CORO1B

Last updated
coronin, actin binding protein, 1B
Identifiers
SymbolCORO1B
NCBI gene 57175
HGNC 2253
OMIM 609849
RefSeq NM_020441
UniProt Q9BR76
Other data
Locus Chr. 11 q13.1

Coronin, actin binding protein, 1B also known as CORO1B is a protein which in humans is encoded by the CORO1B gene. [1] Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility. [2]

Function

A mammalian coronin enriches at the leading edge of migrating cells. [3] Studies related to this protein are as follows:

Related Research Articles

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CORO2A protein-coding gene in the species Homo sapiens

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References

  1. Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (September 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID   9778037.
  2. 1 2 Cai L, Holoweckyj N, Schaller MD, Bear JE (September 2005). "Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility". J. Biol. Chem. 280 (36): 31913–23. doi: 10.1074/jbc.M504146200 . PMID   16027158.
  3. "Entrez Gene: CORO1B coronin, actin binding protein, 1B".
  4. Cai L, Makhov AM, Schafer DA, Bear JE (September 2008). "Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia". Cell. 134 (5): 828–42. doi:10.1016/j.cell.2008.06.054. PMC   2570342 . PMID   18775315.
  5. Cai L, Makhov AM, Bear JE (May 2007). "F-actin binding is essential for coronin 1B function in vivo". J. Cell Sci. 120 (Pt 10): 1779–90. doi: 10.1242/jcs.007641 . PMID   17456547.
  6. Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE (March 2007). "Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge". Cell. 128 (5): 915–29. doi:10.1016/j.cell.2007.01.031. PMC   2630706 . PMID   17350576.
  7. Di Giovanni S, De Biase A, Yakovlev A, Finn T, Beers J, Hoffman EP, Faden AI (January 2005). "In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury". J. Biol. Chem. 280 (3): 2084–91. doi: 10.1074/jbc.M411975200 . PMID   15522871.
  8. Parente JA, Chen X, Zhou C, Petropoulos AC, Chew CS (January 1999). "Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway". J. Biol. Chem. 274 (5): 3017–25. doi: 10.1074/jbc.274.5.3017 . PMID   9915840.