CPNE4

CPNE4
Identifiers
Aliases	CPNE4 , COPN4, CPN4, copine 4
External IDs	OMIM: 604208; MGI: 1921270; HomoloGene: 26078; GeneCards: CPNE4; OMA:CPNE4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q22.1 Start 131,533,555 bp [1] End 132,285,410 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F1 Start 104,424,485 bp [2] End 104,911,743 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus myocardium of left ventricle endothelial cell primary visual cortex Brodmann area 23 palpebral conjunctiva dorsolateral prefrontal cortex Brodmann area 9 Brodmann area 46 right ventricle Top expressed in dentate gyrus of hippocampal formation granule cell lumbar spinal ganglion hippocampus proper trigeminal ganglion primary visual cortex habenula superior frontal gyrus olfactory bulb temporal lobe glossopharyngeal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding calcium-dependent phospholipid binding Cellular component extracellular exosome plasma membrane Biological process cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 131034 74020 Ensembl ENSG00000196353 ENSMUSG00000032564 UniProt Q96A23 Q4G168 Q8BLR2 RefSeq (mRNA) NM_001289112 NM_130808 NM_153429 NM_001388326 NM_001388327 NM_028719 NM_001357439 NM_001378996 RefSeq (protein) NP_001276041 NP_570720 NP_702907 NP_001276041.1 NP_570720.1 NP_702907.1 NP_082995 NP_001344368 NP_001365925 Location (UCSC) Chr 3: 131.53 – 132.29 Mb Chr 9: 104.42 – 104.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Copine-4 is a protein that in humans is encoded by the CPNE4 gene. ^{[5] [6] [7]}

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm.

This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000196353 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032564 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J (Feb 1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J Biol Chem. 273 (3): 1393–402. doi: 10.1074/jbc.273.3.1393 . PMID   9430674.
6. Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B (Apr 2003). "Cloning, molecular characterization, and expression analysis of Copine 8". Biochem Biophys Res Commun. 303 (3): 842–7. doi:10.1016/S0006-291X(03)00445-5. PMID   12670487.
7. "Entrez Gene: CPNE4 copine IV".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". J. Biol. Chem. 278 (12): 10048–54. doi: 10.1074/jbc.M212632200 . PMID   12522145.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.

External links

• Human CPNE4 genome location and CPNE4 gene details page in the UCSC Genome Browser .