COX7A1

COX7A1
Identifiers
Aliases	COX7A1 , COX7A, COX7AH, COX7AM, cytochrome c oxidase subunit 7A1
External IDs	OMIM: 123995; MGI: 1316714; HomoloGene: 48051; GeneCards: COX7A1; OMA:COX7A1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.12 Start 36,150,922 bp [1] End 36,152,449 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 B1|7 17.31 cM Start 29,883,569 bp [2] End 29,885,503 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle apex of heart myocardium of left ventricle thoracic diaphragm right auricle of heart muscle of thigh biceps brachii gastrocnemius muscle Skeletal muscle tissue of biceps brachii vastus lateralis muscle Top expressed in myocardium of ventricle cardiac muscle tissue of left ventricle interventricular septum digastric muscle intercostal muscle right ventricle temporal muscle muscle of thigh sternocleidomastoid muscle thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function electron transfer activity cytochrome-c oxidase activity Cellular component integral component of membrane mitochondrial inner membrane membrane mitochondrion mitochondrial respirasome Biological process generation of precursor metabolites and energy proton transmembrane transport electron transport chain regulation of oxidative phosphorylation mitochondrial respirasome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1346 12865 Ensembl ENSG00000161281 ENSMUSG00000074218 UniProt P24310 P56392 RefSeq (mRNA) NM_001864 NM_009944 RefSeq (protein) NP_001855 NP_034074 Location (UCSC) Chr 19: 36.15 – 36.15 Mb Chr 7: 29.88 – 29.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene. ^{[5] [6] [7]}

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000161281 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074218 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA (Nov 1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase". Gene. 119 (2): 299–305. doi: 10.1016/0378-1119(92)90287-Y . PMID   1327965.
6. Fabrizi GM, Rizzuto R, Nakase H, Mita S, Lomax MI, Grossman LI, Schon EA (Oct 1989). "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase". Nucleic Acids Res. 17 (17): 7107. doi:10.1093/nar/17.17.7107. PMC   318441 . PMID   2550906.
7. "Entrez Gene: COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)".

External links

• Human COX7A1 genome location and COX7A1 gene details page in the UCSC Genome Browser .

Further reading

• Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 61: 309–344. doi: 10.1016/S0079-6603(08)60830-2 . ISBN   978-0-12-540061-9. PMID   9752724.
• Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO (1992). "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart". Eur. J. Biochem. 203 (1–2): 193–199. doi:10.1111/j.1432-1033.1992.tb19847.x. PMID   1309697.
• Wolz W, Kress W, Mueller CR (1998). "Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M". Genomics. 45 (2): 438–442. doi:10.1006/geno.1997.4937. PMID   9344674.
• Schmidt TR, Goodman M, Grossman LI (1999). "Molecular evolution of the COX7A gene family in primates". Mol. Biol. Evol. 16 (5): 619–26. doi: 10.1093/oxfordjournals.molbev.a026144 . PMID   10335655.
• Yu M, Jaradat SA, Grossman LI (2002). "Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH)". Biochim. Biophys. Acta. 1574 (3): 345–53. doi:10.1016/s0167-4781(02)00228-2. PMID   11997101.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–535. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.