CPD (gene)

CPD
Identifiers
Aliases	CPD , GP180, carboxypeptidase D
External IDs	OMIM: 603102 MGI: 107265 HomoloGene: 999 GeneCards: CPD
Gene location (Human)
Chr.	Chromosome 17 (human)
End	30,469,989 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	76,737,844 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; islet of Langerhans; ; bronchial epithelial cell; ; Achilles tendon; ; pancreatic ductal cell; ; sperm; ; gallbladder; ; stromal cell of endometrium; ; palpebral conjunctiva; ; trachea;
	Top expressed in
	submandibular gland; ; parotid gland; ; lacrimal gland; ; epithelium of stomach; ; mucous cell of stomach; ; left colon; ; stria vascularis; ; corneal stroma; ; seminal vesicula; ; pyloric antrum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	carboxypeptidase activity ; zinc ion binding ; peptidase activity ; hydrolase activity ; metallopeptidase activity ; metal ion binding ; metallocarboxypeptidase activity ; serine-type carboxypeptidase activity ;
Cellular component	integral component of membrane ; plasma membrane ; extracellular exosome ; membrane ; extracellular space ;
Biological process	protein processing ; peptide metabolic process ; proteolysis ;
	Sources:Amigo / QuickGO
Orthologs
	1362
	12874
	ENSG00000108582
	ENSMUSG00000020841
	O75976
	O89001
	NM_001199775 ; NM_001304
	NM_007754
	NP_001186704 ; NP_001295
	NP_031780
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 14, 2024

Carboxypeptidase D is an enzyme that in humans is encoded by the CPD gene.^[5]^[6]^[7]

Function

The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities: the pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000108582 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020841 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Riley DA, Tan F, Miletich DJ, Skidgel RA (May 1998). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1)". Genomics. 50 (1): 105–8. doi:10.1006/geno.1998.5295. PMID 9628828.
↑ Tan F, Rehli M, Krause SW, Skidgel RA (Oct 1997). "Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains". The Biochemical Journal. 327 ( Pt 1) (Pt 1): 81–7. doi:10.1042/bj3270081. PMC 1218766 . PMID 9355738.
1 2 "Entrez Gene: CPD carboxypeptidase D".

External links

Human CPD genome location and CPD gene details page in the UCSC Genome Browser .

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000108582 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020841 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9628828-5] Riley DA, Tan F, Miletich DJ, Skidgel RA (May 1998). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1)". Genomics. 50 (1): 105–8. doi:10.1006/geno.1998.5295. PMID 9628828.

[pmid9355738-6] Tan F, Rehli M, Krause SW, Skidgel RA (Oct 1997). "Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains". The Biochemical Journal. 327 ( Pt 1) (Pt 1): 81–7. doi:10.1042/bj3270081. PMC 1218766 . PMID 9355738.

[entrez-7] 1 2 "Entrez Gene: CPD carboxypeptidase D".

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CPD (gene)

Contents

Function

Related Research Articles

References

Further reading

External links