COG2

COG2
Identifiers
Aliases	COG2 , LDLC, component of oligomeric golgi complex 2, CDG2Q
External IDs	OMIM: 606974; MGI: 1923582; HomoloGene: 7206; GeneCards: COG2; OMA:COG2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q42.2 Start 230,642,481 bp [1] End 230,693,982 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E2 Start 125,247,506 bp [2] End 125,278,747 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum right hemisphere of cerebellum right adrenal cortex pancreatic ductal cell islet of Langerhans gonad left adrenal gland left adrenal cortex granulocyte tibialis anterior muscle Top expressed in yolk sac lens granulocyte spermatocyte right kidney neural layer of retina epithelium of stomach muscle of thigh proximal tubule spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein-containing complex binding Cellular component Golgi transport complex cytosol Golgi membrane Golgi stack Golgi apparatus membrane trans-Golgi network membrane Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport Golgi organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22796 76332 Ensembl ENSG00000135775 ENSMUSG00000031979 UniProt Q14746 Q921L5 RefSeq (mRNA) NM_007357 NM_001145036 NM_029746 RefSeq (protein) NP_001138508 NP_031383 NP_084022 Location (UCSC) Chr 1: 230.64 – 230.69 Mb Chr 8: 125.25 – 125.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene. ^{[5] [6]}

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002). ^[6]

Interactions

COG2 has been shown to interact with COG4 ^[7] and COG3. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000135775 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031979 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Podos SD, Reddy P, Ashkenas J, Krieger M (Dec 1994). "LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function". J Cell Biol. 127 (3): 679–91. doi:10.1083/jcb.127.3.679. PMC   2120235 . PMID   7962052.
6. "Entrez Gene: COG2 component of oligomeric golgi complex 2".
7. Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi: 10.1074/jbc.M400662200 . ISSN   0021-9258. PMID   15047703.
8. Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi: 10.1074/jbc.M202326200 . ISSN   0021-9258. PMID   11929878.

External links

• Human COG2 genome location and COG2 gene details page in the UCSC Genome Browser .

Further reading

• Salesiotis AN, Wang CK, Wang CD, et al. (1995). "Identification of novel genes from stomach cancer cell lines by differential display". Cancer Lett. 91 (1): 47–54. doi:10.1016/0304-3835(95)03717-B. PMID   7750094.
• Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi: 10.1074/jbc.M202326200 . PMID   11929878.
• Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J. Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC   2173297 . PMID   11980916.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi: 10.1074/jbc.M400662200 . PMID   15047703.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Sohda M, Misumi Y, Yoshimura S, et al. (2007). "The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity". Traffic. 8 (3): 270–84. doi: 10.1111/j.1600-0854.2006.00530.x . PMID   17274799.