CPXM1

CPXM1
Identifiers
Aliases	CPXM1 , CPX1, CPXM, carboxypeptidase X (M14 family), member 1, carboxypeptidase X, M14 family member 1
External IDs	OMIM: 609555; MGI: 1934569; HomoloGene: 10485; GeneCards: CPXM1; OMA:CPXM1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 2,794,074 bp [1] End 2,800,627 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 F1 Start 130,232,695 bp [2] End 130,239,494 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua gallbladder cartilage tissue canal of the cervix ectocervix smooth muscle tissue body of uterus parietal pleura left uterine tube ganglionic eminence Top expressed in calvaria epithelium of lens external carotid artery mesenteric lymph nodes efferent ductule dermis body of femur sciatic nerve Gonadal ridge vestibular sensory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function carboxypeptidase activity zinc ion binding peptidase activity hydrolase activity metallopeptidase activity metal ion binding metallocarboxypeptidase activity serine-type carboxypeptidase activity Cellular component extracellular region extracellular space Biological process protein processing peptide metabolic process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56265 56264 Ensembl ENSG00000088882 ENSMUSG00000027408 UniProt Q96SM3 Q9Z100 RefSeq (mRNA) NM_019609 NM_001184699 NM_019696 RefSeq (protein) NP_001171628 NP_062555 NP_062670 Location (UCSC) Chr 20: 2.79 – 2.8 Mb Chr 2: 130.23 – 130.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable carboxypeptidase X1 is an enzyme that in humans is encoded by the CPXM1 gene. ^{[5] [6]}

The protein encoded by this gene is a member of the M14 family of zinc carboxypeptidases; however, the protein has no detectable carboxypeptidase activity. The encoded protein is thought to be an extracellular and/or membrane protein, and may be involved in cell-cell interactions. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000088882 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027408 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S (Dec 2003). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
6. "Entrez Gene: CPXM1 carboxypeptidase X (M14 family), member 1".

External links

• Human CPXM1 genome location and CPXM1 gene details page in the UCSC Genome Browser .

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi: 10.1186/gb-2004-5-2-r8 . PMC   395752 . PMID   14759258.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Lei Y, Xin X, Morgan D, et al. (1999). "Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2". DNA Cell Biol. 18 (2): 175–85. doi:10.1089/104454999315565. PMID   10073577.