COPS7A

COPS7A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D10, 4D18, 4WSN
Identifiers
Aliases	COPS7A , CSN7A, SGN7a, CSN7, COP9 signalosome subunit 7A
External IDs	OMIM: 616009 MGI: 1349400 HomoloGene: 22685 GeneCards: COPS7A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,731,875 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,942,501 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; stromal cell of endometrium; ; cingulate gyrus; ; Brodmann area 9; ; right adrenal gland; ; gastrocnemius muscle; ; amygdala; ; anterior pituitary; ; thoracic aorta; ; left adrenal gland;
	Top expressed in
	spermatocyte; ; spermatid; ; yolk sac; ; superior frontal gyrus; ; lip; ; cerebellar cortex; ; morula; ; seminiferous tubule; ; skeletal muscle tissue; ; gallbladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	COP9 signalosome ; nucleus ; nucleoplasm ; cytoplasm ; cytosol ;
Biological process	transcription-coupled nucleotide-excision repair ; nucleotide-excision repair, DNA damage recognition ; protein deneddylation ; post-translational protein modification ; viral process ; COP9 signalosome assembly ;
	Sources:Amigo / QuickGO
Orthologs
	50813
	26894
	ENSG00000111652
	ENSMUSG00000030127
	Q9UBW8
	Q9CZ04
	NM_001164093 ; NM_001164094 ; NM_001164095 ; NM_016319
NM_001164089 ; NM_012003 ; NM_001355541 ; NM_001355542 ; NM_001379119 ;
	NM_001379120 ; NM_001379122 ; NM_001379123 ; NM_001379124 ; NM_001379125 Contents References ; External links ; Further reading ;
	NP_001157565 ; NP_001157566 ; NP_001157567 ; NP_057403
NP_001157561 ; NP_036133 ; NP_001342470 ; NP_001342471 ; NP_001366048 ;
	NP_001366049 ; NP_001366051 ; NP_001366052 ; NP_001366053 ; NP_001366054
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2024

COP9 signalosome complex subunit 7a is a protein that in humans is encoded by the COPS7A gene.^[5]

Related Research Articles

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COP9 signalosome (CSN) is a protein complex with isopeptidase activity. It catalyses the hydrolysis of NEDD8 protein from the cullin subunit of Cullin-RING ubiquitin ligases (CRL). Therefore, it is responsible for CRL deneddylation – at the same time, it is able to bind denedyllated cullin-RING complex and retain them in deactivated form. COP9 signalosome thus serves as a sole deactivator of CRLs. The complex was originally identified in plants, and subsequently found in all eukaryotic organisms including human. Human COP9 signalosome consists of 8 subunits - CSN1, CSN2, CSN3, CSN4, CSN5, CSN6, CSN7, CSN8. All are essential for full function of the complex and mutation in some of them is lethal in mice.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111652 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030127 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: COPS7A COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)".

External links

Human COPS7A genome location and COPS7A gene details page in the UCSC Genome Browser .

Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295. S2CID 37458780.
Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, et al. (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi: 10.1096/fasebj.12.6.469 . PMID 9535219. S2CID 25424324.
Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. Bibcode:1998CBio....8..919W. doi: 10.1016/S0960-9822(07)00372-7 . PMID 9707402. S2CID 13873982.
Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508 . PMID 11285227.
Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci...292.1382L. doi:10.1126/science.1059780. PMID 11337588. S2CID 14224920.
Wang Y, Devereux W, Stewart TM, Casero RA (2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". Biochem. J. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765 . PMID 12020345.
Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi: 10.1016/S0014-5793(02)03147-2 . PMID 12220626. S2CID 39308598.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, et al. (2003). "Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex". Plant Cell. 15 (3): 719–31. doi:10.1105/tpc.009092. PMC 150025 . PMID 12615944.
Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech-Otschir D, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC 151059 . PMID 12628923.
Groisman R, Polanowska J, Kuraoka I, Sawada JI, Saijo M, Drapkin R, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi: 10.1016/S0092-8674(03)00316-7 . PMID 12732143. S2CID 11639677.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111652 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030127 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: COPS7A COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)".

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COPS7A

Contents

Related Research Articles

References

External links

Further reading