Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene.
Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.
Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.
RING finger protein 38 is a protein that in humans is encoded by the RNF38 gene.
LIM/homeobox protein Lhx6 is a protein that in humans is encoded by the LHX6 gene.
Allograft inflammatory factor 1-like is a protein that is encoded by the AIF1L gene in humans.
SH3-containing GRB2-like protein 3-interacting protein 1 is a protein that in humans is encoded by the SGIP1 gene.
Voltage-dependent calcium channel gamma-3 subunit is a protein that in humans is encoded by the CACNG3 gene.
THAP domain-containing protein 6 is a protein that in humans is encoded by the THAP6 gene.
NADH dehydrogenase [ubiquinone] 1 subunit C2 is an enzyme that in humans is encoded by the NDUFC2 gene.
Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.
Alpha- and Gamma-Adaptin Binding Protein, also known as AAGAB, is a human gene.
Copine-1 is a protein that in humans is encoded by the CPNE1 gene.
Calcium-dependent secretion activator 2 is a protein that in humans is encoded by the CADPS2 gene.
SCAN domain-containing protein 3 is a protein that in humans is encoded by the SCAND3 gene.
Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.
Serine/threonine-protein kinase 40 is an enzyme that in humans is encoded by the STK40 gene.
Copine-6 is a protein that in humans is encoded by the CPNE6 gene.
Copine-4 is a protein that in humans is encoded by the CPNE4 gene.
In molecular biology, copines is a name for the group of human proteins that includes members such as CPNE1, CPNE4, CPNE6, and CPNE8. These are highly conserved, calcium-dependent membrane proteins found in a variety of eukaryotes. The domain structure of these 55 kDa proteins suggests that they may have a role in membrane trafficking in some prokaryotes as well as eukaryotes. Copines contains two C2 domains which play a role in signal transduction by binding to calcium, phospholipids, or polyphosphates. Both domains are located at the N-terminal portion of the protein which is not the case for most other double C2 domain proteins, and their role is most similar to that carried out by proteins that exhibit a single C2 domain. The core domain located at the C-terminus part of the copine is found to have a unique and conserved primary sequence. The function of the core domain is still uncertain, however, researchers believe it has a similar function to the "A domain" in integrins. This similarity in function involves serving as a binding site for target proteins, and is supported by evidence that the copine core domain exhibits secondary and tertiary structures comparable to the integrin A domain.
