CREG1

CREG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XHN
Identifiers
Aliases	CREG1 , CREG, cellular repressor of E1A stimulated genes 1
External IDs	OMIM: 618055 MGI: 1344382 HomoloGene: 31199 GeneCards: CREG1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q24.2 Start 167,529,117 bp [1] End 167,553,805 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H2.3 Start 165,591,315 bp [2] End 165,602,877 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle vulva gallbladder parotid gland lower lobe of lung cancellous bone human penis right coronary artery lactiferous duct superficial temporal artery Top expressed in blood left lobe of liver Epithelium of stomach saccule otic placode lacrimal gland right lung lobe islet of Langerhans medial dorsal nucleus parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding transcription corepressor activity Cellular component extracellular exosome transcription regulator complex extracellular region extracellular space azurophil granule lumen Biological process regulation of transcription by RNA polymerase II multicellular organism development regulation of growth cell population proliferation regulation of transcription, DNA-templated negative regulation of nucleic acid-templated transcription neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8804 433375 Ensembl ENSG00000143162 ENSMUSG00000040713 UniProt O75629 O88668 RefSeq (mRNA) NM_003851 NM_011804 RefSeq (protein) NP_003842 NP_035934 Location (UCSC) Chr 1: 167.53 – 167.55 Mb Chr 1: 165.59 – 165.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein CREG1 (Cellular Repressor of E1A-stimulated Genes 1) is a protein that in humans is encoded by the CREG1 gene. ^{[5] [6]}

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000143162 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040713 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Veal E, Eisenstein M, Tseng ZH, Gill G (Sep 1998). "A Cellular Repressor of E1A-Stimulated Genes That Inhibits Activation by E2F". Mol Cell Biol. 18 (9): 5032–41. doi:10.1128/mcb.18.9.5032. PMC   109088 . PMID   9710587.
6. "Entrez Gene: CREG1 cellular repressor of E1A-stimulated genes 1".

External links

• Human CREG1 genome location and CREG1 gene details page in the UCSC Genome Browser .

Further reading

• Veal E, Groisman R, Eisenstein M, Gill G (2000). "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells". Oncogene. 19 (17): 2120–8. doi: 10.1038/sj.onc.1203529 . PMID   10815803.
• Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi: 10.1291/hypres.25.647 . PMID   12358155.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Di Bacco A, Gill G (2003). "The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor". Oncogene. 22 (35): 5436–45. doi: 10.1038/sj.onc.1206670 . PMID   12934103.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Sacher M, Di Bacco A, Lunin VV, et al. (2006). "The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18326–31. doi: 10.1073/pnas.0505071102 . PMC   1317909 . PMID   16344469.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.