COPS7B

COPS7B
Identifiers
Aliases	COPS7B , CSN7B, SGN7b, COP9 signalosome subunit 7B
External IDs	OMIM: 616010 MGI: 1349388 HomoloGene: 8068 GeneCards: COPS7B
Gene location (Human)
Chr.	Chromosome 2 (human)
End	231,809,254 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; canal of the cervix; ; left adrenal gland; ; stromal cell of endometrium; ; right lobe of thyroid gland; ; body of stomach; ; right coronary artery; ; minor salivary gland; ; tibial nerve;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; COP9 signalosome ; nucleus ; nucleoplasm ; cytosol ;
Biological process	transcription-coupled nucleotide-excision repair ; nucleotide-excision repair, DNA damage recognition ; protein deneddylation ; post-translational protein modification ; viral process ; COP9 signalosome assembly ;
	Sources:Amigo / QuickGO
Orthologs
	64708
	26895
	ENSG00000144524
	n/a
	Q9H9Q2
	Q8BV13
NM_001282949 ; NM_001282950 ; NM_001282951 ; NM_001282952 ; NM_001308381 ;
	NM_022730 ; NM_001369483
	NM_172974 ; NM_001360887 ; NM_001360888
NP_001269878 ; NP_001269879 ; NP_001269880 ; NP_001269881 ; NP_001295310 ;
	NP_073567 ; NP_001356412
	NP_766562 ; NP_001347816 ; NP_001347817
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2024

COP9 signalosome complex subunit 7b is a protein that in humans is encoded by the COPS7B gene.^[4]^[5]

Related Research Articles

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COP9 signalosome (CSN) is a protein complex with isopeptidase activity. It catalyses the hydrolysis of NEDD8 protein from the cullin subunit of Cullin-RING ubiquitin ligases (CRL). Therefore, it is responsible for CRL deneddylation – at the same time, it is able to bind denedyllated cullin-RING complex and retain them in deactivated form. COP9 signalosome thus serves as a sole deactivator of CRLs. The complex was originally identified in plants, and subsequently found in all eukaryotic organisms including human. Human COP9 signalosome consists of 8 subunits - CSN1, CSN2, CSN3, CSN4, CSN5, CSN6, CSN7, CSN8. All are essential for full function of the complex and mutation in some of them is lethal in mice.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000144524 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (Oct 1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr Biol. 8 (16): 919–22. Bibcode:1998CBio....8..919W. doi: 10.1016/S0960-9822(07)00372-7 . PMID 9707402. S2CID 13873982.
↑ "Entrez Gene: COPS7B COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)".

External links

Human COPS7B genome location and COPS7B gene details page in the UCSC Genome Browser .

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508 . PMID 11285227.
Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci...292.1382L. doi:10.1126/science.1059780. PMID 11337588. S2CID 14224920.
Wang Y, Devereux W, Stewart TM, Casero RA (2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". Biochem. J. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765 . PMID 12020345.
Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi: 10.1016/S0014-5793(02)03147-2 . PMID 12220626. S2CID 39308598.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Uhle S, Medalia O, Waldron R, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC 151059 . PMID 12628923.
Groisman R, Polanowska J, Kuraoka I, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi: 10.1016/S0092-8674(03)00316-7 . PMID 12732143. S2CID 11639677.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000144524 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9707402-4] Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (Oct 1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr Biol. 8 (16): 919–22. Bibcode:1998CBio....8..919W. doi: 10.1016/S0960-9822(07)00372-7 . PMID 9707402. S2CID 13873982.

[entrez-5] "Entrez Gene: COPS7B COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)".

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COPS7B

Contents

Related Research Articles

References

External links

Further reading