D, Oka T, Vasile E, et al. (2005). "Subunit architecture of the conserved oligomeric Golgi complex". J. Biol. Chem. 280 (38): 32729–35. doi: 10.1074/jbc.M504590200 . PMID   16020545.
• Vasile E, Oka T, Ericsson M, et al. (2006). "IntraGolgi distribution of the Conserved Oligomeric Golgi (COG) complex". Exp. Cell Res. 312 (16): 3132–41. doi:10.1016/j.yexcr.2006.06.005. PMID   16857184.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
• Human COG1 genome location and COG1 gene details page in the UCSC Genome Browser .