CRISPLD2

CRISPLD2
Identifiers
Aliases	CRISPLD2 , CRISP11, LCRISP2, cysteine rich secretory protein LCCL domain containing 2, LGL1
External IDs	OMIM: 612434; MGI: 1926142; HomoloGene: 41792; GeneCards: CRISPLD2; OMA:CRISPLD2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q24.1 Start 84,819,985 bp [1] End 84,920,768 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E1 Start 120,719,177 bp [2] End 120,779,532 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua tibia pericardium left uterine tube gastric mucosa mucosa of urinary bladder tendon of biceps brachii canal of the cervix gallbladder skin of hip Top expressed in iris Paneth cell sciatic nerve umbilical cord aortic valve skin of external ear cervix ascending aorta cumulus cell ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosaminoglycan binding heparin binding Cellular component extracellular exosome transport vesicle extracellular region secretory granule lumen ficolin-1-rich granule lumen extracellular space extracellular matrix Biological process extracellular matrix organization face morphogenesis lung development neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83716 78892 Ensembl ENSG00000103196 ENSMUSG00000031825 UniProt Q9H0B8 Q8BZQ2 RefSeq (mRNA) NM_031476 NM_030209 NM_001310635 RefSeq (protein) NP_113664 NP_001297564 NP_084485 Location (UCSC) Chr 16: 84.82 – 84.92 Mb Chr 8: 120.72 – 120.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cysteine-rich secretory protein LCCL domain-containing 2 is a cysteine-rich secretory protein that in humans is encoded by the CRISPLD2 gene. ^{[5] [6]}

It has been predicted or experimentally observed to interact with C1orf173. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000103196 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031825 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
6. "Entrez Gene: CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2".
7. Liu F, Feng Y, Li Z, Pan C, Su Y, Yang R, Song L, Duan H, Deng N (2014). "Clinic-genomic association mining for colorectal cancer using publicly available datasets". Biomed Res Int. 2014 170289. doi: 10.1155/2014/170289 . PMC   4060771 . PMID   24987669.

External links

• Human CRISPLD2 genome location and CRISPLD2 gene details page in the UCSC Genome Browser .

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Chiquet BT, Lidral AC, Stal S, et al. (2008). "CRISPLD2: a novel NSCLP candidate gene". Hum. Mol. Genet. 16 (18): 2241–8. doi:10.1093/hmg/ddm176. PMC   3755375 . PMID   17616516.