Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene.
Spectrin beta chain, brain 1 is a protein that in humans is encoded by the SPTBN1 gene.
Ski-like protein is a protein that in humans is encoded by the SKIL gene.
Annexin A7 is a protein that in humans is encoded by the ANXA7 gene.
Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.
Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene.
Calcium-binding and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the CALCOCO1 gene.
Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.
Grancalcin is a protein that in humans is encoded by the GCA gene.
Copine-8 is a protein that in humans is encoded by the CPNE8 gene.
C-Myc-binding protein is a protein that in humans is encoded by the MYCBP gene.
Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.
Copine-1 is a protein that in humans is encoded by the CPNE1 gene.
Calcium-dependent secretion activator 2 is a protein that in humans is encoded by the CADPS2 gene.
Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.
Copine-6 is a protein that in humans is encoded by the CPNE6 gene.
Phospholipid scramblase 4, also known as Ca2+-dependent phospholipid scramblase 4, is a protein that is encoded in humans by the PLSCR4 gene.
In molecular biology, copines is a name for the group of human proteins that includes members such as CPNE1, CPNE4, CPNE6, and CPNE8. These are highly conserved, calcium-dependent membrane proteins found in a variety of eukaryotes. The domain structure of these 55 kDa proteins suggests that they may have a role in membrane trafficking in some prokaryotes as well as eukaryotes. Copines contains two C2 domains which play a role in signal transduction by binding to calcium, phospholipids, or polyphosphates. Both domains are located at the N-terminal portion of the protein which is not the case for most other double C2 domain proteins, and their role is most similar to that carried out by proteins that exhibit a single C2 domain. The core domain located at the C-terminus part of the copine is found to have a unique and conserved primary sequence. The function of the core domain is still uncertain, however, researchers believe it has a similar function to the "A domain" in integrins. This similarity in function involves serving as a binding site for target proteins, and is supported by evidence that the copine core domain exhibits secondary and tertiary structures comparable to the integrin A domain.
Coiled-coil domain containing 22 is a protein that in humans is encoded by the CCDC22 gene.
