COPS7B

COPS7B
Identifiers
Aliases	COPS7B , CSN7B, SGN7b, COP9 signalosome subunit 7B
External IDs	OMIM: 616010; MGI: 1349388; HomoloGene: 8068; GeneCards: COPS7B; OMA:COPS7B - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.1 Start 231,781,671 bp [1] End 231,809,254 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right testis left testis body of uterus anterior pituitary right adrenal cortex apex of heart canal of the cervix left adrenal gland stromal cell of endometrium n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm COP9 signalosome nucleus nucleoplasm cytosol Biological process transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA damage recognition protein deneddylation post-translational protein modification viral process COP9 signalosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64708 26895 Ensembl ENSG00000144524 n/a UniProt Q9H9Q2 Q8BV13 RefSeq (mRNA) NM_001282949 NM_001282950 NM_001282951 NM_001282952 NM_001308381 NM_022730 NM_001369483 NM_172974 NM_001360887 NM_001360888 RefSeq (protein) NP_001269878 NP_001269879 NP_001269880 NP_001269881 NP_001295310 NP_073567 NP_001356412 NP_766562 NP_001347816 NP_001347817 Location (UCSC) Chr 2: 231.78 – 231.81 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

COP9 signalosome complex subunit 7b is a protein that in humans is encoded by the COPS7B gene. ^{[4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000144524 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (Oct 1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr Biol. 8 (16): 919–22. Bibcode:1998CBio....8..919W. doi: 10.1016/S0960-9822(07)00372-7 . PMID   9707402. S2CID   13873982.
5. "Entrez Gene: COPS7B COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)".

External links

• Human COPS7B genome location and COPS7B gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC   145508 . PMID   11285227.
• Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci...292.1382L. doi:10.1126/science.1059780. PMID   11337588. S2CID   14224920.
• Wang Y, Devereux W, Stewart TM, Casero RA (2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". Biochem. J. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC   1222765 . PMID   12020345.
• Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi: 10.1016/S0014-5793(02)03147-2 . PMID   12220626. S2CID   39308598.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Uhle S, Medalia O, Waldron R, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC   151059 . PMID   12628923.
• Groisman R, Polanowska J, Kuraoka I, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi: 10.1016/S0092-8674(03)00316-7 . PMID   12732143. S2CID   11639677.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.