CPNE8

CPNE8
Identifiers
Aliases	CPNE8 , copine 8
External IDs	MGI: 1914121; HomoloGene: 12049; GeneCards: CPNE8; OMA:CPNE8 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q12 Start 38,646,822 bp [1] End 38,907,430 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E3 Start 90,371,685 bp [2] End 90,563,635 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell Achilles tendon sperm monocyte right auricle of heart testicle right lung retinal pigment epithelium subcutaneous adipose tissue right lobe of liver Top expressed in lumbar spinal ganglion lateral septal nucleus epithelium of small intestine seminal vesicula lip Region I of hippocampus proper otolith organ utricle facial motor nucleus blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function calcium-dependent phospholipid binding Cellular component extracellular exosome plasma membrane Biological process biological process cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 144402 66871 Ensembl ENSG00000139117 ENSMUSG00000052560 UniProt Q86YQ8 Q9DC53 RefSeq (mRNA) NM_153634 NM_001033851 NM_025815 NM_001357979 RefSeq (protein) NP_705898 NP_001029023 NP_080091 NP_001344908 Location (UCSC) Chr 12: 38.65 – 38.91 Mb Chr 15: 90.37 – 90.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Copine-8 is a protein that in humans is encoded by the CPNE8 gene. ^{[5] [6]}

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000139117 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052560 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B (Apr 2003). "Cloning, molecular characterization, and expression analysis of Copine 8". Biochem Biophys Res Commun. 303 (3): 842–847. doi:10.1016/S0006-291X(03)00445-5. PMID   12670487.
6. "Entrez Gene: CPNE8 copine VIII".

Further reading

• Creutz CE, Tomsig JL, Snyder SL, et al. (1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J. Biol. Chem. 273 (3): 1393–1402. doi: 10.1074/jbc.273.3.1393 . PMID   9430674.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Tomsig JL, Creutz CE (2001). "Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein". Biochemistry. 39 (51): 16163–16175. doi:10.1021/bi0019949. PMID   11123945.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ramsey H, Zhang DE, Richkind K, et al. (2003). "Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation". Leukemia. 17 (8): 1665–1666. doi: 10.1038/sj.leu.2403048 . PMID   12886257.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415 –D418. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.

External links

• Human CPNE8 genome location and CPNE8 gene details page in the UCSC Genome Browser .